Mouse OSMR beta Antibody

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Product Details
Citations (13)
Supplemental Products

Mouse OSMR beta Antibody Summary

Species Reactivity
Detects mouse OSM R beta in direct ELISAs and Western blots.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse OSM R beta
Accession # O70458
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse OSM R beta Fc Chimera (Catalog # 662-OR)
5-15 µg/mL
Immersion fixed frozen sections of mouse embryo (E13.5-15.5)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: OSMR beta

Oncostatin M (OSM) is a member of the IL-6 family of cytokines that share the gp130 as a common signal transducing receptor subunit. Human OSM signals through two types of human OSM receptor complexes: the type I complex comprising the leukemia inhibitory factor receptor beta (LIF R beta ) and gp130, the type II complex made up of OSM receptor beta (OSM R beta ) and gp130. In contrast, mouse OSM signals only through the mouse OSM R beta and gp130 complex. Mouse OSM R beta cDNA encodes a 971 amino acid (aa) residue type I transmembrane protein which contains a 23 aa residue signal peptide, an extracellular domain of 714 aa, a transmembrane domain of 20 aa and a 214 aa cytoplasmic domain. Mouse OSM R beta alone binds mOSM with low-affinity, but forms a high-affinity binding complex in the presence of gp130. Mouse OSM R beta is 55% identical at the amino acid sequence level to human OSM R beta.

  1. Lindberg, R.A. et al. (1998) Mol. Cell. Biol. 18:3357.
  2. Tanaka, M. et al. (1999) Blood 93:804.
Long Name
Oncostatin M Receptor beta
Entrez Gene IDs
9180 (Human); 18414 (Mouse); 310132 (Rat)
Alternate Names
IL-31 receptor subunit beta; IL-31R subunit beta; IL-31RB; IL-31R-beta; Interleukin-31 receptor subunit beta; MGC150627; MGC75127; oncostatin M receptor; oncostatin-M specific receptor beta subunit; oncostatin-M-specific receptor subunit beta; OSM R beta; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1

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Citations for Mouse OSMR beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia
    Authors: Bilgic, SN;Domaniku, A;Toledo, B;Agca, S;Weber, BZC;Arabaci, DH;Ozornek, Z;Lause, P;Thissen, JP;Loumaye, A;Kir, S;
    Species: Transgenic Mouse, Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Essential roles of the cytokine oncostatin M in crosstalk between muscle fibers and immune cells in skeletal muscle after aerobic exercise
    Authors: T Komori, Y Morikawa
    The Journal of Biological Chemistry, 2022-11-09;0(0):102686.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  3. Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice
    Authors: H Lörchner, JM Adrian-Seg, C Waechter, R Wagner, ME Góes, N Brachmann, K Sreenivasa, A Wietelmann, S Günther, N Doll, T Braun, J Pöling
    International Journal of Molecular Sciences, 2021-12-29;23(1):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
    Authors: M Valussi, J Besser, K Wystub-Lis, S Zukunft, M Richter, T Kubin, T Boettger, T Braun
    Science Advances, 2021-10-13;7(42):eabi6648.
    Species: Mouse, Rat, Transgenic Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
    Authors: J Martínez-F, A Prescott, S van Kaster, DL Pedrioli, I McLean, A Moles, T Reinheckel, V Poli, C Watts
    Nat Commun, 2018-12-17;9(1):5343.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Loss of oncostatin M signaling in adipocytes induces insulin resistance and adipose tissue inflammation in vivo
    Authors: Carrie M Elks
    J Biol Chem, 2016-06-20;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.
    Authors: Ehlting C, Bohmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, Knoefel W, Schulte Am Esch J, Haussinger D, Bode J
    Cell Signal, 2015-01-03;27(3):555-67.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  8. Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.
    Authors: Guihard P, Boutet M, Brounais-Le Royer B, Gamblin A, Amiaud J, Renaud A, Berreur M, Redini F, Heymann D, Layrolle P, Blanchard F
    Am J Pathol, 2015-01-02;185(3):765-75.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
    Authors: Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N
    Cytokine, 2014-04-22;68(2):101-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  10. Deficiency of oncostatin M receptor beta (OSMRbeta) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.
    Authors: Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
    J Biol Chem, 2014-04-02;289(20):13821-37.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  11. Lack of oncostatin M receptor beta leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.
    Authors: Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
    J Biol Chem, 2013-06-11;288(30):21861-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.
    Authors: Chollangi, Srinivas, Mather, Timothy, Rodgers, Karla K, Ash, John D
    J Biol Chem, 2012-07-24;287(39):32848-59.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  13. Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS.
    Authors: Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
    J. Biol. Chem., 2011-07-22;286(39):34271-85.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot


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Isotype Controls

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Secondary Antibodies

Goat IgG (H+L) Antibody


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