Human/Rat SOX10 Antibody
Human/Rat SOX10 Antibody Summary
aa 1-118
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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SOX10 in BG01V Human Embryonic Stem Cells. SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Mouse Anti-Human/Rat SOX10 Monoclonal Antibody (Catalog # MAB2864) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
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SOX10 in Human Melanoma Tissue. SOX10 was detected in immersion fixed paraffin-embedded sections of human melanoma tissue using Mouse Anti-Human/Rat SOX10 Monoclonal Antibody (Catalog # MAB2864) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SOX10
SOX10 belongs to the SOX family of transcription factors which display diverse roles during development. In the central nervous system, SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.
Product Datasheets
Citations for Human/Rat SOX10 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 9
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AKT Signaling Modifies the Balance between Cell Proliferation and Migration in Neural Crest Cells from Patients Affected with Bosma Arhinia and Microphthalmia Syndrome
Authors: C Laberthonn, EM Novoa-Del-, R Chevalier, N Broucqsaul, VV Rao, JP Trani, K Nguyen, S Xue, B Reversade, JD Robin, A Baudot, F Magdinier
Biomedicines, 2021;9(7):.
Species: Human
Sample Types: Whole Cells
Applications: IHC -
Identification and functional analysis of SOX10 phosphorylation sites in melanoma
Authors: JC Cronin, SK Loftus, LL Baxter, S Swatkoski, M Gucek, WJ Pavan
PLoS ONE, 2018;13(1):e0190834.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer
Authors: RC Ching, M Wiberg, PJ Kingham
Stem Cell Res Ther, 2018;9(1):266.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Oligodendroglial maturation is dependent on intracellular protein shuttling.
Authors: Gottle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, Parras C, Kremer D, Hartung H, Cate H, Kury P
J Neurosci, 2015;35(3):906-19.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Perivascular-derived stem cells with neural crest characteristics are involved in tendon repair.
Authors: Xu W, Sun Y, Zhang J, Xu K, Pan L, He L, Song Y, Njunge L, Xu Z, Chiang M, Sung K, Chuong C, Yang L
Stem Cells Dev, 2015;24(7):857-68.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous system.
Authors: Coquenlorge S, Duchalais E, Chevalier J, Cossais F, Rolli-Derkinderen M, Neunlist M
J Neuroinflammation, 2014;11(1):202.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia.
Authors: Jacob C, Lotscher P, Engler S, Baggiolini A, Varum Tavares S, Brugger V, John N, Buchmann-Moller S, Snider P, Conway S, Yamaguchi T, Matthias P, Sommer L, Mantei N, Suter U
J Neurosci, 2014;34(17):6112-22.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells.
Authors: Jacob C, Christen CN, Pereira JA, Somandin C, Baggiolini A, Lotscher P, Ozcelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P, Suter U
Nat. Neurosci., 2011;14(4):429-36.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin.
Authors: Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S
Stem Cells, 2007;26(1):163-72.
Species: Human
Sample Types: Whole Cells
Applications: ICC
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