Human Lipin 1 Antibody

Catalog # Availability Size / Price Qty
Lipin 1 in Human Adipocytes.
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Product Details
Citations (5)
Supplemental Products

Human Lipin 1 Antibody Summary

Species Reactivity
Detects human Lipin 1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross‑reactivity with recombinant human (rh) Lipin 2 and rhLipin 3 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant human Lipin 1
Accession # Q14693
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human Lipin 1
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry Lipin 1 antibody in Human Adipocytes by Immunocytochemistry (ICC). View Larger

Lipin 1 in Human Adipocytes. Lipin 1 was detected in immersion fixed human mesenchymal stem cell-derived adipocytes using Goat Anti-Human Lipin 1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3885) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Lipin 1

Lipin 1 is a 100 kDa phosphatidate phosphatase. Mammalian Lipin 1 has been identified as an enzyme that regulates fat metabolism. There is one human Lipin-1. In mice, two Lipin-1 isoforms have been reported, alpha and beta. Lipin 1 alpha is a nuclear protein and is 96% and 98 % identical to human Lipin 1 and rat Lipin 1 alpha, respectively. Lipin 1 beta is cytoplasmic.

Long Name
Phosphatidate Phosphatase LPIN1
Entrez Gene IDs
23175 (Human); 14245 (Mouse); 313977 (Rat)
Alternate Names
DKFZp781P1796; EC; EC; EC; KIAA0188phosphatidate phosphatase LPIN1; Lipin 1; lipin-1; LPIN1; PAP1

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Citations for Human Lipin 1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. UVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes
    Authors: M Chae, ED Son, IH Bae, EG Cho, HJ Kim, JY Jung
    Exp. Mol. Med., 2020;0(0):.
    Species: Human
    Sample Types: Cell Culture Lysates
    Applications: Western Blot
  2. HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver
    Authors: T Arai, M Tanaka, N Goda
    Sci Rep, 2018;8(1):14230.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ChIP
  3. Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase
    Authors: K Ishimoto, A Hayase, F Kumagai, M Kawai, H Okuno, N Hino, Y Okada, T Kawamura, T Tanaka, T Hamakubo, J Sakai, T Kodama, K Tachibana, T Doi
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein e-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.
    Authors: Obama T, Nagaoka S, Akagi K, Kato R, Horiuchi N, Horai Y, Aiuchi T, Arata S, Yamaguchi T, Watanabe M, Itabe H
    PLoS ONE, 2011;6(8):e22917.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
    Authors: Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T
    J. Biol. Chem., 2009;284(33):22195-205.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


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