Human Arylsulfatase A/ARSA Antibody

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Product Details
Citations (1)
Supplemental Products

Human Arylsulfatase A/ARSA Antibody Summary

Species Reactivity
Detects human Arylsulfatase A/ARSA in direct ELISAs and Western blots. In direct ELISAs and Western blots, 20‑50% cross‑reactivity with recombinant mouse ARSA is observed.
Monoclonal Mouse IgG2B Clone # 324802
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human Arylsulfatase A/ARSA
Accession # AAH14210
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

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Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human Arylsulfatase A/ARSA (Catalog # 2485-SU)
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human Arylsulfatase A/ARSA (Catalog # 2485-SU), see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Arylsulfatase A/ARSA

As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms (2). The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507) (3). Human ARSA has a predicted molecular mass of approximately 53 kDa and an apparent molecular mass of approximately 63 kDa in SDS-PAGE. The amino acid sequence of human ARSA shares 92%, 89%, 87%, and 86% identity with porcine, canine, mouse, and rat ARSA.

  1. Lukatela, G. et al. (1998) Biochemistry 37:3654.
  2. Parenti, G. et al. (1997) Curr. Opin. Genet. & Dev. 7:386.
  3. Stein, C. et al. (1989) J. Biol. Chem. 264:1252.
Entrez Gene IDs
410 (Human); 11883 (Mouse)
Alternate Names
ARSA; Arylsulfatase A; ASA; Cerebroside 3-sulfatase; Cerebroside-sulfatase; EC 3.1.6; EC; MLD

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Citation for Human Arylsulfatase A/ARSA Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts
    Authors: K Jäger, J Mensch, ME Grimmig, B Neuner, K Gorzelniak, S Türkmen, I Demuth, A Hartmann, C Hartmann, F Wittig, A Sporbert, A Hermann, G Fuellen, S Möller, M Walter
    Science Advances, 2022;8(33):eabk2814.
    Species: Human
    Sample Types: Cell Lysate
    Applications: Western Blot


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