Tau Antibody Summary
Accession # P10636
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Tau in Human Alzheimer's Disease Brain. Tau was detected in immersion fixed paraffin-embedded sections of human Alzheimer's disease brain (cortex) using 5 µg/mL Goat Anti-Tau Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3494) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Tau is a microtubule-associated protein primarily expressed in neurons. It can associate with microtubules through the carboxy-terminal domains and with the plasma membrane through the amino-terminal projection domain. Tau has a role as a stabilizer of microtubules. Abnormal Tau phosphorylation or splicing is associated with various neurological disorders.
Citation for Tau Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease
Authors: EK Pickett, AG Herrmann, J McQueen, K Abt, O Dando, J Tulloch, P Jain, S Dunnett, S Sohrabi, MP Fjeldstad, W Calkin, L Murison, RJ Jackson, M Tzioras, A Stevenson, M d'Orange, M Hooley, C Davies, M Colom-Cade, A Anton-Fern, D King, I Oren, J Rose, CA McKenzie, E Allison, C Smith, O Hardt, CM Henstridge, GE Hardingham, TL Spires-Jon
Cell Rep, 2019;29(11):3592-3604.e5.
Sample Types: Whole Tissue
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