Kit Summary

A membrane-based antibody array for the parallel determination of the relative phosphorylation of human receptor tyrosine kinases. Validated for analyte detection in cell lysates.

Key Benefits

  • Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously
  • Requires no specialized equipment
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-RTK Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple receptors in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 
Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Anti-Phospho-Tyrosine-HRP Detection Antibody
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these RTKs in a single sample
ALK/CD246 EphB4 MuSK
Axl EphB6 PDGF R alpha
DDR1 ErbB2 PDGF R beta
DDR2 ErbB3 c-Ret
Dtk ErbB4 ROR1
EGF R FGF R1 ROR2
EphA1 FGF R2 alpha Ryk
EphA2 FGF R3 SCF R/c-kit
EphA3 FGF R4 Tie-1
EphA4 Flt-3/Flk-2 Tie-2
EphA5 HGF R/c-MET TrkA
EphA6 IGF-I R TrkB
EphA7 Insulin R/CD220 TrkC
EphA10 M-CSF R VEGF R1/Flt-1
EphB1 Mer VEGF R2/KDR
EphB2 MSP R/Ron VEGF R3/Flt-4
EphB3    
 

Assays for Analytes represented in the Proteome Profiler Human Phospho-RTK Array Kit

 
Analyte Quantikine® ELISA Kits DuoSet® ELISA Development System DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits
ALK/CD246          
Axl   DY154 DYC1643    
DDR1     DYC2396 DYC5859  
DDR2     DYC2538 DYC6170  
Dtk   DY859      
EGF R DEGFR0 DY231 DYC1854 DYC1095B  
EphA1     DYC638    
EphA2     DYC3035 DYC4056  
EphA3          
EphA4     DYC3038 DYC4057  
EphA5          
EphA6          
EphA7          
EphA10          
EphB1          
EphB2          
EphB3          
EphB4     DYC3038 DYC4057  
ErbB2   DY1129 DYC1129 DYC1768  
ErbB3   DY348 DYC234 DYC1769 KCB5677
ErbB4     DYC1133 DYC2115
ErbB6          
FGF R1       DYC5079  
FGF R2 alpha     DYC665 DYC684  
FGF R3     DYC766 DYC2719  
FGF R4     DYC685 DYC5516  
Flt-3/Flk     DYC912 DYC368  
HGF R/c-MET   DY358 DYC358 DYC2480  
IGF-I R   DY391 DYC305 DYC1770  
Insulin R/CD220     DYC1544 DYC2718  
M-CSF R   DY329 DYC329 DYC3268  
Mer   DY6488 DYC891 DYC2579  
MSP R/Ron     DYC691 DYC1947  
MuSK          
PDGF R alpha     DYC322 DYC2114  
Ret          
ROR1          
ROR2          
Ryk          
PDGF R beta     DYC385 DYC1767  
DYC3096  
SCF R/c-kit DSCR00 DY332 DYC332 DYC3527  
Tie-1   DY5907      
Tie-2 DTE200 DY5159   DCY2720  
TrkA     DYC175 DYC2578  
TrkB     DYC397 DYC688  
TrkC     DYC373    
VEGF R1/Flt-1 DVR100B DY321B   DYC4170  
VEGF R2/KDR DVR200 DY357 DYC1780 DYC1766  
VEGF R3/Flt-4   DY349 DYC3491 DYC2724  
 

Troubleshooting Guide

Data Examples
Figure 1.
View Larger Image

Figure 1. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment.

Figure 2.
View Larger Image

Figure 2. The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. MDA-MB-453 human breast cancer cells were treated with 100 ng/mL of rhNRG1-beta1/HRG1-beta1 (R&D Systems, Catalog # 396-HB) for 5 minutes. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor.

Preparation and Storage
  • Stability & Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: RTK Assay Kits
Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane proteins that act as receptors for growth factors, neurotrophic factors, and other extracellular signaling molecules. Upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail. This leads to the binding of protein substrates and/or the establishment docking sites for adaptor proteins involved in RTK-mediated signal transduction. RTKs have critical functions in several developmental processes including regulating cell survival, proliferation, and motility. When unregulated, they play prominent roles in cancer formation. R&D Systems offers several different multiplex assay formats that allow the user to assess the activity of many RTKs in a single sample. Available RTK multiplex kits include bead-based multiplex kits for the Luminex platform, membrane-based antibody arrays, and microplate-based antibody arrays.
  • Alternate Names:
    RTK Assay Kits
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

117 Citations: Showing 1 - 10

  1. Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications
    Authors: SS Yadav, J Li, JA Stockert, B Herzog, J O'Connor, L Garzon-Man, R Parsons, AK Tewari, KK Yadav
    Transl Oncol, 2017;10(3):357-366. 2017
  2. Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS
    Authors: E Saintas, L Abrahams, GT Ahmad, AM Ajakaiye, AS AlHumaidi, C Ashmore-Ha, I Clark, UK Dura, CN Fixmer, C Ike-Morris, M Mato Prado, D Mccullough, S Mishra, KM Schöler, H Timur, MD Williamson, M Alatsatian, B Bahsoun, E Blackburn, CE Hogwood, PE Lithgow, M Rowe, L Yiangou, F Rothweiler, J Cinatl, R Zehner, AJ Baines, MD Garrett, CW Gourlay, DK Griffin, WJ Gullick, E Hargreaves, MJ Howard, DR Lloyd, JS Rossman, CM Smales, AD Tsaousis, T von der Ha, MN Wass, M Michaelis
    PLoS ONE, 2017;12(2):e0172140. 2017
  3. Amplification of EGFR wild type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors
    Authors: S Nukaga, H Yasuda, K Tsuchihara, J Hamamoto, K Masuzawa, I Kawada, K Naoki, S Matsumoto, S Mimaki, S Ikemura, K Goto, T Betsuyaku, K Soejima
    Cancer Res, 2017;0(0):. 2017
  4. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017;0(0):. 2017
  5. MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutant lung cancer
    Authors: S Nanjo, S Arai, W Wang, S Takeuchi, T Yamada, A Hata, N Katakami, Y Okada, S Yano
    Mol. Cancer Ther, 2017;0(0):. 2017
  6. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma
    Authors: M Huang, T Liu, P Ma, RA Mitteer, Z Zhang, HJ Kim, E Yeo, D Zhang, P Cai, C Li, L Zhang, B Zhao, L Roccogrand, DM O'Rourke, N Dahmane, Y Gong, C Koumenis, Y Fan
    J Clin Invest, 2016;0(0):. 2016
  7. Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases
    Authors: G Cassinelli, E Favini, L Dal Bo, M Tortoreto, M De Maglie, G Dagrada, S Pilotti, F Zunino, N Zaffaroni, C Lanzi
    Oncotarget, 2016;7(30):47848-47863. 2016
  8. Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15
    PLoS ONE, 2016;11(5):e0155561. 2016
  9. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
    Authors: Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, Munoz-Antonia T, Qu X, Eschrich S, Uramoto H, Tanaka F, Nasarre P, Gemmill R, Roche J, Drabkin H, Haura E
    PLoS ONE, 2016;11(1):e0147344. 2016
  10. Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway.
    Authors: Szymanska E, Skowronek A, Miaczynska M
    Cell Signal, 2016;28(1):160-71. 2016
  11. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
    Nat Commun, 2016;7(0):12038. 2016
  12. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
    Authors: Laukkanen, Mikko O, Cammarota, Francesc, Esposito, Tiziana, Salvatore, Marco, Castellone, Maria D
    PLoS ONE, 2015;10(3):e0121441. 2015
  13. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
    Authors: Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama J
    PLoS ONE, 2015;10(8):e0134948. 2015
  14. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.
    Authors: Wang, J, Mikse, O, Liao, R G, Li, Y, Tan, L, Janne, P A, Gray, N S, Wong, K-K, Hammerman, P S
    Oncogene, 2015;34(17):2167-77. 2015
  15. Artificial human Met agonists based on macrocycle scaffolds.
    Authors: Ito, Kenichir, Sakai, Katsuya, Suzuki, Yoshinor, Ozawa, Naoya, Hatta, Tomohisa, Natsume, Tohru, Matsumoto, Kunio, Suga, Hiroaki
    Nat Commun, 2015;6(0):6373. 2015
  16. Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.
    Authors: Zemskova M, Song J, Cen B, Cerda-Infante J, Montecinos V, Kraft A
    Cell Signal, 2015;27(1):135-46. 2015
  17. Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors.
    Authors: Cohen N, Zeng S, Seifert A, Kim T, Sorenson E, Greer J, Beckman M, Santamaria-Barria J, Crawley M, Green B, Rossi F, Besmer P, Antonescu C, DeMatteo R
    Cancer Res, 2015;75(10):2061-70. 2015
  18. Biologically active LIL proteins built with minimal chemical diversity.
    Authors: Heim E, Marston J, Federman R, Edwards A, Karabadzhak A, Petti L, Engelman D, DiMaio D
    Proc Natl Acad Sci U S A, 2015;112(34):E4717-25. 2015
  19. A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors.
    Authors: Puzanov I, Lindsay C, Goff L, Sosman J, Gilbert J, Berlin J, Poondru S, Simantov R, Gedrich R, Stephens A, Chan E, Evans T
    Clin Cancer Res, 2015;21(4):701-11. 2015
  20. MITF Modulates Therapeutic Resistance through EGFR Signaling.
    Authors: Ji Z, Erin Chen Y, Kumar R, Taylor M, Jenny Njauw C, Miao B, Frederick D, Wargo J, Flaherty K, Jonsson G, Tsao H
    J Invest Dermatol, 2015;135(7):1863-72. 2015
  21. LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation.
    Authors: Tworkoski K, Raab-Traub N
    J Virol, 2015;89(5):2590-602. 2015
  22. Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status.
    Authors: Broecker-Preuss M, Muller S, Britten M, Worm K, Kurt Werner S, Mann K, Fuhrer D
    BMC Cancer, 2015;15(0):184. 2015
  23. Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways.
    Authors: Wu, Jia-Ru, Hu, Chi-Tan, You, Ren-In, Ma, Pei-Ling, Pan, Siou-Mei, Lee, Ming-Che, Wu, Wen-Shen
    PLoS ONE, 2015;10(1):e0114495. 2015
  24. Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer.
    Authors: Song A, Kim T, Kim D, Kim S, Keam B, Lee S, Heo D
    Clin Cancer Res, 2015;21(10):2379-87. 2015
  25. A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor alpha.
    Authors: Lei H, Kazlauskas A
    Mol Cell Biol, 2014;34(1):110-22. 2014
  26. Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma.
    Authors: Carlino M, Todd J, Gowrishankar K, Mijatov B, Pupo G, Fung C, Snoyman S, Hersey P, Long G, Kefford R, Rizos H
    Mol Oncol, 2014;8(3):544-54. 2014
  27. Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up.
    Authors: Ugurel S, Mentzel T, Utikal J, Helmbold P, Mohr P, Pfohler C, Schiller M, Hauschild A, Hein R, Kampgen E, Kellner I, Leverkus M, Becker J, Strobel P, Schadendorf D
    Clin Cancer Res, 2014;20(2):499-510. 2014
  28. Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.
    Authors: Shiono, Masatosh, Kobayashi, Toshiyuk, Takahashi, Riichi, Ueda, Masatsug, Ishioka, Chikashi, Hino, Okio
    Sci Rep, 2014;4(0):5927. 2014
  29. EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy.
    Authors: Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R
    Oncol Rep, 2014;31(1):480-7. 2014
  30. Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer.
    Authors: Montero J, Esparis-Ogando A, Re-Louhau M, Seoane S, Abad M, Calero R, Ocana A, Pandiella A
    Oncogene, 2014;33(2):148-56. 2014
  31. Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS.
    Authors: Outani, Hidetats, Tanaka, Takaaki, Wakamatsu, Toru, Imura, Yoshinor, Hamada, Kenichir, Araki, Nobuhito, Itoh, Kazuyuki, Yoshikawa, Hideki, Naka, Norifumi
    BMC Cancer, 2014;14(0):455. 2014
  32. Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma.
    Authors: Imura, Yoshinor, Yasui, Hirohiko, Outani, Hidetats, Wakamatsu, Toru, Hamada, Kenichir, Nakai, Takaaki, Yamada, Shutaro, Myoui, Akira, Araki, Nobuhito, Ueda, Takafumi, Itoh, Kazuyuki, Yoshikawa, Hideki, Naka, Norifumi
    Mol Cancer, 2014;13(0):185. 2014
  33. Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.
    Authors: Calero R, Morchon E, Johnsen J, Serrano R
    PLoS ONE, 2014;9(4):e95628. 2014
  34. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
    Authors: Sakanyan V, Angelini M, Le Bechec M, Lecocq M, Benaiteau F, Rousseau B, Gyulkhandanyan A, Gyulkhandanyan L, Loge C, Reiter E, Roussakis C, Fleury F
    Sci Rep, 2014;4(0):3977. 2014
  35. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines.
    Authors: Vultur A, Villanueva J, Krepler C, Rajan G, Chen Q, Xiao M, Li L, Gimotty P, Wilson M, Hayden J, Keeney F, Nathanson K, Herlyn M
    Oncogene, 2014;33(14):1850-61. 2014
  36. Improvement of human keratinocyte migration by a redox active bioelectric dressing.
    Authors: Banerjee J, Das Ghatak P, Roy S, Khanna S, Sequin E, Bellman K, Dickinson B, Suri P, Subramaniam V, Chang C, Sen C
    PLoS ONE, 2014;9(3):e89239. 2014
  37. An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.
    Authors: Li L, Chakraborty S, Yang C, Hatanpaa K, Cipher D, Puliyappadamba V, Rehman A, Jiwani A, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle S, Kesari S, Boothman D, Habib A
    Oncogene, 2014;33(33):4253-64. 2014
  38. Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.
    Authors: Okon I, Coughlan K, Zou M
    J Biol Chem, 2014;289(3):1639-48. 2014
  39. Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin.
    Authors: de-Freitas-Junior J, Carvalho S, Dias A, Oliveira P, Cabral J, Seruca R, Oliveira C, Morgado-Diaz J, Reis C, Pinho S
    PLoS ONE, 2013;8(11):e81579. 2013
  40. Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.
    Authors: Kwon, Heung Su, Johnson, Thomas V, Joe, Myung Ku, Abu-Asab, Mones, Zhang, Jun, Chan, Chi Chao, Tomarev, Stanisla
    J Biol Chem, 2013;288(37):26357-71. 2013
  41. Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.
    Authors: Lee H, Bennett A
    Mol Cell Biol, 2013;33(7):1430-41. 2013
  42. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
    Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
    PLoS ONE, 2013;8(12):e83687. 2013
  43. Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein.
    Authors: Krzyzaniak M, Zumstein M, Gerez J, Picotti P, Helenius A
    PLoS Pathog, 2013;9(4):e1003309. 2013
  44. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
    Authors: Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, Titz B, Huang J, Pienta K, Graeber T, Witte O
    Proc Natl Acad Sci U S A, 2013;110(49):E4762-9. 2013
  45. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
    Authors: Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Paul A J, Heasley, Lynn E, Tan, Aik-Choo, Camidge, D Ross, Varella-Garcia, Marileil, Doebele, Robert C
    PLoS ONE, 2013;8(12):e82236. 2013
  46. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
    Authors: Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy C, Wetzel K, George E, Popa M, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither L, Bentires-Alj M
    Proc Natl Acad Sci U S A, 2013;110(11):E1026-34. 2013
  47. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma.
    Authors: Ho A, Vasudeva S, Lae M, Saito T, Barbashina V, Antonescu C, Ladanyi M, Schwartz G
    Cancer Res, 2012;72(17):4515-25. 2012
  48. Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.
    Authors: Oliveras-Ferraros C, Cufi S, Queralt B, Vazquez-Martin A, Martin-Castillo B, de Llorens R, Bosch-Barrera J, Brunet J, Menendez JA
    Br. J. Cancer, 2012;106(8):1406-14. 2012
  49. Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition.
    Authors: Gowrishankar K, Snoyman S, Pupo GM, Becker TM, Kefford RF, Rizos H
    J. Invest. Dermatol., 2012;132(7):1850-9. 2012
  50. Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors.
    Authors: Bai Y, Li J, Fang B, Edwards A, Zhang G, Bui M, Eschrich S, Altiok S, Koomen J, Haura E
    Cancer Res, 2012;72(10):2501-11. 2012
  51. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
    Clin. Cancer Res., 2012;18(17):4570-9. 2012
  52. Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.
    Authors: Purushothaman, Anurag, Babitz, Stephen, Sanderson, Ralph D
    J Biol Chem, 2012;287(49):41288-96. 2012
  53. Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.
    Authors: Ball SG, Shuttleworth A, Kielty CM
    Stem Cells, 2012;30(3):548-60. 2012
  54. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.
    Authors: Duncan J, Whittle M, Nakamura K, Abell A, Midland A, Zawistowski J, Johnson N, Granger D, Jordan N, Darr D, Usary J, Kuan P, Smalley D, Major B, He X, Hoadley K, Zhou B, Sharpless N, Perou C, Kim W, Gomez S, Chen X, Jin J, Frye S, Earp H, Graves L, Johnson G
    Cell, 2012;149(2):307-21. 2012
  55. Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors.
    Authors: Chakrabarty A, Sanchez V, Kuba MG, Rinehart C, Arteaga CL
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(8):2718-23. 2012
  56. Prostaglandin E(2) induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway.
    J. Immunol., 2012;189(5):2563-73. 2012
  57. Fibroblast Growth Factor Receptor 3 (FGFR3) Associated with the CD20 Antigen Regulates the Rituximab-induced Proliferation Inhibition in B-cell Lymphoma Cells.
    Authors: Kotani N, Ishiura Y, Yamashita R, Ohnishi T, Honke K
    J Biol Chem, 2012;287(44):37109-18. 2012
  58. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.
    Authors: Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M
    Oncogene, 2012;31(26):3136-47. 2012
  59. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
    Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory
    PLoS ONE, 2012;7(10):e44372. 2012
  60. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
    Authors: Lin, Shih-Pei, Lee, Yi-Ting, Wang, Jir-You, Miller, Stephani, Chiou, Shih-Hwa, Hung, Mien-Chi, Hung, Shih-Chi
    PLoS ONE, 2012;7(11):e49605. 2012
  61. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation.
    Authors: Jiao Y, Ou W, Meng F
    Mol. Cancer, 2011;10(0):125. 2011
  62. Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells.
    Authors: Ding VM, Boersema PJ, Foong LY
    PLoS ONE, 2011;6(3):e17538. 2011
  63. Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
    Authors: Tanabe H, Kuribayashi K, Tsuji N
    Int. J. Oncol., 2011;39(1):33-40. 2011
  64. 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer.
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