Human SLITRK5 Antibody

  
  • Species Reactivity
    Human
  • Specificity
    Detects human SLITRK5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human SLITRK1, 2, 3, or 4 is observed.
  • Source
    Monoclonal Mouse IgG2B Clone # 310516
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human SLITRK5
    Glu39-Val665
    Accession # O94991
  • Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    1 µg/mL
    Recombinant Human SLITRK5 (Catalog # 2587-SK)
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
  • Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SLITRK5

SLITRK5 (Slit and Trk-like family member 5; also named LRR-containing protein 11) is a member of the SLITRK family of proteins (1, 2). This family currently includes six members, all of which contain a slit-like extracellular region and (save for SLITRK1) a Trk-like cytoplasmic region (3). Human SLITRK5 is a type I transmembrane (TM) protein that is 958 amino acids (aa) in length. It contains a putative 40 aa signal sequence, a 624 aa extracellular domain (ECD), a 21 aa TM segment, and a 273 aa cytoplasmic region. The ECD is characterized by the presence of two leucine-rich domains (LRD) that resemble those found in slit. Each LRD (aa 80‑285 plus aa 384‑579) contains seven and eight leucine-rich repeats (LRRs), respectively. Based on other LRRs, it is likely that the LRRs mediate protein-protein-interaction (4). The cytoplasmic region contains two conserved, potential phosphorylation sites at Tyr833 and Tyr917, plus a TrkA-like tyrosine phosphorylation site (YLxxL) at Tyr945. SLITRK5 is expressed on embryonic neurons of the hippocampus (pyramidal layer) and thalamus (3). Based on SLITRK2 studies, SLITRK5 will block neurite extension (3). SLITRK5 is markedly upregulated in many neurological tumors. Human SLITRK5 shares 97% and 98% aa identity with mouse and canine SLITRK5, respectively.

  • References:
    1. Aruga, J. et al. (2003) Gene 315:87.
    2. Nagase, T. et al. (2001) DNA Res. 8:179.
    3. Aruga, J. and K. Mikoshiba (2003) Mol. Cell. Neurosci. 24:117.
    4. Enkhbayar, P. et al. (2003) Proteins 54:394.
  • Long Name:
    SLIT and NTRK-like Family, Member 5
  • Entrez Gene IDs:
    26050 (Human); 75409 (Mouse); 306152 (Rat)
  • Alternate Names:
    bA364G4.2; FLJ58374; KIAA0918; leucine-rich repeat-containing protein 11; LRRC11; SLIT and NTRK-like family, member 5; SLIT and NTRK-like protein 5; SLITRK5
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