Mouse MMP-9 Antibody

Catalog # Availability Size / Price Qty
AF909
AF909-SP

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Detection of Mouse MMP‑9 by Western Blot.
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Product Details
Citations (75)
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Reviews (2)

Mouse MMP-9 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse MMP-9 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) MMP-9 is observed and less than 2% cross-reactivity with rhMMP-1, -2, -3, -7, -8, -10, -12, and -13 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MMP‑9
Ala20-Pro730
Accession # P41245
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
.25 µg/mL
See below
Simple Western
5 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
Perfusion fixed frozen sections of rat brain (cingulate cortex), and Immersion fixed paraffin-embedded sections of mouse thymus
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Mouse MMP‑9 (Catalog # 909-MM), see our available Western blot detection antibodies
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse MMP-9 antibody by Western Blot. View Larger

Detection of Mouse MMP‑9 by Western Blot. Western blot shows lysates of mouse spleen tissue and mouse lung tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse MMP-9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF909) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF019). A specific band was detected for MMP-9 at approximately 100 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry MMP-9 antibody in Mouse Splenocytes by Immunocytochemistry (ICC). View Larger

MMP‑9 in Mouse Splenocytes. MMP-9 was detected in immersion fixed mouse splenocytes using Goat Anti-Mouse MMP-9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF909) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Simple Western Detection of Mouse MMP-9 antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Mouse MMP‑9 by Simple WesternTM. Simple Western lane view shows lysates of mouse lung tissue and mouse spleen tissue, loaded at 0.2 mg/mL. A specific band was detected for MMP-9 at approximately 155 kDa (as indicated) using 5 µg/mL of Goat Anti-Mouse MMP-9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF909) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Immunohistochemistry MMP‑9 antibody in Rat Brain by Immunohistochemistry (IHC-Fr). View Larger

MMP‑9 in Rat Brain. MMP-9 was detected in perfusion fixed frozen sections of rat brain (cingulate cortex) using 1.7 µg/mL Goat Anti-Mouse MMP-9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF909) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Immunohistochemistry Detection of Mouse MMP-9 by Immunohistochemistry View Larger

Detection of Mouse MMP-9 by Immunohistochemistry Remodeled ECM enhances the invasive behaviors of ovarian cancer cells. (a) H&E stain of the tumor lesions from WT and ApoE−/− mice at two weeks post ID8 engraftment (left). Graph represents the mean size of the lesions calculated from ten random fields (right). (b) Masson’s Trichrome stain of tumor lesions (left). The mean percentage of positive regions in ten random fields was calculated (right). (c) The cytokines/chemokines profile in the supernatants of ascites from WT and ApoE−/− mice. Four groups of mouse cytokine dot-blot arrays are shown. Dot-blots with significant changes are shown in boxed areas (red). (d) The top four pathways enriched among the molecules with significant changes using KEGG pathway analysis. (e) MMP-10 and MMP-9 protein expression in tumor lesions, determined by blinded IHC analysis (left). Box plot of the IHC score of MMP-10 and MMP-9 (right). Box represents the 25th–75th percentile while whiskers indicate the 5th–95th percentile. The black box represents tumor lesions from WT mice and the grey box represents tumor lesions from ApoE−/− mice. Each experiment included data from 5 mice. Bar represents 50 μm. *P < 0.05; **P < 0.005 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29458390), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse MMP-9 by Immunohistochemistry View Larger

Detection of Mouse MMP-9 by Immunohistochemistry Remodeled ECM promotes malignancy of ovarian cancer via FAK-ERK-MMP activation. (a) Specimens from Fig. 5D were immunoassayed for p-FAKY397 (red), and nuclei were stained with Hoechst (blue). (b) IHC of active ERK (p-p44/42 MAPKThr202/Tyr204) in tumor lesions from WT and ApoE−/− mice with PBS or BAPN treatment two weeks after ID8 engraftment. (c) PBS or PD-325901 was administrated to ApoE−/− mice once ID8-Luciferase cells were intraperitoneally injected and treatment continued for one month. The representative images (top) and quantification data (bottom) of MMP-9 protein expression in tumor lesions two months after ID8 engraftment. (d) In vivo luciferase expression was determined two weeks or two months post treatment. Luminescence (right panel) is represented as the radiance (p/s/cm2/sr). Each experiment included data from 4 mice. Bar represents 50 μm. *P < 0.05; **P < 0.005 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29458390), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse MMP-9 by Western Blot View Larger

Detection of Mouse MMP-9 by Western Blot Fibrotic deposit and cardiac dysfunction correlate with decreasing CVPC presence in mdx heart. (A) Representative images of histological analysis stained using Masson trichrome technique showing myocytes (in red) and collagenous fibrotic tissue (in blue) in the left ventricle of WT and mdx hearts at 9, 24, and 52 wo. Line represents 100 µm. (B) The ratio of red and blue stained tissue was evaluated in WT hearts (open bars and black dots, n = 4–11 slices/3 animals per group) and mdx hearts (black bars and grey dots, n = 3–16 slices/3 animals per group) at the age of 24 wo and further at 52 wo. Statistical significance was calculated by Kruskal–Wallis test and Dunn‘s multiple comparison post-hoc test (*** p < 0.001, **** p < 0.0001). (C) Western blot analysis of collagen proteins and inflammatory proteins in the cardiac tissues. Left panel shows representative images of collagen 1A1 (Coll 1A1), collagen 3 (Coll 3), cyclooxygenase 2 (COX-2), and matrix metalloproteinase 9 (MMP-9) compared to the GAPDH control. The right panels show the normalized densitometry of each protein normalized by GAPDH content of WT (open bars, n = 2 animals) and mdx (black bars, n = 2 animals). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/34068508), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse MMP-9 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse MMP-9 by Immunocytochemistry/Immunofluorescence MMP2, MMP9, and RANKL expression in AAAs.A. Immunohistochemical staining for indicated proteins of serial sections of aortas one week after CaCl2 treatment. Elastic van Gieson staining is also shown. SM alpha -actin and F4/80 were stained to locate SMCs and macrophages, respectively. Shown are representative images of 4 or more samples in each group. Scale bars, 50 µm. B. Relative positive staining area of MMP2, MMP9, and RANKL in sections from control diet and EPA diet groups. n = 4–5. *P<0.05. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0096286), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse MMP-9 by Immunohistochemistry View Larger

Detection of Mouse MMP-9 by Immunohistochemistry BAPN treatment delays ovarian cancer progression by reducing adhesions. (a) Experimental design: PBS or BAPN was intraperitoneally administrated to 20-weeks-old female ApoE−/− mice each day and continued for four weeks. A cohort of mice was sacrificed for further experiments. For the remaining mice, the drug treatment was stopped for two weeks before the establishment of ID8 allografts. (b) Hydroxyproline was measured in the plasma and diaphragm. (c) Masson’s Trichrome stain after BAPN treatment (left). The positive-staining percentage of 10 random fields was calculated (right). Bar represents 50 μm. (d) Cells adhesive to the omentum were analyzed four hours after ID8 intraperitoneal injection by fluorescence microscopy (left). The adhesive cells were determined from the total fluorescent intensity after digestion (right). Bar represents 200 μm. (e) In vivo luciferase measured at two weeks (top) and two months (bottom) post establishment in ApoE−/− mice with PBS or BAPN pre-treatment. Quantification of luminescence is represented as the radiance. (f) MMP-9 expression measured by IHC in tumor lesions of ApoE−/− mice with PBS or BAPN treatment. Each experiment includes data from 4 mice. Bar represents 50 μm. *P < 0.05; **P < 0.005 Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29458390), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry View Larger

Detection of MMP‑9 in Mouse Thymus. MMP‑9 was detected in immersion fixed paraffin-embedded sections of mouse thymus using Goat Anti-Mouse MMP‑9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF909) at 1.7 µg/ml for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm and macrophages. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MMP-9

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-9 (gelatinase B) can degrade a broad range of substrates including gelatin, collagen types IV and V, elastin, and proteoglycan core protein. It is believed to act synergistically with interstitial collagenase (MMP-1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP-9 is produced by keratinocytes, monocytes, macrophages, and PMN leukocytes. MMP-9 is present in most cases of inflammatory responses. Structurally, MMP-9 may be divided into five distinct domains: a pro-domain which is cleaved upon activation, a gelatin-binding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a proline-rich linker region, and a carboxyl terminal hemopexin-like domain. Compared to the human MMP-9
(Catalog # 911-MP), the mouse enzyme contains extra sequences in the linker region and in the hemopexin-like domain, respectively.

Long Name
Matrix Metalloproteinase 9
Entrez Gene IDs
4318 (Human); 17395 (Mouse); 81687 (Rat); 102117693 (Cynomolgus Monkey)
Alternate Names
92 kDa gelatinase; 92 kDa type IV collagenase; CLG4B; EC 3.4.24; EC 3.4.24.35; Gelatinase B; GELB; macrophage gelatinase; MANDP2; matrix metallopeptidase 9; matrix metalloproteinase 9; matrix metalloproteinase-9; MMP9; MMP-9; type V collagenase

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Citations for Mouse MMP-9 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
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  1. Ulmus macrocarpa Hance trunk bark extracts inhibit RANKL-induced osteoclast differentiation and prevent ovariectomy-induced osteoporosis in mice
    Authors: Jeong, C;Lee, CH;Lee, Y;Seo, J;Wang, W;Park, KH;Oh, E;Cho, Y;Park, C;Son, YJ;Yoon Park, JH;Kang, H;Lee, KW;
    Journal of ethnopharmacology
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles
    Authors: Graca, FA;Stephan, A;Minden-Birkenmaier, BA;Shirinifard, A;Wang, YD;Demontis, F;Labelle, M;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
    Authors: M Crompton, JK Ferguson, R Ramnath, KL Onions, AS Ogier, M Gamez, CJ Down, LJ Skinner, KH Wong, LK Dixon, J Sutak, SJ Harper, P Pontrelli, L Gesualdo, HL Heerspink, RD Toto, GI Welsh, RR Foster, SC Satchell, MJ Butler
    JCI Insight, 2023-03-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  4. Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin-Deficient Mice via Upregulation of Angiotensin (1-7)
    Authors: K Karasaki, H Kokubo, B Bumdelger, N Kaji, C Sakai, M Ishida, M Yoshizumi
    Journal of the American Heart Association, 2023-01-31;12(3):e027589.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. NADPH oxidase 1 in chronic pancreatitis-activated pancreatic stellate cells facilitates the progression of pancreatic cancer
    Authors: A Chakrabort, B Halder, S Mondal, A Barrett, W Zhi, G Csanyi, ME Sabbatini
    American journal of cancer research, 2023-01-15;13(1):118-142.
    Species: Complex Species Category
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia
    Authors: H Shi, Z Yin, Y Koronyo, DT Fuchs, J Sheyn, MR Davis, JW Wilson, MA Margeta, KM Pitts, S Herron, S Ikezu, T Ikezu, SL Graham, VK Gupta, KL Black, M Mirzaei, O Butovsky, M Koronyo-Ha
    Acta neuropathologica communications, 2022-09-08;10(1):136.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  7. Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways
    Authors: T Yamasaki, T Horie, S Koyama, T Nakao, O Baba, M Kimura, N Sowa, K Sakamoto, K Yamazaki, S Obika, Y Kasahara, J Kotera, K Oka, R Fujita, T Sasaki, A Takemiya, K Hasegawa, K Minatoya, T Kimura, K Ono
    Scientific Reports, 2022-07-14;12(1):11984.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. TREM-1 is required for enhanced OpZ-induced superoxide generation following priming
    Authors: S Murthy, S Baruah, JL Bowen, K Keck, BA Wagner, GR Buettner, DB Sykes, J Klesney-Ta
    Journal of leukocyte biology, 2022-01-24;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  9. Temporal and Quantitative Analysis of Aortic Immunopathologies in Elastase-Induced Mouse Abdominal Aortic Aneurysms
    Authors: K Tian, C Xia, H Liu, B Xu, P Wei, W Fu, M Lu, Y Li, Y Li, D Cheng, E Liu, S Zhao
    Journal of Immunology Research, 2021-11-16;2021(0):6297332.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. Diving beetle-like miniaturized plungers with reversible, rapid biofluid capturing for machine learning-based care of skin disease
    Authors: S Baik, J Lee, EJ Jeon, BY Park, DW Kim, JH Song, HJ Lee, SY Han, SW Cho, C Pang
    Science Advances, 2021-06-16;7(25):.
    Species: Mouse
    Sample Types: Whole Tissues
    Applications: IHC
  11. Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation
    Authors: T Hasegawa, V Venkata Su, Y Yahata, M Nakano, S Suzuki, S Suzuki, S Yamada, H Kitaura, I Mizoguchi, Y Noiri, K Handa, M Saito
    Scientific Reports, 2021-01-28;11(1):2613.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction
    Authors: DG Campelj, CA Timpani, AC Petersen, A Hayes, CA Goodman, E Rybalka
    Cancers, 2020-12-17;12(12):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  13. Beige adipocytes contribute to breast cancer progression
    Authors: M Gantov, P Pagnotta, C Lotufo, GM Rindone, MF Riera, JC Calvo, J Toneatto
    Oncology reports, 2020-10-27;45(1):317-328.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  14. Overexpression of microRNA-367 inhibits angiogenesis in ovarian cancer by downregulating the expression of LPA1
    Authors: Q Zheng, X Dai, W Fang, Y Zheng, J Zhang, Y Liu, D Gu
    Cancer Cell Int, 2020-10-02;20(0):476.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm
    Authors: SJ Jeong, MJ Cho, NY Ko, S Kim, IH Jung, JK Min, SH Lee, JG Park, GT Oh
    Exp. Mol. Med., 2020-09-14;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  16. Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis
    Authors: CY Lu, SC Lai, HH Lee, HT Chien, KP Lan, KM Chen
    J Microbiol Immunol Infect, 2020-08-11;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms
    Authors: K Yoshimura, H Aoki, C Teruyama, M Iijima, H Tsutsumi, S Kuroda, K Hamano
    Int J Mol Sci, 2020-08-02;21(15):.
    Species: Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  18. The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain
    Authors: T Osthues, B Zimmer, V Rimola, K Klann, K Schilling, P Mathoor, C Angioni, A Weigert, G Geisslinge, C Münch, K Scholich, M Sisignano
    Cells, 2020-07-21;9(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  19. Gelatinases Cleave Dentin Sialoprotein Intracellularly
    Authors: X Gou, Y Xue, H Zheng, G Yang, S Chen, Z Chen, G Yuan
    Front Physiol, 2020-06-25;11(0):686.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  20. Matrix metalloproteinase 9 facilitates Zika virus invasion of the testis by modulating the integrity of the blood-testis barrier.
    Authors: L Hui, Y Nie, S Li, M Guo, W Yang, R Huang, J Chen, Y Liu, X Lu, Z Chen, Q Yang, Y Wu
    PLoS Pathog, 2020-04-17;16(4):e1008509.
    Species: Mouse, Transgenic Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Immunoprecipitation, Western Blot
  21. Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression
    Authors: K Miteva, D Baptista, F Montecucco, M Asrih, F Burger, A Roth, RA Fraga-Silv, N Stergiopul, F Mach, KJ Brandt
    Sci Rep, 2020-04-01;10(1):5791.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice
    Authors: K Nakajima, M Ono, U Radovi?, S Dizdarevi?, SI Tomizawa, K Kuroha, G Naganatsu, I Hoshi, R Matsunaga, T Shirakawa, T Kurosawa, Y Miyazaki, M Seki, Y Suzuki, H Koseki, M Nakamura, T Suda, K Ohbo
    Dis Model Mech, 2019-11-12;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  23. ATRQ β-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms
    Authors: H Zhang, M Liao, M Cao, Z Qiu, X Yan, Y Zhou, H Wu, Y Wang, J Zheng, J Ding, M Wang, Y Liao, X Chen
    J Am Heart Assoc, 2019-09-12;8(18):e012341.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  24. Carnosic acid alleviates brain injury through NF?κB?regulated inflammation and Caspase?3?associated apoptosis in high fat?induced mouse models
    Authors: Y Liu, Y Zhang, M Hu, YH Li, XH Cao
    Mol Med Rep, 2019-05-27;20(1):495-504.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  25. Platelets isolated from an Alzheimer mouse damage healthy cortical vessels and cause inflammation in an organotypic ex vivo brain slice model
    Authors: KM Kniewallne, BM Foidl, C Humpel
    Sci Rep, 2018-10-19;8(1):15483.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice
    Authors: T Hara, PT Phuong, D Fukuda, K Yamaguchi, C Murata, S Nishimoto, S Yagi, K Kusunose, H Yamada, T Soeki, T Wakatsuki, I Imoto, M Shimabukur, M Sata
    Circulation, 2018-10-16;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  27. MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-?-SMAD3 Signaling
    Authors: X Huang, Z Yue, J Wu, J Chen, S Wang, J Wu, L Ren, A Zhang, P Deng, K Wang, C Wu, X Ding, P Ye, J Xia
    Arterioscler. Thromb. Vasc. Biol., 2018-03-08;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  28. Tea Polysaccharide Prevents Colitis-Associated Carcinogenesis in Mice by Inhibiting the Proliferation and Invasion of Tumor Cells
    Authors: LQ Liu, HS Li, SP Nie, MY Shen, JL Hu, MY Xie
    Int J Mol Sci, 2018-02-08;19(2):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  29. Endotoxemia shifts neutrophils with TIMP-free gelatinase B/ MMP-9 from bone marrow to periphery and induces systematic upregulation of TIMP-1
    Authors: J Vandooren, W Swinnen, E Ugarte-Ber, L Boon, D Dorst, E Martens, G Opdenakker
    Haematologica, 2017-08-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  30. TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
    Authors: ND Thiele, JW Wirth, D Steins, AC Koop, H Ittrich, AW Lohse, J Kluwe
    Sci Rep, 2017-04-06;7(1):714.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  31. Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism
    Authors: M Shimoda, H Yoshida, S Mizuno, T Hirozane, K Horiuchi, Y Yoshino, H Hara, Y Kanai, S Inoue, M Ishijima, Y Okada
    Am. J. Pathol, 2017-03-08;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  32. Smooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries
    Physiol Rep, 2016-12-01;4(23):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  33. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
    Sci Rep, 2016-09-14;6(0):33176.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  34. Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B
    Sci Rep, 2016-07-19;6(0):29852.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  35. Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice.
    Authors: Kato H, Duarte S, Liu D, Busuttil R, Coito A
    PLoS ONE, 2015-09-10;10(9):e0137642.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Cytomegalovirus initiates infection selectively from high-level beta1 integrin-expressing cells in the brain.
    Authors: Kawasaki H, Kosugi I, Sakao-Suzuki M, Meguro S, Arai Y, Tsutsui Y, Iwashita T
    Am J Pathol, 2015-03-19;185(5):1304-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Western Blot
  37. Possible dual role of decorin in abdominal aortic aneurysm.
    Authors: Ueda, Koshiro, Yoshimura, Koichi, Yamashita, Osamu, Harada, Takasuke, Morikage, Noriyasu, Hamano, Kimikazu
    PLoS ONE, 2015-03-17;10(3):e0120689.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  38. Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
    Authors: Dohi, Kenji, Kraemer, Brian C, Erickson, Michelle, McMillan, Pamela J, Kovac, Andrej, Flachbartova, Zuzana, Hansen, Kim M, Shah, Gul N, Sheibani, Nader, Salameh, Therese, Banks, William
    PLoS ONE, 2014-09-24;9(9):e108034.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  39. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
    Authors: Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G
    J Clin Invest, 2014-07-25;124(9):3960-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Platelets guide the formation of early metastatic niches.
    Authors: Labelle, Myriam, Begum, Shahinoo, Hynes, Richard
    Proc Natl Acad Sci U S A, 2014-07-14;111(30):E3053-61.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  41. The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth.
    Authors: Touaitahuata H, Cres G, de Rossi S, Vives V, Blangy A
    Dev Biol, 2014-06-30;393(1):57-70.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice.
    Authors: Duarte, Sergio, Kato, Hiroyuki, Kuriyama, Naohisa, Suko, Kathryn, Ishikawa, Tomo-O, Busuttil, Ronald W, Herschman, Harvey R, Coito, Ana J
    PLoS ONE, 2014-05-12;9(5):e96913.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  43. The omega-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling.
    Authors: Wang J, Eguchi K, Matsumoto S, Fujiu K, Komuro I, Nagai R, Manabe I
    PLoS ONE, 2014-05-05;9(5):e96286.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  44. MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury.
    Authors: Kato H, Kuriyama N, Duarte S, Clavien P, Busuttil R, Coito A
    J Hepatol, 2014-01-08;60(5):1032-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  45. Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis.
    Authors: Muruganandan S, Dranse H, Rourke J, McMullen N, Sinal C
    Stem Cells, 2013-10-01;31(10):2172-82.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  46. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.
    Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N
    Circ Res, 2013-09-30;113(12):1331-44.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  47. KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation.
    Authors: Salmon M, Johnston W, Woo A, Pope N, Su G, Upchurch G, Owens G, Ailawadi G
    Circulation, 2013-09-10;128(11):S163-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  48. CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice.
    Authors: Zhou H, Yan H, Cannon J, Springer L, Green J, Pham C
    J Immunol, 2013-04-12;190(10):5078-85.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.
    J Neuroinflammation, 2012-06-07;9(0):119.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
    Authors: Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
    J. Biol. Chem., 2012-03-23;287(20):16356-64.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  51. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.
    Authors: Kim Y, Remacle AG, Chernov AV
    PLoS ONE, 2012-03-16;7(3):e33664.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Cells
    Applications: ICC, Western Blot
  52. Osteopontin-Stimulated Expression of Matrix Metalloproteinase-9 Causes Cardiomyopathy in the mdx Model of Duchenne Muscular Dystrophy.
    Authors: Dahiya S, Givvimani S, Bhatnagar S
    J. Immunol., 2011-08-01;187(5):2723-31.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  53. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans.
    Authors: Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C
    Diabetologia, 2011-03-25;54(6):1468-79.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  54. Tumor necrosis factor-alpha regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells.
    Authors: Bhatnagar S, Panguluri SK, Gupta SK, Dahiya S, Lundy RF, Kumar A
    PLoS ONE, 2010-10-12;5(10):e13262.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  55. Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1.
    Authors: Xu D, McKee CM, Cao Y
    Cancer Res., 2010-08-24;70(17):6988-98.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  56. TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.
    Authors: Ye Y, Pringle LM, Lau AW
    Oncogene, 2010-04-26;29(25):3619-29.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  57. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
    Authors: Schneider DJ, Lindsay JC, Zhou Y, Molina JG, Blackburn MR
    FASEB J., 2009-08-31;24(1):70-80.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  58. A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.
    Authors: Page K, Ledford JR, Zhou P, Wills-Karp M
    J. Immunol., 2009-08-10;183(5):3400-8.
    Species: Mouse
    Sample Types: BALF
    Applications: Western Blot
  59. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.
    Authors: Hamada T, Duarte S, Tsuchihashi S, Busuttil RW, Coito AJ
    Am. J. Pathol., 2009-05-14;174(6):2265-77.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  60. Molecular role of Cx37 in advanced atherosclerosis: a micro-array study.
    Authors: Derouette JP, Wong C, Burnier L, Morel S, Sutter E, Galan K, Brisset AC, Roth I, Chadjichristos CE, Kwak BR
    Atherosclerosis, 2009-02-27;206(1):69-76.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  61. Matrix metalloproteinase-9 deficiency worsens lung injury in a model of bronchopulmonary dysplasia.
    Authors: Lukkarinen H, Hogmalm A, Lappalainen U, Bry K
    Am. J. Respir. Cell Mol. Biol., 2008-12-18;41(1):59-68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  62. Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.
    Authors: De Palma AM, Verbeken E, Van Aelst I, Van den Steen PE, Opdenakker G, Neyts J
    Virology, 2008-10-16;382(1):20-7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  63. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia.
    Authors: Crocker SJ, Frausto RF, Whitton JL, Milner R
    Glia, 2008-08-15;56(0):1187-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  64. A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis.
    Authors: Morschl E, Molina JG, Volmer JB, Mohsenin A, Pero RS, Hong JS, Kheradmand F, Lee JJ, Blackburn MR
    Am. J. Respir. Cell Mol. Biol., 2008-06-27;39(6):697-705.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  65. Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse.
    Authors: Juncos JP, Tracz MJ, Croatt AJ, Grande JP, Ackerman AW, Katusic ZS, Nath KA
    Kidney Int., 2008-03-26;74(1):47-51.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  66. Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury.
    Authors: Hamada T, Tsuchihashi S, Avanesyan A, Duarte S, Moore C, Busuttil RW, Coito AJ
    J. Immunol., 2008-02-01;180(3):1843-53.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-Fr, Western Blot
  67. Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton.
    Authors: Perri SR, Annabi B, Galipeau J
    FASEB J., 2007-07-10;21(14):3928-36.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  68. Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.
    Authors: Zozulya AL, Reinke E, Baiu DC, Karman J, Sandor M, Fabry Z
    J. Immunol., 2007-01-01;178(1):520-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  69. Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
    Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
    Am. J. Respir. Cell Mol. Biol., 2006-12-01;36(4):442-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  70. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
    Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
    Blood, 2006-11-02;109(5):2234-42.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  71. Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.
    Authors: Ogier C, Bernard A, Chollet AM, LE Diguardher T, Hanessian S, Charton G, Khrestchatisky M, Rivera S
    Glia, 2006-09-01;54(4):272-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  72. Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice.
    Authors: Ramsey KH, Sigar IM, Schripsema JH, Shaba N, Cohoon KP
    Infect. Immun., 2005-10-01;73(10):6962-73.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  73. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
    Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
    Am. J. Respir. Cell Mol. Biol., 2005-05-18;33(3):248-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  74. Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis.
    Authors: Chen KM, Lee HH, Chou HL, Liu JY, Tsai BC, Lai SC
    Int J Exp Pathol, 2005-04-01;86(2):81-9.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-P, Western Blot
  75. Ultrastructural localization of matrix metalloproteinase-9 in eosinophils from the cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis.
    Authors: Tseng YK, Tu WC, Lee HH, Chen KM, Chou HL, Lai SC
    Ann Trop Med Parasitol, 2004-12-01;98(8):831-41.
    Species: Mouse
    Sample Types: CSF
    Applications: Electron Microscopy, Western Blot

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Mouse MMP-9 Antibody
By Xiaoming Zhou on 10/27/2017
Application: WB Sample Tested: Lung tissue Species: Mouse

we tried other mmp9 antibody for mouse, this one works best of all!


Mouse MMP-9 Antibody
By Julie Van on 09/01/2017
Application: WB Sample Tested: Kidney tissue Species: Mouse