Ligases

Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.

Ligase Target Files

Ubiquitin-activating Enzyme E1

Ubiquitin/Ubl E2 Conjugating Enzymes

Ubiquitin E3 Ligases

Related Targets

DNA, RNA and Protein Synthesis

IRE1 (IRE1)

DNA-Dependent Protein Kinase

Other Ligases

Exonucleases

 

Ligase Gene Data

GeneSpeciesGene SymbolGene Accession No.Protein Accession No.
MDM2HumanMDM2NM_006880Q53XW0
MouseMdm2NM_010786P23804
RatMdm2NM_001108099XP_235169
DNA Ligase IHumanLIG1NM_000234P18858
MouseLig1NM_001083188P37913
RatLig1NM_030855Q9JHY8
DNA Ligase IIIHumanLIG3NM_013975P49916
MouseLig3NM_010716P97386
DNA Ligase IVHumanLIG4NM_002312P49917
MouseLig4NM_176953Q8BTF7