168 results for "GSK-3 beta" in Products
GSK-3 beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% |
CHIR 99021 synthesized to cGMP guidelines
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥99% |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG2A Monoclonal Clone #3D10 |
| Applications: | IHC, WB, ELISA, Flow, ICC/IF, + 1 More |
![Western Blot: GSK-3 beta Antibody (3D10)BSA Free [NBP1-47470]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-3D10-Western-Blot-NBP1-47470-img0012.jpg "Western Blot: GSK-3 beta Antibody (3D10)BSA Free [NBP1-47470]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Mouse, Rat, Mammal |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![GSK-3 beta [p Tyr279, p Tyr216] Antibody](https://resources.rndsystems.com/images/products/nb100-81946_rabbit-polyclonal-gsk-3-beta-p-tyr216-antibody-23420241523259.jpg "Immunohistochemistry-Paraffin: GSK-3 beta [p Tyr279, p Tyr216] Antibody [NB100-81946] -")
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Mouse IgG2A Monoclonal Clone #3D10 |
| Applications: | IHC, WB, ELISA, Flow, ICC/IF, + 2 More |
![Western Blot: GSK-3 beta Antibody (3D10)Azide and BSA Free [NBP2-80757]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-3D10-Azide-and-BSA-Free-Western-Blot-NBP2-80757-img0002.jpg "Western Blot: GSK-3 beta Antibody (3D10)Azide and BSA Free [NBP2-80757]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Flow, ICC/IF, CyTOF-ready |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2B Monoclonal Clone #272536 |
| Applications: | WB, Flow, ICC/IF, CyTOF-ready |
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
| Alternate Names: | CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride |
| Purity: | ≥98% |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
Inhibitor of protein synthesis
| Chemical Name: | 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione |
| Purity: | ≥97% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta Antibody [NBP1-31353]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-Western-Blot-NBP1-31353-img0015.jpg "Western Blot: GSK-3 beta Antibody [NBP1-31353]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #GT1619 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta Antibody (GT1619) [NBP3-13691]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-GT1619-Western-Blot-NBP3-13691-img0008.jpg "Western Blot: GSK-3 beta Antibody (GT1619) [NBP3-13691]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2B Monoclonal Clone #833916 |
| Applications: | WB, ICC/IF |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #609739 |
| Applications: | WB, Flow, ICC/IF, CyTOF-ready |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1253C |
| Applications: | WB, ICC/IF, Simple Western |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2A Monoclonal Clone #GT16711 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 beta Antibody (GT16711) [NBP3-13679]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-GT16711-Western-Blot-NBP3-13679-img0005.jpg "Western Blot: GSK-3 beta Antibody (GT16711) [NBP3-13679]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #3D6B4 |
| Applications: | IHC, WB, ELISA, Flow, CyTOF-ready |
![Western Blot: GSK-3 beta Antibody (3D6B4)BSA Free [NBP2-52478]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-3D6B4-Western-Blot-NBP2-52478-img0004.jpg "Western Blot: GSK-3 beta Antibody (3D6B4)BSA Free [NBP2-52478]")
| Reactivity: | Human |
| Source: | Sf 9 (baculovirus) |
| Accession #: | NM_001145156 |
| Applications: | Bioactivity |
| Reactivity: | Human, Mouse, Rat |
| Assay Range: | 156-10000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rat IgG2B Monoclonal Clone #272535 |
| Applications: | ICC/IF |
| Reactivity: | Human |
| Source: | HEK293 |
| Accession #: | P49841.2 |
| Applications: | Enzyme Activity |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: GSK-3 beta Antibody [NBP1-90359]](https://resources.rndsystems.com/images/products/GSK-3-beta-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-90359-img0007.jpg "Immunocytochemistry/ Immunofluorescence: GSK-3 beta Antibody [NBP1-90359]")