Human IL-4R alpha Antibody
Human IL-4R alpha Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-4R alpha
Interleukin 4 (IL‑4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. The biological functions of IL‑4 are mediated by the binding of IL‑4 to high‑affinity cell surface receptor complexes. Two types of IL‑4 receptor complexes have been described. The type I IL‑4 receptor complex is composed of a high‑affinity IL‑4‑binding subunit (referred to as IL‑4 R alpha ) and the common gamma chain that does not bind IL‑4 by itself. The type II IL‑4 receptor complex is composed of IL‑4 R alpha and IL‑13 R alpha 1. Besides IL‑4 signals, the type II IL‑4 receptor complex can also transduce IL‑13 signals. In the type II complex, the IL‑4 R alpha subunit binds only IL‑4 and not IL‑13. Similarly, the IL‑13 R alpha 1 subunit binds only IL‑13 and not IL‑4. The cDNA clones for both the human and mouse IL‑4 R alpha have been isolated and shown to encode an approximately 140 kDa type I transmembrane protein with a large cytoplasmic domain that is essential for signal transduction. In mouse cells, an alternatively spliced variant encoding a soluble secreted IL‑4 R alpha isoform has also been identified. Naturally occurring soluble IL‑4 R alpha that binds IL‑4 with high‑affinity has been found in mouse and human biological fluids.
Citation for Human IL-4R alpha Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4.
Authors: Nanni P, Nicoletti G, Palladini A, Astolfi A, Rinella P, Croci S, Landuzzi L, Monduzzi G, Stivani V, Antognoli A, Murgo A, Ianzano M, De Giovanni C, Lollini PL
Mol. Cancer Ther., 2009;8(4):754-61.
Sample Types: Cell Lysates
Applications: Western Blot
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human IL-4R alpha Antibody
There are currently no reviews for this product. Be the first to review Human IL-4R alpha Antibody and earn rewards!
Have you used Human IL-4R alpha Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image