CEACAMs: Adhesion Molecules as Novel Targets for Cancer Therapies
Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) form part of the CEA protein family consisting of CEACAMs and the pregnancy-specific glycoproteins (PSGs). CEACAMs are Ig superfamily proteins encoded by 12 genes on human chromosome 19q13 and display diverse evolution, with only 5 CEACAMs conserved among mouse, rat, and human.
Originally described as a biomarker for colorectal cancer, CEACAMs have now been associated with a wide range of intracellular signaling processes and specific expression patterns. CEACAM-3 was identified as critical for opsonin-independent phagocytosis and bacterial clearance, whereas CEACAM-16 has been linked to autosomal dominant nonsyndromic deafness (ADNSHL). Additionally, CEACAM-1, CEACAM-5, CEACAM-6, and CEACAM-19 have been studied for their role in multiple cancers, with special interest as CAR-T targets. CEACAM family members have been shown to bind each other and have been described as receptors for Tim-3, galectins, and integrins.
R&D systems now offers products for the complete range of human CEACAM molecules for your research needs.
| Proteins | Species | Source | Tag | Catalog # | Bioactivity |
|---|---|---|---|---|---|
| CEACAM-1/CD66a | Human | NS0 | His | 2244-CM | Inhibits IL-2 secretion by HuT 78 T cell lymphoma cells |
| Human | CHO | His, Avi-tag | AVI2244 | Binds CEACAM-5/CD66e (Catalog # 10449-CM) | |
| Human | HEK293 | Fc, Avi-tag | AVI11074 | Binds CEACAM-1/CD66a (Catalog # 2244-CM) | |
| CEACAM-3 | Human | CHO | Fc | 9985-CM | Binds CEACAM-7 (Catalog # 9010-CM) |
| Human | NS0 | His | 9868-CM | ||
| CEACAM-5 | Human | NS0 | His | 4128-CM | Binds Galectin-4 (Catalog # 1227-GA) |
| Human | CHO | His, Avi-tag | AVI4128 | ||
| Human | HEK293 | Fc | 10449-CM | ||
| Human | CHO | Fc, Avi-tag | AVI10449 | ||
| Mouse | NS0 | Fc | 10403-CM | Binds Galectin-4 (Catalog # 2128-GA) | |
| Mouse | NS0 | His | 10404-CM | ||
| CEACAM-6 | Human | NS0 | His | 3934-CM | Supports adhesion of calcium ionophore treated neutophils |
| Human | CHO | Fc, Avi-tag | AVI10928 | Binds CEACAM-8/CD66b (Catalog # 9639-CM) | |
| CEACAM-7 | Human | CHO | His | 9010-CM | Binds CEACAM-1/CD66a (Catalog # 2244-CM) |
| CEACAM-8 | Human | NS0 | His | 9639-CM | Binds Galectin-3 (Catalog # 1154-GA) |
| CEACAM-16 | Human | CHO | HA | 9885-CM | |
| CEACAM-18 | Human | HEK293 | Fc | 9869-CM | Binds Galectin-3 (Catalog # 8259-GA) |
| CEACAM-19 | Human | HEK293 | Fc | 9397-CM | Supports adhesion of mouse fibroblasts |
| CEACAM-20 | Human | CHO | Fc | 9427-CM | Supports adhesion of mouse fibroblasts |
| Human | HEK293 | His | 10277-CM | ||
| Mouse | NS0 | His | 10953-CM | ||
| CEACAM-21 | Human | CHO | Fc | 9870-CM | Binds Galectin-3 (Catalog # 8259-GA) |
CEACAM Bioactivity QC Testing
CEACAM-21 Binds to Galectin-3. When Recombinant Human Galectin-3 (Catalog # 8259-GA) is coated at 1 ug/mL, Recombinant Human CEACAM-21 Fc Chimera (Catalog # 9870-CM) binds with an ED50 approximately 150 ng/mL.
CEACAM-3 Binds to CEACAM-7. When Recombinant Human CEACAM-3/CD66d (Catalog # 9868-CM) is coated on to a tissue culture plate at 2 ug/mL Recombinant Human CEACAM-7 (Catalog # 9010-CM) binds with an ED50 of approximately 1 ug/mL.
CEACAM-19 enhances adhesion of mouse fibroblasts. Immobilized Recombinant Human CEACAM-19 (Catalog # 9397-CM) increases cell adhesion of mouse fibroblast L cells. The ED50 for this effect is 0.4-2.4 μg/mL.
View other Immune-checkpoint blockade targets
Related Pathways
- T Cell Co-Signaling Pathway: Ligand-Receptor Interactions
- Mechanisms of Regulatory T Cell-Mediated Suppression
Other immune-checkpoint blockade resources:
- Immune Checkpoint
- Immune Checkpoint Blockade: Immune Checkpoint Molecule Expression
- Immune Checkpoint Blockade: Immune Cell Phenotyping and Isolation
- VSIG8 Poster: Co-inhibitory Immune Checkpoint Molecule
- Webinar Short: B7-related Butryophilins as Immune Modulators
- Immunotherapy
- A Role for VSIG-3/VISTA Signaling in Acquired Resistance to Anti-PD-1 Therapy?