Cancer Immunotherapy Dendritic Cell Subsets
Plasmacytoid dendritic cells (pDC) reside in the circulation, extravasate to inflammatory sites, and traffic to draining lymph nodes to initiate adaptive immune responses. Mature pDC induce T cell survival, Th1 bias, cytotoxic T lymphcyte (CTL) activity, natural killer cell (NK) cytotolytic activity, maturation of myeloid DC, and development of plasma cells. They are efficient at antigen cross-presentation and promote cross-presentation by mDC.
| Immature Myeloid DC | ||
| Cell surface | Intracellular | Recruited by |
| CCR1 | DDX1 | CCL2/JE/MCP-1 |
| CCR2 | DDX21 | CCL3/MIP-1 alpha |
| CCR3 | DHX36 | CCL4/MIP-1 beta |
| CCR4 | MARCH1 | CCL5/RANTES |
| CCR5 | NAIP5 | CCL7/MCP-3/MARC |
| CCR6 | NLRC4 | CCL20/MIP-3 alpha |
| CCR8 | NLRP3/NALP3 | CCL25/TECK |
| CLEC4E | RIG-I | CXCL1/GRO alpha/KC/CINC-1 |
| DEC-205/CD205 | CXCL5/ENA-78 | |
| VEGF R1 | CXCL12/SDF-1 | |
| VEGF R2 | ||
| Mature Myeloid DC | ||
| Secreted | Cell surface | Intracellular |
| CCL3/MIP-1 alpha | B7-1/CD80 | TLR3 |
| CCL4/MIP-1 beta | B7-2/CD86 | TLR7 |
| IL-6 | CCR3 | |
| IL-10 | CCR4 | |
| IL-12 | CCR7 | |
| IL-15 | CCR8 | |
| IL-15/IL-15 R Complex | CD1c/BDCA-1 | |
| TNF-alpha | CD40/TNFRSF5 | |
| CD58/LFA-3 | ||
| CD83 | ||
| CLEC9A | ||
| HLA-DR | ||
| ICAM-1/CD54 | ||
| MHC-II (I-A/I-E) | ||
| MMR/CD206 | ||
| Thrombomodulin/BDCA-3 | ||
| TLR4 | ||
| TLR4/MD-2 Complex | ||
| TLR8 | ||
| TLR11 | ||
| TLR13 | ||
| XCR1 | ||
Please see our resources for identifying and characterizing dendritic cell subsets.
Dendritic Cells research area
Dendritic Cell Development, Subsets, and Lineage-specific Markers research area
Dendritic Cells brochure
Mouse & Human Dendritic Cell Subsets poster
Dendritic Cells Developmental Lineage Pathway
Dendritic Cell Maturation mini-review