Mouse CD4 Antibody
Mouse CD4 Antibody Summary
Lys27-Thr394
Accession # P06332
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD4
CD4 (Cluster of Differentiation #4; also L3T4) is a 55 kDa member of the Ig Superfamily of molecules. It is expressed on a variety of hematopoietic cell types, including immature thymocytes, a number of variable phenotype single positive T cells (i.e.- CD25+; CD39+; Th1, 2 and 17 type cells), stimulated CD8+ T cells, pluripotent bone marrow stem cells, and NKT cells. Although CD4 is a standard phenotype marker, functionally, the molecule is known to bind to APC MHC class II, and to associate with adjacent CD3 molecules to link p56lck with the lymphocyte TCR:CD3 complex. Mature mouse CD4 is a 431 amino acid (aa) type I transmembrane glycoprotein. It contains a 368 aa extracellular region (aa 27-394) plus a 40 aa cytoplasmic domain (aa 418-457). The extracellular region contains one V-type (aa 27-128) and three C2-type Ig-like domains (aa 129-374). There is one alternative start site at Met241 that is utilized in brain. Over aa 27-394, mouse CD4 shares 53% and 72% aa identity with human and rat CD4, respectively.
Product Datasheets
Citations for Mouse CD4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Determinants in the beta and delta subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.
Authors: Rudell J, Borges L, Rudell J, Beck K, Ferns M
J Biol Chem, 2014;289(1):203-14.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice.
Authors: Cann JA, Register TC, Adams MR, St Clair RW, Espeland MA, Williams JK
Atherosclerosis, 2008;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr
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