Human INHBE Antibody Summary
Accession # P58166
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of INHBE in Human Liver. INHBE was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human INHBE Monoclonal Antibody (Catalog # MAB11746) at 5 µg/ml overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using the HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: INHBE
Inhibin beta E (INHBE) is a member of the transforming growth factor-beta (TGF-beta ) superfamily of cytokines, with a molecular weight of approximately 40 kDa. INHBE plays critical roles in the regulation of diverse physiological processes, including cell growth, differentiation, and metabolism. It is a key component of the activin signaling pathway, where it dimerizes with other beta -subunits to form bioactive ligands involved in endocrine regulation. INHBE is primarily expressed in hepatic and reproductive tissues and has been implicated in metabolic homeostasis, particularly in energy expenditure and glucose metabolism. Dysregulation of INHBE expression has been linked to pathophysiological conditions such as obesity, insulin resistance, and liver disease. Furthermore, INHBE has gained attention for its tumor-suppressive role in certain cancers, suggesting its potential as a regulator of cell proliferation and apoptosis. Its specificity and involvement in metabolic and oncogenic pathways highlight INHBE as a promising biomarker and a potential target for therapeutic strategies.
- Hedger MP, de Kretser DM. The activins and their binding protein, follistatin-Diagnostic and therapeutic targets in inflammatory disease and fibrosis. Cytokine Growth Factor Rev. 2013 Jun;24(3):285-95. doi: 10.1016/j.cytogfr.2013.03.003. Epub 2013 Mar 29. PMID: 23541927.
- Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A. Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine. Cell Rep. 2018 Oct 30;25(5):1193-1203. doi: 10.1016/j.celrep.2018.10.008. PMID: 30380411.
- Griffin JD, Buxton JM, Culver JA, Barnes R, Jordan EA, White AR, Flaherty SE, Bernardo B, Ross T, Bence KK, Birnbaum MJ. Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids. Mol Metab. 2023 Dec;78:101830. doi: 10.1016/j.molmet.2023.101830. Epub 2023 Oct 28. PMID: 38787338; PMCID: PMC10656223.
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human INHBE Antibody
There are currently no reviews for this product. Be the first to review Human INHBE Antibody and earn rewards!
Have you used Human INHBE Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
