Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
SLITRK5 (Slit and Trk-like family member 5; also named LRR-containing protein 11) is a member of the SLITRK family of proteins (1, 2). This family currently includes six members, all of which contain a slit-like extracellular region and (save for SLITRK1) a Trk-like cytoplasmic region (3). Human SLITRK5 is a type I transmembrane (TM) protein that is 958 amino acids (aa) in length. It contains a putative 40 aa signal sequence, a 624 aa extracellular domain (ECD), a 21 aa TM segment, and a 273 aa cytoplasmic region. The ECD is characterized by the presence of two leucine-rich domains (LRD) that resemble those found in slit. Each LRD (aa 80‑285 plus aa 384‑579) contains seven and eight leucine-rich repeats (LRRs), respectively. Based on other LRRs, it is likely that the LRRs mediate protein-protein-interaction (4). The cytoplasmic region contains two conserved, potential phosphorylation sites at Tyr833 and Tyr917, plus a TrkA-like tyrosine phosphorylation site (YLxxL) at Tyr945. SLITRK5 is expressed on embryonic neurons of the hippocampus (pyramidal layer) and thalamus (3). Based on SLITRK2 studies, SLITRK5 will block neurite extension (3). SLITRK5 is markedly upregulated in many neurological tumors. Human SLITRK5 shares 97% and 98% aa identity with mouse and canine SLITRK5, respectively.
Aruga, J. et al. (2003) Gene 315:87.
Nagase, T. et al. (2001) DNA Res. 8:179.
Aruga, J. and K. Mikoshiba (2003) Mol. Cell. Neurosci. 24:117.
Enkhbayar, P. et al. (2003) Proteins 54:394.
SLIT and NTRK-like Family, Member 5
Entrez Gene IDs:
26050 (Human); 75409 (Mouse); 306152 (Rat)
bA364G4.2; FLJ58374; KIAA0918; leucine-rich repeat-containing protein 11; LRRC11; SLIT and NTRK-like family, member 5; SLIT and NTRK-like protein 5; SLITRK5
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