Human TRIM38 Antibody

Catalog # Availability Size / Price Qty
MAB9104-SP
MAB9104-100
TRIM38  in Human Lymph Node.
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Human TRIM38 Antibody Summary

Species Reactivity
Human
Specificity
Detects human TRIM38 in direct ELISAs.
Source
Monoclonal Mouse IgG2B Clone # 933011
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E.coli-derived recombinant human TRIM38
Leu190-Ile414
Accession # O00635
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
5-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Immunohistochemistry TRIM38  in Human Lymph Node. View Larger

TRIM38 in Human Lymph Node. TRIM38 was detected in immersion fixed paraffin-embedded sections of human lymph node in small intestine using Mouse Anti-Human TRIM38 Monoclonal Antibody (Catalog # MAB9104) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in lymphocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TRIM38

Human Tripartite Motif 38 (TRIM38, RNF15) is a 465 aminoacids E3 ubiquitin ligase that plays a key role in tuning TLR-mediated immune responses by selectively targeting molecules in the TLR signaling for proteasomal degradation. The TRIM family of E3 ligases has more than 70 members in humans. Many members of this protein family are important immune regulators, mediating innate immune cell signal transduction and subsequent cytokine induction immune regulation. Trim38 deficiency, for example, greatly increases TLR3- and TLR4-mediated induction of type I Interferons and proinflammatory cytokines, such as TNF-alpha, IL-1 beta, and IL-6, in immune cells and in vivo.

Long Name
Tripartite Motif-containing 38
Entrez Gene IDs
10475 (Human); 214158 (Mouse); 680019 (Rat)
Alternate Names
MGC8946; RING finger protein 15RORETRo/SSA ribonucleoprotein homolog; RNF15; RoRet; TRIM38; tripartite motif containing 38; tripartite motif-containing 38; tripartite motif-containing protein 38; Zinc finger protein RoRet; zinc-finger protein RoRet

Product Datasheets

FAQs

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Cell and Tissue Staining Kits

Immunohistochemistry Reagents

Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Mouse IgG2B Antibody

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