Recombinant Cynomolgus Monkey and Rhesus Macaque Proteins
Cynomolgus Monkey and Rhesus Macaque are the most widely used nonhuman primate animal models covering a range of research areas and pathologies such as immunology, neurology, reproduction, Parkinson's disease, stroke, malaria, infectious disease, genetics, xenotransplantation, and drug abuse. Because of the high degree of genetic similarity to humans, cynomolgus monkey is a popular model of choice for immunotherapy researchers interested in the field of checkpoint immunology. They are also used in toxicology and drug efficacy studies by the pharmaceutical industry.
R&D Systems offers an expanding line of Recombinant Cynomolgus Monkey proteins and Rhesus Macaque proteins. Like all R&D Systems proteins, our recombinant proteins are put through rigorous quality control to ensure the highest bioactivity, purity, and lot-to-lot consistency. In addition, if you do not see your protein of interest, the R&D Systems Custom Protein Development Team can work with you to create a customized protein solution to meet your specific research needs.
Non-Human Primate Proteins - Cynomolgus Monkey and Rhesus Macaque Proteins
Immuno-Oncology Proteins
Cytokines and Cytokine Receptors
Non-Human Primate Protein Data
Bioactivity
Recombinant Rhesus Macaque IL-18/IL-1F4 (Catalog # 2548-RM) induces IFN-gamma secretion by KG-1 human acute myelogenous leukemia cells in the presence of TNF-alpha. The ED50 for this effect is 1-4 ng/mL.
Immobilized Recombinant Cynomolgus Monkey Siglec‑2/CD22 (Catalog # 9864-SL) supports the adhesion of human red blood cells.The ED50 for this effect is 0.07-0.42 μg/mL.
Recombinant Cynomolgus/Rhesus Macaque BCMA Fc Chimera(Catalog # 10029-BC) inhibits Recombinant Human APRIL/TNFSF13 (Catalog #5860-AP) mediated proliferation of anti-IgM stimulated mouse B cells. The ED50 for this effectis 30-180 ng/mL.
Binding Activity
When Recombinant Cynomolgus Monkey PD-L1/B7-H1 (Catalog # 10145-B7) is immobilized at 1 µg/mL, Recombinant Cynomolgus Monkey PD-1 Fc Chimera(Catalog # 8578-PD) binds with an ED50of15-75 ng/mL.
When Recombinant Cynomolgus Monkey CD155/PVR Fc Chimera (Catalog # 10058-CD) is coated at 5 μg/mL, 100 μL/well, Recombinant Human CD96v2 Fc Chimera (Catalog # 9556-CD) binds with an ED50 of 0.25-1.25 μg/mL.
When Recombinant Cynomolgus Monkey B7-1/CD80 (Catalog # 9244-B1) is immobilized at 0.5 µg/mL (100 µL/well), Recombinant Human CTLA-4 Fc Chimera(Catalog # 7268-CT) binds with an ED50 of 5-30 ng/mL.
SDS-PAGE
2 μg/lane of Recombinant Cynomolgus Monkey VSIG4 Fc Chimera (Catalog # 10155-VS) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie Blue staining, showing bands at 67-76 kDa and 130-150 kDa, respectively.
2 μg/lane of Recombinant Cynomolgus Monkey Angiopoietin‑like Protein 3/ANGPTL3 (Catalog # 10052-AN) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie Blue staining, showing bands at 56-65 kDa.
2 μg/lane of Recombinant Cynomolgus Monkey LAG‑3 (Catalog # 9992-L3) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie Blue staining, showing bands at 45-61 kDa.
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