Human SOST/Sclerostin Antibody
Human SOST/Sclerostin Antibody Summary
Gln24-Tyr213
Accession # Q9BQB4
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Applications
Human SOST Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SOST/Sclerostin
SOST, also known as sclerostin, belongs to the Cerberus/DAN family of secreted glycoproteins. SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity and functions in bone homeostasis as a BMP antagonist.
Product Datasheets
Citations for Human SOST/Sclerostin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
Authors: CJM Stapledon, H Tsangari, LB Solomon, DG Campbell, P Hurtado, R Krishnan, GJ Atkins
PLoS ONE, 2019;14(9):e0222602.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients.
Authors: Pereira R, Juppner H, Gales B, Salusky I, Wesseling-Perry K
PLoS ONE, 2015;10(3):e0120856.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Altered Osteocyte-Specific Protein Expression in Bone after Childhood Solid Organ Transplantation.
Authors: Pereira R, Valta H, Tumber N, Salusky I, Jalanko H, Makitie O, Wesseling Perry K
PLoS ONE, 2015;10(9):e0138156.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Regulation of circulating sclerostin levels by sex steroids in women and in men.
Authors: Modder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, Riggs BL, Khosla S
J. Bone Miner. Res., 2011;26(1):27-34.
Species: Human
Sample Types: Serum
Applications: ELISA Development -
Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro.
Authors: Jager A, Gotz W, Lossdorfer S, Rath-Deschner B
J. Periodont. Res., 2010;45(2):246-54.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
Authors: Jilka RL, O'Brien CA, Bartell SM, Weinstein RS, Manolagas SC
J. Bone Miner. Res., 2010;25(11):2427-37.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis.
Authors: Appel H, Ruiz-Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, Haibel H, Baraliakos X, Hempfing A, Rudwaleit M, Sieper J, Schett G
Arthritis Rheum., 2009;60(11):3257-62.
Species: Human
Sample Types: Serum
Applications: ELISA Development
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