Human/Mouse ROR gamma /RORC/NR1F3 Antibody Summary
Accession # P51449-2
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human and Mouse ROR gamma /NR1F3 by Western Blot. Western blot shows lysates of Jurkat human acute T cell leukemia cell line, EL-4 mouse lymphoblast cell line, and mouse thymus tissue. PVDF Membrane was probed with 0.5 µg/mL of Mouse Anti-Human/Mouse ROR gamma/NR1F3 Monoclonal Antibody (Catalog # MAB6109) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for ROR gamma/NR1F3 at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ROR gamma/RORC/NR1F3
ROR gamma (Nuclear receptor ROR-gamma), also called RORC and NR1F3, is a member of the NR1 nuclear hormone receptor family. ROR gamma is a DNA binding transcription factor. ROR gamma is 518 amino acids (aa) in length. Deletion in mice implicates ROR gamma as being essential for lymphoid organogenesis and controlling apoptosis during thymopoiesis. Two splice forms differing in the first 24 aa have been found for this gene; isoform 2 deletes aa 1‑21 resulting in an alteration of aa 22‑24. Over aa 1‑100 human RORC shares 96% identity with mouse ROR gamma.
Citations for Human/Mouse ROR gamma /RORC/NR1F3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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The YAP/HIF-1&alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation
Authors: J Zhou, N Zhang, W Zhang, C Lu, F Xu
Cell & bioscience, 2021;11(1):84.
Sample Types: Cell Lysates
Applications: Western Blot
Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages
Authors: J Xu, J Wang, X Wang, R Tan, X Qi, Z Liu, H Qu, T Pan, Q Zhan, Y Zuo, W Yang, J Liu
Cell Death Dis, 2020;11(10):934.
Sample Types: Tissue Homogenates
TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function.
Authors: Nyirenda MH, Sanvito L, Darlington PJ
J. Immunol., 2011;187(5):2278-90.
Sample Types: Whole Cells
Applications: Flow Cytometry
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