Human IFN-lambda 4 Antibody

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IFN-lambda 4 in Human Small Intestine.
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Human IFN-lambda 4 Antibody Summary

Species Reactivity
Detects human IFN-lambda 4 in direct ELISAs.
Monoclonal Mouse IgG2B Clone # 991620
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human IFN-lambda 4
Accession # K9M1U5
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
5-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry IFN-?4 antibody in Human Small Intestine by Immunohistochemistry (IHC-P). View Larger

IFN-lambda 4 in Human Small Intestine. IFN-lambda 4 was detected in immersion fixed paraffin-embedded sections of human small intestine using Mouse Anti-Human IFN-lambda 4 Monoclonal Antibody (Catalog # MAB9165) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in epithelial cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IFN-lambda 4

Interferon-lambda 4 (IFN-lambda 4) is a secreted, approximately 17 kDa member of the type III interferon family of molecules (1). It is generated by a frameshift mutation based on a TT > ∆G polymorphism (2). The TT allele inactivates expression of IFN-lambda 4 (2). The ∆G allele is associated with reduced clearance of hepatitis C virus and reduced degranulation of CTL, NK, and NKT cells in the liver during hepatitis (2, 3), although IFN- lambda 4 itself shows in vitro activity against hepatitis C virus (4). IFN-lambda 4 is expressed in the liver of some chronic hepatitis C patients (5). It signals through a receptor complex containing IL-28 R/IFN-lambda R1 and IL-10 R beta to induce the expression of several interferon stimulated genes (ISG) (2, 4). Alternative splicing generates additional isoforms with large internal deletions or a substituted C-terminal region.

  1. Wack, A. et al. (2015) Nat. Immunol. 16:802.
  2. Prokunina-Olsson, L. et al. (2013) Nat. Genet. 45:164.
  3. Jouvin-Marche, E. et al. (2014) J. Infec. Dis. 209:1907.
  4. Hamming, O.J. et al. (2013) EMBO J. 32:3055.
  5. Amanzada, A. et al. (2013) PLoS One 8:e84026.
Long Name
Interferon, Lambda 4
Entrez Gene IDs
101180976 (Human)
Alternate Names
IFNAN; IFNL4; IFNlambda 4; IFN-lambda 4

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Human IFN-lambda 4 Antibody
By Anonymous on 09/10/2022
Application: IHC Sample Tested: Small intestine tissue Species: Human