Human TR beta 1/NR1A2 Antibody

  
  • Species Reactivity
    Human
  • Specificity
    This antibody specifically recognizes human TR beta 1, and does not cross-react with human TR beta 2 or human TR alpha. Not yet tested in other species.
  • Source
    Monoclonal Mouse IgG2A Clone # H3825A
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Recombinant human TR beta 1/NR1A2
    aa 2-100
  • Formulation
    A liquid formulation in physiologic saline with 0.1% NaN3.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    This antibody can be used at 1 μg/mL under reducing conditions with the appropriate secondary reagents to detect human TR beta 1.
  • Immunoprecipitation
    Optimal dilutions should be determined by each laboratory.
  • Direct ELISA
    This antibody can be used at 0.1 μg/mL with the appropriate secondary reagents to detect human TR beta 1.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
  • Shipping
    The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Background: TR beta 1/NR1A2
Thyroid Hormone Receptor beta (TR beta, THRB; NR1A2) is a member of the Nuclear Hormone Receptor superfamily. The ligands for TR beta are the thyroid hormones, which exist in two forms: T4 (3,5,3',5'-tetraiodo-L-thyronine) and T3 (3,5,3'-tri-iodo-L-thyronine). TR beta plays critical roles in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the Retinoid X Receptors (RXRs), which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of TR.
  • Long Name:
    Thyroid Hormone Receptor beta 1
  • Entrez Gene IDs:
    7068 (Human)
  • Alternate Names:
    avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2; c-erbA-2; c-erbA-beta; ERBA2MGC126109; ERBA-BETA; GRTH; MGC126110; NR1A2; NR1A2thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog 2); Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; THR1pituitary resistance to thyroid hormone; THRB; THRB1; THRB2; thyroid hormone receptor beta 1; thyroid hormone receptor beta; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a)oncogene homolog 2, avian); TR beta 1; v-ErbA2
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