Human SOST/Sclerostin Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (7)
Supplemental Products

Human SOST/Sclerostin Antibody Summary

Species Reactivity
Detects human SOST/Sclerostin in ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse SOST is observed.
Monoclonal Mouse IgG2B Clone # 220902
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin
Accession # Q9BQB4
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Complete Your Experiment


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human SOST/Sclerostin (Catalog # 1406-ST)

Human SOST Sandwich Immunoassay

Recommended Concentration
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human SOST/Sclerostin Biotinylated Antibody (Catalog # BAM14061)

Standard: Recombinant Human SOST/Sclerostin Protein (Catalog # 1406-ST)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOST/Sclerostin

SOST, also known as sclerostin, belongs to the Cerberus/DAN family of secreted glycoproteins. SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity and functions in bone homeostasis as a BMP antagonist.

Entrez Gene IDs
50964 (Human); 74499 (Mouse)
Alternate Names
sclerostin; SOST; VBCHsclerosteosis

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Citations for Human SOST/Sclerostin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
    Authors: CJM Stapledon, H Tsangari, LB Solomon, DG Campbell, P Hurtado, R Krishnan, GJ Atkins
    PLoS ONE, 2019;14(9):e0222602.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  2. Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients.
    Authors: Pereira R, Juppner H, Gales B, Salusky I, Wesseling-Perry K
    PLoS ONE, 2015;10(3):e0120856.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. Altered Osteocyte-Specific Protein Expression in Bone after Childhood Solid Organ Transplantation.
    Authors: Pereira R, Valta H, Tumber N, Salusky I, Jalanko H, Makitie O, Wesseling Perry K
    PLoS ONE, 2015;10(9):e0138156.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  4. Regulation of circulating sclerostin levels by sex steroids in women and in men.
    Authors: Modder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, Riggs BL, Khosla S
    J. Bone Miner. Res., 2011;26(1):27-34.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development
  5. Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro.
    Authors: Jager A, Gotz W, Lossdorfer S, Rath-Deschner B
    J. Periodont. Res., 2010;45(2):246-54.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
    Authors: Jilka RL, O'Brien CA, Bartell SM, Weinstein RS, Manolagas SC
    J. Bone Miner. Res., 2010;25(11):2427-37.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  7. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis.
    Authors: Appel H, Ruiz-Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, Haibel H, Baraliakos X, Hempfing A, Rudwaleit M, Sieper J, Schett G
    Arthritis Rheum., 2009;60(11):3257-62.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development


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