Human Neurotensin Antibody Summary
Accession # P30990
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Neurotensin in Human Small Bowel. Neurotensin was detected in immersion fixed paraffin-embedded sections of human small bowel using Mouse Anti-Human Neurotensin Monoclonal Antibody (Catalog # MAB11548) at 3 µg/ml for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001) or the HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm of neuroendocrine cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Neurotensin
Neurotensin is a neuropeptide neurotransmitter expressed in both the central and peripheral nervous systems. It acts as a neurotransmitter in the central nervous system and as a hormone in the periphery. This neuropeptide has many roles in the body such as: temperature regulation, feeding, analgesia, ethanol sensitivity, psychosis, substance use, and pain. Neurotensin may also play an endocrine or paracrine role in the regulation of fat metabolism. It is expressed in neuronal synaptic vesicles in the CNS and in the periphery is expressed in the GI tract and in neuroendocrine cells.
- Torruella-Suárez ML, McElligott ZA. Neurotensin in reward processes. Neuropharmacology. 2020 May 1;167:108005. doi: 10.1016/j.neuropharm.2020.108005. Epub 2020 Feb 11. PMID: 32057800; PMCID: PMC7238864.
- Mazella J, Béraud-Dufour S, Devader C, Massa F, Coppola T. Neurotensin and its receptors in the control of glucose homeostasis. Front Endocrinol (Lausanne). 2012 Nov 26;3:143. doi: 10.3389/fendo.2012.00143. PMID: 23230428; PMCID: PMC3515879.
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