Human ERR gamma/NR3B3 Antibody

Catalog # Availability Size / Price Qty
PP-H6812-00
Product Details
Citations (7)
FAQs
Supplemental Products
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Human ERR gamma/NR3B3 Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG2a Clone # H6812
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.

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Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
5-15 µg/mL
Perfusion fixed paraffin-embedded sections of rat retina (inner nuclear layer)
Immunoprecipitation
Please refer to the PDF datasheet for specifications.
Direct ELISA
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ERR gamma/NR3B3

Estrogen-related receptor alpha (ERR-alpha, ERR1, ESRL1; NR3B1) is a member of the orphan nuclear receptor family. ERR-alpha is expressed in the liver, kidney, brain, heart, uterus, vagina and cervix. ERR-alpha takes part in the cell cycle and the fatty acid metabolizing of the musculus skeleti. ERR-alpha was shown to interact with ER-alpha. ERR-beta (ERR2; NR3B2) is also expressed in the liver, brain, uterus, vagina, and cervix. ERR-beta has a role in early placental development. ERR-gamma (ESRRG; NR3B3) is expressed in the brain, kidney, testis, lung, adrenal gland, pancreas, placenta and bone marrow. ERR-gamma was shown to be located in the critical region for Usher's syndrome.

Long Name
Estrogen-related Receptor gamma
Entrez Gene IDs
2104 (Human)
Alternate Names
DKFZp781L1617; ERR gamma; ERR gamma-2; ERR3; ERRG2; ERRgamma; ESRRG; Estrogen receptor-related protein 3; estrogen-related receptor gamma; FLJ16023; KIAA0832; NR3B3; Nuclear receptor subfamily 3 group B member 3

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Citations for Human ERR gamma/NR3B3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis
    Authors: C Soulard, C Salsac, K Mouzat, C Hilaire, J Roussel, A Mezghrani, S Lumbroso, C Raoul, F Scamps
    Cell Rep, 2020;30(8):2581-2593.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Origin and Segmental Diversity of Spinal Inhibitory Interneurons
    Authors: LB Sweeney, JB Bikoff, MI Gabitto, S Brenner-Mo, M Baek, JH Yang, EG Tabak, JS Dasen, CR Kintner, TM Jessell
    Neuron, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture Treatment
  3. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling.
    Authors: Kim DK, Kim JR, Koh M, Kim YD, Lee JM, Chanda D, Park SB, Min JJ, Lee CH, Park TS, Choi HS
    J. Biol. Chem., 2012;286(44):38035-42.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRgamma.
    Authors: Lee J, Kim E, Kim D, Lee J, Park S, Lee I, Harris R, Lee M, Choi H
    PLoS ONE, 2012;7(9):e46324.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ChIP
  5. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.
    Authors: Xie YB, Park JH, Kim DK, Hwang JH, Oh S, Park SB, Shong M, Lee IK, Choi HS
    J. Biol. Chem., 2009;284(42):28762-74.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  6. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer.
    Authors: Yu S, Wang X, Ng CF, Chen S, Chan FL
    Cancer Res., 2007;67(10):4904-14.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells.
    Authors: Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R, Bacus SS
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(25):10607-12.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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Isotype Controls

Mouse IgG2A Isotype Control

Secondary Antibodies

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