Human/Mouse TSG-6 Antibody

Catalog # Availability Size / Price Qty
MAB2104
MAB2104-SP
Product Details
Citations (5)
FAQs
Supplemental Products
Reviews (8)

Human/Mouse TSG-6 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects human and mouse TSG-6 in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG2B Clone # 259820
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TSG-6
Trp18-Leu277
Accession # P98066
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human TSG‑6 (Catalog # 2104-TS)
Recombinant Mouse TSG‑6 (Catalog # 2326-TS)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TSG-6

TSG-6 is a secreted hyaluronan-binding protein composed of a link domain and Cub domain. It is induced in many cell types by inflammatory mediators. Via its link domain, TSG-6 is a potent inhibitor of polymorphonuclear leukocyte migration. TSG-6 forms a stable complex with the serine protease inhibitor Inter-alpha -Inhibitor (I alpha I) and potentiates the anti-plasmin activity of I alpha I.

Long Name
Tumor Necrosis Factor-stimulated Gene Sequence 6
Entrez Gene IDs
7130 (Human); 21930 (Mouse)
Alternate Names
Hyaluronate-binding protein; TNF alpha-induced protein 6; TNFAIP6; TNF-stimulated gene 6 protein; TSG6; TSG-6; TSG-6tumor necrosis factor alpha-inducible protein 6; TSG6tumor necrosis factor-inducible gene 6 protein; Tumor necrosis factor alpha-induced protein 6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-stimulated gene-6 protein

Product Datasheets

Citations for Human/Mouse TSG-6 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Prostaglandin E2 Indicates Therapeutic Efficacy Of Mesenchymal Stem Cells In Experimental Traumatic Brain Injury
    Authors: DJ Kota, KS Prabhakara, N Toledano-F, D Bhattarai, Q Chen, B DiCarlo, P Smith, F Triolo, PL Wenzel, CS Cox, SD Olson
    Stem Cells, 2017;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. TNF?-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury
    Proc. Natl. Acad. Sci. U.S.A., 2016;113(50):E8151-E8158.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Endogenous mesenchymal stromal cells in bone marrow are required to preserve muscle function in mdx mice.
    Authors: Fujita R, Tamai K, Aikawa E, Nimura K, Ishino S, Kikuchi Y, Kaneda Y
    Stem Cells, 2015;33(3):962-75.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  4. Constitutive expression of inter-alpha-inhibitor (IalphaI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex.
    Authors: Zhang S, He H, Day AJ, Tseng SC
    J. Biol. Chem., 2012;287(15):12433-44.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  5. Biochemical characterization and function of complexes formed by hyaluronan and the heavy chains of inter-alpha-inhibitor (HC*HA) purified from extracts of human amniotic membrane.
    Authors: He H, Li W, Tseng DY, Zhang S, Chen SY, Day AJ, Tseng SC
    J. Biol. Chem., 2009;284(30):20136-46.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot

FAQs

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Reviews for Human/Mouse TSG-6 Antibody

Average Rating: 4.1 (Based on 8 Reviews)

5 Star
25%
4 Star
62.5%
3 Star
12.5%
2 Star
0%
1 Star
0%

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Human/Mouse TSG-6 Antibody
By Anonymous on 09/10/2021
Application: WB Sample Tested: extracellular vesicles Species: Human

Human/Mouse TSG-6 Antibody
By Anonymous on 09/01/2021
Application: WB Sample Tested: Plasma Species: Mouse

Human/Mouse TSG-6 Antibody
By Anonymous on 08/06/2021
Application: WB Sample Tested: Brain (cerebral cortex) Species: Mouse

this antibody was detected in the mouse cortex at different timepoint. It works very good with very clear band.


Human/Mouse TSG-6 Antibody
By Anonymous on 03/11/2019
Application: Microarrays Sample Tested: EDTA Plasma Species: Human

Human/Mouse TSG-6 Antibody
By Anonymous on 02/21/2019
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Human/Mouse TSG-6 Antibody
By Anonymous on 01/19/2019
Application: WB Sample Tested: HUVEC human umbilical vein endothelial cells Species: Human

Western Blot with diff concentration


Human/Mouse TSG-6 Antibody
By Anonymous on 12/08/2018
Application: IHC Sample Tested: HUVEC human umbilical vein endothelial cells Species: Human

Human/Mouse TSG-6 Antibody
By Anonymous on 11/11/2018
Application: ELISA Sample Tested: Serum and Plasma Species: Human