N-Me-6,7-diOH-TIQ Antibody

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N-Me-6,7-diOH-TIQ Antibody Summary

Recognizes N‑Me‑6,7‑diOH‑TIQ in immunoassays. The specificity was determined by a competition type assay where the N‑Me‑6,7‑diOH‑TIQ labeled with biotin at position 5 or 8 competed with another compound for binding to the antibody binding site. The detection limit of biotinylated N‑Me‑6,7‑diOH‑TIQ in assays where the molecule was captured by the antibody coated on microplates and developed by HRP‑streptavidin was 5 nM. The dissociation constants of the interaction between the antibody and N‑Me‑6,7‑diOH‑TIQ and its biotinylated analog were 0.2 and 0.5 µM, respectively. This antibody specifically recognizes N‑Me‑6,7‑diOH‑TIQ and shows 60% cross‑reactivity with 6,7‑diOH‑TIQ, 15% cross‑reactivity with 1,N‑di‑Me‑6,7‑diOH‑TIQ, 3% cross‑reactivity with 1‑Me‑6,7‑diOH‑TIQ, and less than 1% or no cross‑reactivity with tetrahydroisoquinoline (TIQ), 5‑OH‑isoquiniline, 5‑OH‑N‑Me‑isoquinolinium, tetrahydropapaveroline, 9H‑pyrido[3,4‑b]indole, and 1,2,3,4‑tetrahydro‑9H‑pyrido[3,4‑b]indole. The percent cross‑reactivity is expressed by the relative value, which produced 50% inhibition of interaction between the biotin‑labeled N‑methyl‑6,7‑dihydroxytetrahydroisoquinoline and the other compound.
Monoclonal Mouse IgG2B Clone # 106814
Protein A or G purified from ascites
Carrier protein-coupled N‑Me‑6,7-diOH-TIQ
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

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Recommended Concentration
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human Alzheimer's disease brain

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
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The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: N-Me-6,7-diOH-TIQ

Tetrahydroisoquinolines (TIQs) are structurally similar to MPTP, an agent known to cause Parkinsonism. TIQs may play a role in pathogenesis of Parkinson's Disease.

Alternate Names
7diOHTIQ; NMe6; N-Me-6,7-diOH-TIQ

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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