Proteome Profiler Human Phospho-RTK Array Kit

Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Catalog # Availability Size / Price Qty
ARY001B
Product Details
Citations (160)
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Proteome Profiler Human Phospho-RTK Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative phosphorylation of human receptor tyrosine kinases. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously
  • Requires no specialized equipment
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-RTK Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple receptors in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 
Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Anti-Phospho-Tyrosine-HRP Detection Antibody
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these RTKs in a single sample
ALK/CD246 EphB4 MuSK
Axl EphB6 PDGF R alpha
DDR1 ErbB2 PDGF R beta
DDR2 ErbB3 c-Ret
Dtk ErbB4 ROR1
EGF R FGF R1 ROR2
EphA1 FGF R2 alpha Ryk
EphA2 FGF R3 SCF R/c-kit
EphA3 FGF R4 Tie-1
EphA4 Flt-3/Flk-2 Tie-2
EphA5 HGF R/c-MET TrkA
EphA6 IGF-I R TrkB
EphA7 Insulin R/CD220 TrkC
EphA10 M-CSF R VEGF R1/Flt-1
EphB1 Mer VEGF R2/KDR
EphB2 MSP R/Ron VEGF R3/Flt-4
EphB3    
 

Assays for Analytes represented in the Proteome Profiler Human Phospho-RTK Array Kit

 
Analyte Quantikine® ELISA Kits DuoSet® ELISA Development System DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits
ALK/CD246          
Axl   DY154 DYC1643    
DDR1     DYC2396 DYC5859  
DDR2     DYC2538 DYC6170  
Dtk   DY859      
EGF R DEGFR0 DY231 DYC1854 DYC1095B  
EphA1     DYC638    
EphA2     DYC3035 DYC4056  
EphA3          
EphA4     DYC3038 DYC4057  
EphA5          
EphA6          
EphA7          
EphA10          
EphB1          
EphB2          
EphB3          
EphB4     DYC3038 DYC4057  
ErbB2   DY1129 DYC1129 DYC1768  
ErbB3   DY348 DYC234 DYC1769 KCB5677
ErbB4     DYC1133 DYC2115
ErbB6          
FGF R1       DYC5079  
FGF R2 alpha     DYC665 DYC684  
FGF R3     DYC766 DYC2719  
FGF R4     DYC685 DYC5516  
Flt-3/Flk     DYC912 DYC368  
HGF R/c-MET   DY358 DYC358 DYC2480  
IGF-I R   DY391 DYC305 DYC1770  
Insulin R/CD220     DYC1544 DYC2718  
M-CSF R   DY329 DYC329 DYC3268  
Mer   DY6488 DYC891 DYC2579  
MSP R/Ron     DYC691 DYC1947  
MuSK          
PDGF R alpha     DYC322 DYC2114  
Ret          
ROR1          
ROR2          
Ryk          
PDGF R beta     DYC385 DYC1767  
DYC3096  
SCF R/c-kit DSCR00 DY332 DYC332 DYC3527  
Tie-1   DY5907      
Tie-2 DTE200 DY5159   DCY2720  
TrkA     DYC175 DYC2578  
TrkB     DYC397 DYC688  
TrkC     DYC373    
VEGF R1/Flt-1 DVR100B DY321B   DYC4170  
VEGF R2/KDR DVR200 DY357 DYC1780 DYC1766  
VEGF R3/Flt-4   DY349 DYC3491 DYC2724  
 
Data Examples
Figure 1. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes.
View Larger Image

Figure 1. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment.

Figure 2. The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition.
View Larger Image

Figure 2. The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. MDA-MB-453 human breast cancer cells were treated with 100 ng/mL of rhNRG1-beta1/HRG1-beta1 (R&D Systems, Catalog # 396-HB) for 5 minutes. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor.

Product Datasheets

Preparation and Storage

Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: RTK Assay Kits

Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane proteins that act as receptors for growth factors, neurotrophic factors, and other extracellular signaling molecules. Upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail. This leads to the binding of protein substrates and/or the establishment docking sites for adaptor proteins involved in RTK-mediated signal transduction. RTKs have critical functions in several developmental processes including regulating cell survival, proliferation, and motility. When unregulated, they play prominent roles in cancer formation. R&D Systems offers several different multiplex assay formats that allow the user to assess the activity of many RTKs in a single sample. Available RTK multiplex kits include bead-based multiplex kits for the Luminex platform, membrane-based antibody arrays, and microplate-based antibody arrays.

Alternate Names
RTK Assay Kits

Citations for Proteome Profiler Human Phospho-RTK Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

160 Citations: Showing 1 - 10
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  1. Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo
    Authors: S Boichuk, A Galembikov, P Dunaev, E Micheeva, E Valeeva, M Novikova, N Khromova, P Kopnin
    Molecules, 2018;23(10):.  2018
  2. Identification of FDA-approved oncology drugs with selective potency in high-risk childhood ependymoma
    Authors: AM Donson, V Amani, EA Warner, AM Griesinger, DA Witt, JM Mulcahy Le, LM Hoffman, TC Hankinson, MH Handler, R Vibhakar, K Dorris, NK Foreman
    Mol. Cancer Ther., 2018;0(0):.  2018
  3. BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines
    Authors: R Herr, S Halbach, M Heizmann, H Busch, M Boerries, T Brummer
    Oncogene, 2018;0(0):.  2018
  4. Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers
    Authors: H Kotani, Y Adachi, H Kitai, S Tomida, H Bando, AC Faber, T Yoshino, DC Voon, S Yano, H Ebi
    Oncogene, 2018;0(0):.  2018
  5. BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC
    Authors: B Leonard, TM Brand, RA O'Keefe, E Lee, Y Zang, JD Kemmer, H Li, JR Grandis, NE Bhola
    Cancer Res., 2018;0(0):.  2018
  6. MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib
    Authors: K Ninomiya, K Ohashi, G Makimoto, S Tomida, H Higo, H Kayatani, T Ninomiya, T Kubo, E Ichihara, K Hotta, M Tabata, Y Maeda, K Kiura
    Sci Rep, 2018;8(1):1955.  2018
  7. Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
    Authors: B Haas, V Klinger, C Keksel, V Bonigut, D Kiefer, J Caspers, J Walther, M Wos-Magang, S Weickhardt, G Röhn, M Timmer, R Frötschl, N Eckstein
    Cancer Cell Int., 2018;18(0):69.  2018
  8. Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
    Authors: F Mao, C Holmlund, M Faraz, W Wang, T Bergenheim, S Kvarnbrink, M Johansson, R Henriksson, H Hedman
    Oncogenesis, 2018;7(2):13.  2018
  9. A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
    Authors: AH Daneshmane, M Hojjat-Far, A Ghaderi, A Moshfegh, L Hansson, J Schultz, J Vågberg, S Byström, E Olsson, T Olin, A Österborg, H Mellstedt
    PLoS ONE, 2018;13(6):e0198038.  2018
  10. LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals
    Authors: SN Jung, HS Lim, L Liu, JW Chang, YC Lim, KS Rha, BS Koo
    Sci Rep, 2018;8(1):2718.  2018
  11. Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
    Authors: SA Greenall, J Donoghue, TG Johns, TE Adams
    Transl Oncol, 2018;11(4):971-978.  2018
  12. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018;47(5):1751-1768.  2018
  13. HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation
    Authors: S Sun, Y Zhang, J Zheng, B Duan, J Cui, Y Chen, W Deng, B Ye, L Liu, Y Chen, J Du, L Gu
    Cell Death Dis, 2018;9(9):929.  2018
  14. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038.  2018
  15. Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-Tissue Sarcoma: Potential Therapeutic implication for Synovial Sarcoma
    Authors: PP Patwardhan, E Musi, GK Schwartz
    Mol. Cancer Ther., 2018;0(0):.  2018
  16. Altered Met Receptor Phosphorylation and LRP1 Mediated Uptake in Cells Lacking Carbohydrate-Dependent Lysosomal Targeting
    Authors: M Aarnio-Pet, P Zhao, SH Yu, C Christian, H Flanagan-S, L Wells, R Steet
    J. Biol. Chem., 2017;0(0):.  2017
  17. Dual�Targeting�of�Insulin�Receptor�and�KIT�in�Imatinib-Resistant�Gastrointestinal�Stromal�Tumors
    Authors: W Chen, Y Kuang, HB Qiu, Z Cao, Y Tu, Q Sheng, G Eilers, Q He, HL Li, M Zhu, Y Wang, R Zhang, Y Wu, F Meng, JA Fletcher, WB Ou
    Cancer Res., 2017;0(0):.  2017
  18. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017;0(0):.  2017
  19. Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
    Authors: K Miyata, A Takemoto, S Okumura, M Nishio, N Fujita
    Sci Rep, 2017;7(1):4059.  2017
  20. Amplification of EGFR wild type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors
    Authors: S Nukaga, H Yasuda, K Tsuchihara, J Hamamoto, K Masuzawa, I Kawada, K Naoki, S Matsumoto, S Mimaki, S Ikemura, K Goto, T Betsuyaku, K Soejima
    Cancer Res, 2017;0(0):.  2017
  21. Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications
    Authors: SS Yadav, J Li, JA Stockert, B Herzog, J O'Connor, L Garzon-Man, R Parsons, AK Tewari, KK Yadav
    Transl Oncol, 2017;10(3):357-366.  2017
  22. Piperlongumine downregulates the expression of HER family in breast cancer cells
    Authors: HO Jin, JA Park, HA Kim, YH Chang, YJ Hong, IC Park, JK Lee
    Biochem. Biophys. Res. Commun., 2017;0(0):.  2017
  23. Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS
    Authors: E Saintas, L Abrahams, GT Ahmad, AM Ajakaiye, AS AlHumaidi, C Ashmore-Ha, I Clark, UK Dura, CN Fixmer, C Ike-Morris, M Mato Prado, D Mccullough, S Mishra, KM Schöler, H Timur, MD Williamson, M Alatsatian, B Bahsoun, E Blackburn, CE Hogwood, PE Lithgow, M Rowe, L Yiangou, F Rothweiler, J Cinatl, R Zehner, AJ Baines, MD Garrett, CW Gourlay, DK Griffin, WJ Gullick, E Hargreaves, MJ Howard, DR Lloyd, JS Rossman, CM Smales, AD Tsaousis, T von der Ha, MN Wass, M Michaelis
    PLoS ONE, 2017;12(2):e0172140.  2017
  24. Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol
    Authors: HE Pearson, M Iida, RA Orbuch, NK McDaniel, KP Nickel, RJ Kimple, J Arbiser, DL Wheeler
    Mol. Cancer Ther., 2017;0(0):.  2017
  25. Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
    Authors: R Mansouri, Y Jouan, E Hay, C Blin-Wakka, M Frain, A Ostertag, C Le Henaff, C Marty, V Geoffroy, PJ Marie, M Cohen-Sola, D Modrowski
    Cell Death Dis, 2017;8(6):e2902.  2017
  26. In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines
    Authors: L Klameth, B Rath, G Hamilton
    J Cancer, 2017;8(10):1733-1743.  2017
  27. Insulin-like Growth Factor-1 signalling is essential for Mitochondrial Biogenesis and Mitophagy in cancer cells
    Authors: A Lyons, M Coleman, S Riis, C Favre, CH O'Flanagan, AV Zhdanov, DB Papkovsky, SD Hursting, R O'Connor
    J. Biol. Chem., 2017;0(0):.  2017
  28. Mechanisms of primary drug resistance in FGFR1 amplified lung cancer
    Authors: F Malchers, MS Ercanoglu, D Schütte, R Castiglion, V Tischler, S Michels, I Dahmen, J Brägelmann, R Menon, JM Heuckmann, J George, S Ansén, ML Sos, A Soltermann, M Peifer, J Wolf, R Büttner, RK Thomas
    Clin. Cancer Res., 2017;0(0):.  2017
  29. mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism
    Authors: A Lampada, J O'Prey, G Szabadkai, KM Ryan, D Hochhauser, P Salomoni
    Cell Death Differ., 2017;0(0):.  2017
  30. High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors
    Authors: C Chauvin, A Leruste, A Tauziede-E, M Andrianter, D Surdez, A Lescure, ZY Han, E Anthony, W Richer, S Baulande, M Bohec, S Zaidi, MM Aynaud, L Maillot, J Masliah-Pl, S Cairo, S Roman-Roma, O Delattre, E Del Nery, F Bourdeaut
    Cell Rep, 2017;21(7):1737-1745.  2017
  31. Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer
    Authors: C Li, B Singh, R Graves-Dea, H Ma, A Starchenko, WH Fry, Y Lu, Y Wang, G Bogatcheva, MP Khan, GL Milne, S Zhao, GD Ayers, N Li, H Hu, MK Washington, TJ Yeatman, OG McDonald, Q Liu, RJ Coffey
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.  2017
  32. Protein C receptor stimulates multiple signaling pathways in breast cancer cells
    Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
    J. Biol. Chem., 2017;0(0):.  2017
  33. Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis
    Authors: K Noh, LS Mangala, HD Han, N Zhang, S Pradeep, SY Wu, S Ma, E Mora, R Rupaimoole, D Jiang, Y Wen, MMK Shahzad, Y Lyons, M Cho, W Hu, AS Nagaraja, M Haemmerle, CSL Mak, X Chen, KM Gharpure, H Deng, W Xiong, CV Kingsley, J Liu, N Jennings, MJ Birrer, RR Bouchard, G Lopez-Bere, RL Coleman, Z An, AK Sood
    Cell Rep, 2017;21(10):2785-2795.  2017
  34. BCL6 promotes glioma and serves as a therapeutic target
    Authors: L Xu, Y Chen, M Dutra-Clar, A Mayakonda, M Hazawa, SE Savinoff, N Doan, JW Said, WH Yong, A Watkins, H Yang, LW Ding, YY Jiang, JW Tyner, J Ching, JP Kovalik, V Madan, SL Chan, M Müschen, JJ Breunig, DC Lin, HP Koeffler
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.  2017
  35. Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling
    Authors: HP Hsu, MD Lai, JC Lee, MC Yen, TY Weng, WC Chen, JH Fang, YL Chen
    Sci Rep, 2017;7(1):5823.  2017
  36. EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming
    Authors: R Adelaiye-O, J Budka, NP Damayanti, J Arrington, MW Ferris, CC Hsu, S Chintala, AR Orillion, KM Miles, L Shen, M Elbanna, E Ciamporcer, S Arisa, P Pettazzoni, GF Draetta, M Seshadri, BA Hancock, M Radovich, J Kota, M Buck, H Keilhack, BP McCarthy, SA Persohn, PR Territo, Y Zang, J Irudayaraj, AW Tao, P Hollenhors, R Pili
    Cancer Res., 2017;0(0):.  2017
  37. Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest
    Authors: K Oura, T Tadokoro, S Fujihara, A Morishita, T Chiyo, E Samukawa, Y Yamana, K Fujita, T Sakamoto, T Nomura, H Yoneyama, H Kobara, H Mori, H Iwama, K Okano, Y Suzuki, T Masaki
    Oncol. Rep., 2017;38(5):2825-2835.  2017
  38. MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutant lung cancer
    Authors: S Nanjo, S Arai, W Wang, S Takeuchi, T Yamada, A Hata, N Katakami, Y Okada, S Yano
    Mol. Cancer Ther, 2017;0(0):.  2017
  39. Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases
    Authors: G Cassinelli, E Favini, L Dal Bo, M Tortoreto, M De Maglie, G Dagrada, S Pilotti, F Zunino, N Zaffaroni, C Lanzi
    Oncotarget, 2016;7(30):47848-47863.  2016
  40. Activation of EGFR Bypass Signaling by TGF? Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells
    Authors: T Tani, H Yasuda, J Hamamoto, A Kuroda, D Arai, K Ishioka, K Ohgino, M Miyawaki, I Kawada, K Naoki, Y Hayashi, T Betsuyaku, K Soejima
    Mol. Cancer Ther., 2016;15(1):162-71.  2016
  41. Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway.
    Authors: Szymanska E, Skowronek A, Miaczynska M
    Cell Signal, 2016;28(1):160-71.  2016
  42. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
    Nat Commun, 2016;7(0):12038.  2016
  43. Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the Downregulation of Epidermal Growth Factor Receptor
    Authors: Maurizio Bifulco
    Int. J. Cancer, 2016;0(0):.  2016
  44. EphA2 is a functional receptor for the growth factor progranulin
    Authors: Thomas Neill
    J. Cell Biol, 2016;215(5):687-703.  2016
  45. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
    Authors: T Yamaguchi, C Lu, L Ida, K Yanagisawa, J Usukura, J Cheng, N Hotta, Y Shimada, H Isomura, M Suzuki, T Fujimoto, T Takahashi
    Nat Commun, 2016;7(0):10060.  2016
  46. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma
    Authors: M Huang, T Liu, P Ma, RA Mitteer, Z Zhang, HJ Kim, E Yeo, D Zhang, P Cai, C Li, L Zhang, B Zhao, L Roccogrand, DM O'Rourke, N Dahmane, Y Gong, C Koumenis, Y Fan
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  47. FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases
    Authors: Y Xu, K Wang, Q Yu
    Oncotarget, 2016;7(43):70080-70091.  2016
  48. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
    Authors: Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, Munoz-Antonia T, Qu X, Eschrich S, Uramoto H, Tanaka F, Nasarre P, Gemmill R, Roche J, Drabkin H, Haura E
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  49. Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15
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  50. A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors.
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  51. Artificial human Met agonists based on macrocycle scaffolds.
    Authors: Ito, Kenichir, Sakai, Katsuya, Suzuki, Yoshinor, Ozawa, Naoya, Hatta, Tomohisa, Natsume, Tohru, Matsumoto, Kunio, Suga, Hiroaki
    Nat Commun, 2015;6(0):6373.  2015
  52. Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.
    Authors: Zemskova M, Song J, Cen B, Cerda-Infante J, Montecinos V, Kraft A
    Cell Signal, 2015;27(1):135-46.  2015
  53. Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer.
    Authors: Song A, Kim T, Kim D, Kim S, Keam B, Lee S, Heo D
    Clin Cancer Res, 2015;21(10):2379-87.  2015
  54. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
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    PLoS ONE, 2015;10(8):e0134948.  2015
  55. LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation.
    Authors: Tworkoski K, Raab-Traub N
    J Virol, 2015;89(5):2590-602.  2015
  56. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.
    Authors: Wang, J, Mikse, O, Liao, R G, Li, Y, Tan, L, Janne, P A, Gray, N S, Wong, K-K, Hammerman, P S
    Oncogene, 2015;34(17):2167-77.  2015
  57. Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status.
    Authors: Broecker-Preuss M, Muller S, Britten M, Worm K, Kurt Werner S, Mann K, Fuhrer D
    BMC Cancer, 2015;15(0):184.  2015
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Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 10/29/2018

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 08/28/2018

The kit is excellent for p-RTK array in human cell lines. I recommended it to my colleague.


Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 10/20/2017