Human TR beta 1/NR1A2 Antibody

R&D Systems | Catalog # PP-H3825A-00

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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Direct ELISA, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # H3825A
View all TR beta 1/NR1A2 Primary Antibodies »

Product Specifications

Immunogen

Recombinant human TR beta 1/NR1A2
aa 2-100

Specificity

This antibody specifically recognizes human TR beta 1, and does not cross-react with human TR beta 2 or human TR alpha. Not yet tested in other species.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human TR beta 1/NR1A2 Antibody

Application
Recommended Usage

Direct ELISA

This antibody can be used at 0.1 μg/mL with the appropriate secondary reagents to detect human TR beta 1.

Immunoprecipitation

Optimal dilutions should be determined by each laboratory.

Western Blot

This antibody can be used at 1 μg/mL under reducing conditions with the appropriate secondary reagents to detect human TR beta 1.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

A liquid formulation in physiologic saline with 0.1% NaN3.

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: TR beta 1/NR1A2

Thyroid Hormone Receptor beta (TR beta, THRB; NR1A2) is a member of the Nuclear Hormone Receptor superfamily. The ligands for TR beta are the thyroid hormones, which exist in two forms: T4 (3,5,3',5'-tetraiodo-L-thyronine) and T3 (3,5,3'-tri-iodo-L-thyronine). TR beta plays critical roles in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the Retinoid X Receptors (RXRs), which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of TR.

Long Name

Thyroid Hormone Receptor beta 1

Alternate Names

NR1A2, THRB, v-ErbA2

Entrez Gene IDs

7068 (Human)

Gene Symbol

THRB

Additional TR beta 1/NR1A2 Products

Product Documents for Human TR beta 1/NR1A2 Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human TR beta 1/NR1A2 Antibody

For research use only

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FAQs

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