SLC6A3/DAT1: Products

The dopamine transporter (DAT) is a 70 - 80 kDa member of the Na+-neurotransmitter symporter family of transmembrane (TM) proteins. DAT plays a crucial role in the synaptic clearance of dopamine (DA).

The human dopamine transporter is a 620 amino acid (aa), 12 TM phosphoglycoprotein with an N- and C-terminal cytoplasmic domain. Human DAT exists as a disulfide-linked oligomer on the cell surface. Phosphorylation of the N-terminus (S7/12) promotes DA release. The C-terminus binds CaMKII, as well as Hic5, Pick1, and synuclein which regulate receptor trafficking and expression. There is an extended 71 aa extracellular (EC) loop between TM segments 3 and 4. Glycosylation at this site is necessary for oligomer expression on the cell membrane. The human 42 aa DAT C-terminus is 93% aa identical to the mouse DAT C-terminus. The human EC loop is also 93% aa identical to the rhesus monkey EC loop.

"SLC6A3/DAT1" has 15 results in Products.
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GBR 12909 dihydrochloride 

Selective DA uptake inhibitor; also σ ligand

Nomifensine 

Potent noradrenalin and dopamine uptake inhibitor. Antidepressant

GBR 13069 dihydrochloride 

Potent dopamine uptake inhibitor

GBR 12783 dihydrochloride 

Potent and selective DA uptake inhibitor

GBR 12935 dihydrochloride 

Selective dopamine uptake inhibitor

3-CPMT 

Dopamine uptake inhibitor

3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride 

Potent dopamine uptake inhibitor

Threo-methylphenidate hydrochloride 

Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant

Bupropion hydrochloride 

Non-selective inhibitor of dopamine and noradrenalin transporters

JHW 007 hydrochloride 

High affinity dopamine uptake inhibitor

(R)-Modafinil 

Dopamine uptake inhibitor
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