638 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | KO, IHC, WB, Flow, Dual ISH-IHC, + 1 More |
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Sensitivity: | 8.75 pg/mL |
| Assay Range: | 31.3-2000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Applications: | ELISA |
| Reactivity: | Human |
| Applications: | Simple Plex |
| Reactivity: | Human |
| Reactivity: | Human |
| Source: | NS0 |
| Accession #: | Q8TDQ0 |
| Applications: | Binding Activity |
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2321C |
| Applications: | IHC, WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #344801 |
| Applications: | Func |
| Reactivity: | Human |
| Assay Range: | 62.5-4000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) - Azide and BSA Free [NBP2-79836]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-TIM3-3113-Azide-and-BSA-Free-Immunohistochemistry-Paraffin-NBP2-79836-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) - Azide and BSA Free [NBP2-79836]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
![Western Blot: TIM-3 Antibody (OTI2E2) [NBP2-45933]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-2E2-Western-Blot-NBP2-45933-img0009.jpg "Western Blot: TIM-3 Antibody (OTI2E2) [NBP2-45933]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2E2 |
| Applications: | IHC, WB |
![Western Blot: TIM-3 Antibody (OTI2E2)Azide and BSA Free [NBP2-74520]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-OTI2E2-Azide-and-BSA-Free-Western-Blot-NBP2-74520-img0001.jpg "Western Blot: TIM-3 Antibody (OTI2E2)Azide and BSA Free [NBP2-74520]")
| Reactivity: | Human |
| Details: | Rat IgG2A Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #F38-2E2 |
| Applications: | Flow |
![Flow Cytometry: TIM-3 Antibody (F38-2E2) - BSA Free [NBP2-27220]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-F38-2E2-Flow-Cytometry-NBP2-27220-img0002.jpg "Flow Cytometry: TIM-3 Antibody (F38-2E2) - BSA Free [NBP2-27220]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #F38-2E2 |
| Applications: | Flow, CyTOF-ready |
![Flow Cytometry: TIM-3 Antibody (F38-2E2) - Azide Free [NBP2-27221]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-F38-2E2-Azide-Free-Flow-Cytometry-NBP2-27221-img0004.jpg "Flow Cytometry: TIM-3 Antibody (F38-2E2) - Azide Free [NBP2-27221]")
| Reactivity: | Human |
| Source: | CHO |
| Accession #: | AAL65157.1 |
| Applications: | Bioactivity |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-TIM3-3113-Immunohistochemistry-Paraffin-NBP2-79702-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]")
| Reactivity: | Mouse |
| Details: | Rat IgG2A Monoclonal Clone #215008 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2321B |
| Applications: | mIF, IHC, COMET |
| Reactivity: | Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: TIM-3 Antibody [NB100-56422]](https://resources.rndsystems.com/images/products/TIM-3-Antibody-Western-Blot-NB100-56422-img0002.jpg "Western Blot: TIM-3 Antibody [NB100-56422]")
| Reactivity: | Mouse |
| Source: | NS0 |
| Accession #: | AAL65156 |
| Applications: | Binding Activity |
| Reactivity: | Cynomolgus Monkey |
| Source: | HEK293 |
| Accession #: | EHH54703 |
| Applications: | Binding Activity, Bioactivity |
