Human TAFA2/FAM19A2 Antibody
Human TAFA2/FAM19A2 Antibody Summary
Accession # AAH28403
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
TAFA2, also called FAM19A2, is a secreted, 11 kDa member of the FAM19/TAFA family of chemokine-like proteins (1). It is synthesized as a 131 amino acid (aa) precursor that contains a 30 aa signal sequence and a 101 aa mature chain. Like other members of the FAM19/TAFA family, with the exception of TAFA5, mature TAFA1 contains 10 regularly spaced cysteine residues that follow the pattern CX7CCX13CXCX14CX11CX4CX5CX10C, where C represents a conserved cysteine residue and X represents any noncysteine amino acid (1). Human TAFA2 shares 97% aa sequence identity with mouse TAFA2 (1). TAFA2 expression can be detected in the central nervous system (CNS), colon, heart, lung, spleen, kidney, and thymus, but its expression in the CNS is 50- to 1000-fold higher than in other tissues (1). Within the CNS, TAFA2 expression is highest in the occipital and frontal cortex (3- to 10-fold more abundantly expressed than in other cortical regions) and medulla (1). Hypotheses for the biological functions of TAFA family members include modulating immune responses in the CNS by functioning as brain-specific chemokines, acting with other chemokines to optimize the recruitment and activity of immune cells in the CNS (1). Alternately, TAFAs may represent a novel class of neurokines that act as regulators of immune nervous cells (1 - 2). Finally, TAFAs may control axonal sprouting following brain injury (1).
- Tang, Y.T. et al. (2004) Genomics 83:727.
- Benveniste, E. (1998) Cytokine Growth Factor Rev. 9:259.
Citation for Human TAFA2/FAM19A2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
TAFA2 induces skeletal (stromal) stem cell migration through activation of Rac1-p38 signaling
Authors: A Jafari, A Isa, L Chen, N Ditzel, W Zaher, L Harkness, HE Johnsen, BM Abdallah, C Clausen, M Kassem
Stem Cells, 2018-12-17;0(0):.
Sample Types: Cell Lysates
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