Proteome Profiler Human Phospho-RTK Array Kit

Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Catalog # Availability Size / Price Qty
ARY001B
Product Details
Citations (178)
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Proteome Profiler Human Phospho-RTK Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative phosphorylation of human receptor tyrosine kinases. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously
  • Requires no specialized equipment
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-RTK Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple receptors in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 
Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Anti-Phospho-Tyrosine-HRP Detection Antibody
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these RTKs in a single sample
ALK/CD246 EphB4 MuSK
Axl EphB6 PDGF R alpha
DDR1 ErbB2 PDGF R beta
DDR2 ErbB3 c-Ret
Dtk ErbB4 ROR1
EGF R FGF R1 ROR2
EphA1 FGF R2 alpha Ryk
EphA2 FGF R3 SCF R/c-kit
EphA3 FGF R4 Tie-1
EphA4 Flt-3/Flk-2 Tie-2
EphA5 HGF R/c-MET TrkA
EphA6 IGF-I R TrkB
EphA7 Insulin R/CD220 TrkC
EphA10 M-CSF R VEGF R1/Flt-1
EphB1 Mer VEGF R2/KDR
EphB2 MSP R/Ron VEGF R3/Flt-4
EphB3    
 

Assays for Analytes represented in the Proteome Profiler Human Phospho-RTK Array Kit

 
Analyte Quantikine® ELISA Kits DuoSet® ELISA Development System DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits
ALK/CD246          
Axl   DY154 DYC1643    
DDR1     DYC2396 DYC5859  
DDR2     DYC2538 DYC6170  
Dtk   DY859      
EGF R DEGFR0 DY231 DYC1854 DYC1095B  
EphA1     DYC638    
EphA2     DYC3035 DYC4056  
EphA3          
EphA4     DYC3038 DYC4057  
EphA5          
EphA6          
EphA7          
EphA10          
EphB1          
EphB2          
EphB3          
EphB4     DYC3038 DYC4057  
ErbB2   DY1129 DYC1129 DYC1768  
ErbB3   DY348 DYC234 DYC1769 KCB5677
ErbB4     DYC1133 DYC2115
ErbB6          
FGF R1       DYC5079  
FGF R2 alpha     DYC665 DYC684  
FGF R3     DYC766 DYC2719  
FGF R4     DYC685 DYC5516  
Flt-3/Flk     DYC912 DYC368  
HGF R/c-MET   DY358 DYC358 DYC2480  
IGF-I R   DY391 DYC305 DYC1770  
Insulin R/CD220     DYC1544 DYC2718  
M-CSF R   DY329 DYC329 DYC3268  
Mer   DY6488 DYC891 DYC2579  
MSP R/Ron     DYC691 DYC1947  
MuSK          
PDGF R alpha     DYC322 DYC2114  
Ret          
ROR1          
ROR2          
Ryk          
PDGF R beta     DYC385 DYC1767  
DYC3096  
SCF R/c-kit DSCR00 DY332 DYC332 DYC3527  
Tie-1   DY5907      
Tie-2 DTE200 DY5159   DCY2720  
TrkA     DYC175 DYC2578  
TrkB     DYC397 DYC688  
TrkC     DYC373    
VEGF R1/Flt-1 DVR100B DY321B   DYC4170  
VEGF R2/KDR DVR200 DY357 DYC1780 DYC1766  
VEGF R3/Flt-4   DY349 DYC3491 DYC2724  
 
Data Examples
Figure 1. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes.
View Larger Image

Figure 1. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment.

Figure 2. The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition.
View Larger Image

Figure 2. The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. MDA-MB-453 human breast cancer cells were treated with 100 ng/mL of rhNRG1-beta1/HRG1-beta1 (R&D Systems, Catalog # 396-HB) for 5 minutes. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor.

Product Datasheets

Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: RTK Assay Kits

Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane proteins that act as receptors for growth factors, neurotrophic factors, and other extracellular signaling molecules. Upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail. This leads to the binding of protein substrates and/or the establishment docking sites for adaptor proteins involved in RTK-mediated signal transduction. RTKs have critical functions in several developmental processes including regulating cell survival, proliferation, and motility. When unregulated, they play prominent roles in cancer formation. R&D Systems offers several different multiplex assay formats that allow the user to assess the activity of many RTKs in a single sample. Available RTK multiplex kits include bead-based multiplex kits for the Luminex platform, membrane-based antibody arrays, and microplate-based antibody arrays.

Alternate Names
RTK Assay Kits

Citations for Proteome Profiler Human Phospho-RTK Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

178 Citations: Showing 1 - 10
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  1. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
    Authors: TA Ahmed, C Adamopoulo, Z Karoulia, X Wu, R Sachidanan, SA Aaronson, PI Poulikakos
    Cell Rep, 2019;26(1):65-78.e5.  2019
  2. Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
    Authors: LM van der Wa, J Laoukili, JMJ Jongen, DA Raats, IHM Borel Rink, O Kranenburg
    Sci Rep, 2019;9(1):819.  2019
  3. Modeling Patient-Derived Glioblastoma with Cerebral Organoids
    Authors: A Linkous, D Balamatsia, M Snuderl, L Edwards, K Miyaguchi, T Milner, B Reich, L Cohen-Goul, A Storaska, Y Nakayama, E Schenkein, R Singhania, S Cirigliano, T Magdeldin, Y Lin, G Nanjangud, K Chadalavad, D Pisapia, C Liston, HA Fine
    Cell Rep, 2019;26(12):3203-3211.e5.  2019
  4. Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer
    Authors: R Graves-Dea, G Bogatcheva, S Rehman, Y Lu, JN Higginboth, B Singh
    Oncotarget, 2019;10(13):1320-1333.  2019
  5. A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers
    Authors: S Rao, G Du, M Hafner, K Subramania, PK Sorger, NS Gray
    J. Biol. Chem., 2019;0(0):.  2019
  6. Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status
    Authors: K Fukuda, S Takeuchi, S Arai, R Katayama, S Nanjo, A Tanimoto, A Nishiyama, T Nakagawa, H Taniguchi, T Suzuki, T Yamada, H Nishihara, H Ninomiya, Y Ishikawa, S Baba, K Takeuchi, A Horiike, N Yanagitani, M Nishio, S Yano
    Cancer Res., 2019;0(0):.  2019
  7. Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis
    Authors: L He, L Gao, C Shay, L Lang, F Lv, Y Teng
    J. Exp. Clin. Cancer Res., 2019;38(1):84.  2019
  8. Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis
    Authors: M Sramek, J Neradil, P Macigova, P Mudry, K Polaskova, O Slaby, H Noskova, J Sterba, R Veselska
    Int J Mol Sci, 2018;19(9):.  2018
  9. Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo
    Authors: S Boichuk, A Galembikov, P Dunaev, E Micheeva, E Valeeva, M Novikova, N Khromova, P Kopnin
    Molecules, 2018;23(10):.  2018
  10. HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation
    Authors: S Sun, Y Zhang, J Zheng, B Duan, J Cui, Y Chen, W Deng, B Ye, L Liu, Y Chen, J Du, L Gu
    Cell Death Dis, 2018;9(9):929.  2018
  11. Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-Tissue Sarcoma: Potential Therapeutic implication for Synovial Sarcoma
    Authors: PP Patwardhan, E Musi, GK Schwartz
    Mol. Cancer Ther., 2018;0(0):.  2018
  12. Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
    Authors: F Mao, C Holmlund, M Faraz, W Wang, T Bergenheim, S Kvarnbrink, M Johansson, R Henriksson, H Hedman
    Oncogenesis, 2018;7(2):13.  2018
  13. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038.  2018
  14. LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals
    Authors: SN Jung, HS Lim, L Liu, JW Chang, YC Lim, KS Rha, BS Koo
    Sci Rep, 2018;8(1):2718.  2018
  15. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018;47(5):1751-1768.  2018
  16. Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation
    Authors: AR Virzì, A Gentile, S Benvenuti, PM Comoglio
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.  2018
  17. BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines
    Authors: R Herr, S Halbach, M Heizmann, H Busch, M Boerries, T Brummer
    Oncogene, 2018;0(0):.  2018
  18. Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
    Authors: B Haas, V Klinger, C Keksel, V Bonigut, D Kiefer, J Caspers, J Walther, M Wos-Magang, S Weickhardt, G Röhn, M Timmer, R Frötschl, N Eckstein
    Cancer Cell Int., 2018;18(0):69.  2018
  19. MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib
    Authors: K Ninomiya, K Ohashi, G Makimoto, S Tomida, H Higo, H Kayatani, T Ninomiya, T Kubo, E Ichihara, K Hotta, M Tabata, Y Maeda, K Kiura
    Sci Rep, 2018;8(1):1955.  2018
  20. A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
    Authors: AH Daneshmane, M Hojjat-Far, A Ghaderi, A Moshfegh, L Hansson, J Schultz, J Vågberg, S Byström, E Olsson, T Olin, A Österborg, H Mellstedt
    PLoS ONE, 2018;13(6):e0198038.  2018
  21. Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target
    Authors: E Yángüez, A Hunziker, MP Dobay, S Yildiz, S Schading, E Elshina, U Karakus, P Gehrig, J Grossmann, R Dijkman, M Schmolke, S Stertz
    Nat Commun, 2018;9(1):3679.  2018
  22. Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
    Authors: J Heliste, A Jokilammi, I Paatero, D Chakrobort, C Stark, T Savunen, M Laaksonen, K Elenius
    BMC Cardiovasc Disord, 2018;18(1):196.  2018
  23. BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC
    Authors: B Leonard, TM Brand, RA O'Keefe, E Lee, Y Zang, JD Kemmer, H Li, JR Grandis, NE Bhola
    Cancer Res., 2018;0(0):.  2018
  24. TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling
    Authors: STK Sin, Y Li, M Liu, S Ma, XY Guan
    Gynecol. Oncol., 2018;0(0):.  2018
  25. The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
    Authors: X Wang, J Ai, H Liu, X Peng, H Chen, Y Chen, Y Su, A Shen, X Huang, J Ding, M Geng
    Mol. Cancer Ther., 2018;0(0):.  2018
  26. Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
    Authors: SA Greenall, J Donoghue, TG Johns, TE Adams
    Transl Oncol, 2018;11(4):971-978.  2018
  27. Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers
    Authors: H Kotani, Y Adachi, H Kitai, S Tomida, H Bando, AC Faber, T Yoshino, DC Voon, S Yano, H Ebi
    Oncogene, 2018;0(0):.  2018
  28. Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma
    Authors: U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar
    Oncotarget, 2018;9(77):34582-34594.  2018
  29. Identification of FDA-approved oncology drugs with selective potency in high-risk childhood ependymoma
    Authors: AM Donson, V Amani, EA Warner, AM Griesinger, DA Witt, JM Mulcahy Le, LM Hoffman, TC Hankinson, MH Handler, R Vibhakar, K Dorris, NK Foreman
    Mol. Cancer Ther., 2018;0(0):.  2018
  30. Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3
    Authors: WJ Jang, SK Jung, TTL Vo, CH Jeong
    J. Cell. Mol. Med., 2018;0(0):.  2018
  31. Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
    Authors: SH Choi, AR Kim, JK Nam, JM Kim, JY Kim, HR Seo, HJ Lee, J Cho, YJ Lee
    Nat Commun, 2018;9(1):5108.  2018
  32. Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway
    Authors: ST Chen, TC Kuo, YY Liao, MC Lin, YW Tien, MC Huang
    Oncogene, 2018;0(0):.  2018
  33. Amplification of EGFR wild type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors
    Authors: S Nukaga, H Yasuda, K Tsuchihara, J Hamamoto, K Masuzawa, I Kawada, K Naoki, S Matsumoto, S Mimaki, S Ikemura, K Goto, T Betsuyaku, K Soejima
    Cancer Res, 2017;0(0):.  2017
  34. Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS
    Authors: E Saintas, L Abrahams, GT Ahmad, AM Ajakaiye, AS AlHumaidi, C Ashmore-Ha, I Clark, UK Dura, CN Fixmer, C Ike-Morris, M Mato Prado, D Mccullough, S Mishra, KM Schöler, H Timur, MD Williamson, M Alatsatian, B Bahsoun, E Blackburn, CE Hogwood, PE Lithgow, M Rowe, L Yiangou, F Rothweiler, J Cinatl, R Zehner, AJ Baines, MD Garrett, CW Gourlay, DK Griffin, WJ Gullick, E Hargreaves, MJ Howard, DR Lloyd, JS Rossman, CM Smales, AD Tsaousis, T von der Ha, MN Wass, M Michaelis
    PLoS ONE, 2017;12(2):e0172140.  2017
  35. BCL6 promotes glioma and serves as a therapeutic target
    Authors: L Xu, Y Chen, M Dutra-Clar, A Mayakonda, M Hazawa, SE Savinoff, N Doan, JW Said, WH Yong, A Watkins, H Yang, LW Ding, YY Jiang, JW Tyner, J Ching, JP Kovalik, V Madan, SL Chan, M Müschen, JJ Breunig, DC Lin, HP Koeffler
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.  2017
  36. Altered Met Receptor Phosphorylation and LRP1 Mediated Uptake in Cells Lacking Carbohydrate-Dependent Lysosomal Targeting
    Authors: M Aarnio-Pet, P Zhao, SH Yu, C Christian, H Flanagan-S, L Wells, R Steet
    J. Biol. Chem., 2017;0(0):.  2017
  37. High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors
    Authors: C Chauvin, A Leruste, A Tauziede-E, M Andrianter, D Surdez, A Lescure, ZY Han, E Anthony, W Richer, S Baulande, M Bohec, S Zaidi, MM Aynaud, L Maillot, J Masliah-Pl, S Cairo, S Roman-Roma, O Delattre, E Del Nery, F Bourdeaut
    Cell Rep, 2017;21(7):1737-1745.  2017
  38. Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
    Authors: K Miyata, A Takemoto, S Okumura, M Nishio, N Fujita
    Sci Rep, 2017;7(1):4059.  2017
  39. Insulin-like Growth Factor-1 signalling is essential for Mitochondrial Biogenesis and Mitophagy in cancer cells
    Authors: A Lyons, M Coleman, S Riis, C Favre, CH O'Flanagan, AV Zhdanov, DB Papkovsky, SD Hursting, R O'Connor
    J. Biol. Chem., 2017;0(0):.  2017
  40. Mechanisms of primary drug resistance in FGFR1 amplified lung cancer
    Authors: F Malchers, MS Ercanoglu, D Schütte, R Castiglion, V Tischler, S Michels, I Dahmen, J Brägelmann, R Menon, JM Heuckmann, J George, S Ansén, ML Sos, A Soltermann, M Peifer, J Wolf, R Büttner, RK Thomas
    Clin. Cancer Res., 2017;0(0):.  2017
  41. Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer
    Authors: C Li, B Singh, R Graves-Dea, H Ma, A Starchenko, WH Fry, Y Lu, Y Wang, G Bogatcheva, MP Khan, GL Milne, S Zhao, GD Ayers, N Li, H Hu, MK Washington, TJ Yeatman, OG McDonald, Q Liu, RJ Coffey
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.  2017
  42. Dual�Targeting�of�Insulin�Receptor�and�KIT�in�Imatinib-Resistant�Gastrointestinal�Stromal�Tumors
    Authors: W Chen, Y Kuang, HB Qiu, Z Cao, Y Tu, Q Sheng, G Eilers, Q He, HL Li, M Zhu, Y Wang, R Zhang, Y Wu, F Meng, JA Fletcher, WB Ou
    Cancer Res., 2017;0(0):.  2017
  43. Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol
    Authors: HE Pearson, M Iida, RA Orbuch, NK McDaniel, KP Nickel, RJ Kimple, J Arbiser, DL Wheeler
    Mol. Cancer Ther., 2017;0(0):.  2017
  44. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017;0(0):.  2017
  45. Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis
    Authors: K Noh, LS Mangala, HD Han, N Zhang, S Pradeep, SY Wu, S Ma, E Mora, R Rupaimoole, D Jiang, Y Wen, MMK Shahzad, Y Lyons, M Cho, W Hu, AS Nagaraja, M Haemmerle, CSL Mak, X Chen, KM Gharpure, H Deng, W Xiong, CV Kingsley, J Liu, N Jennings, MJ Birrer, RR Bouchard, G Lopez-Bere, RL Coleman, Z An, AK Sood
    Cell Rep, 2017;21(10):2785-2795.  2017
  46. In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines
    Authors: L Klameth, B Rath, G Hamilton
    J Cancer, 2017;8(10):1733-1743.  2017
  47. Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling
    Authors: HP Hsu, MD Lai, JC Lee, MC Yen, TY Weng, WC Chen, JH Fang, YL Chen
    Sci Rep, 2017;7(1):5823.  2017
  48. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
    Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
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  49. mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism
    Authors: A Lampada, J O'Prey, G Szabadkai, KM Ryan, D Hochhauser, P Salomoni
    Cell Death Differ., 2017;0(0):.  2017
  50. Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest
    Authors: K Oura, T Tadokoro, S Fujihara, A Morishita, T Chiyo, E Samukawa, Y Yamana, K Fujita, T Sakamoto, T Nomura, H Yoneyama, H Kobara, H Mori, H Iwama, K Okano, Y Suzuki, T Masaki
    Oncol. Rep., 2017;38(5):2825-2835.  2017
  51. MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutant lung cancer
    Authors: S Nanjo, S Arai, W Wang, S Takeuchi, T Yamada, A Hata, N Katakami, Y Okada, S Yano
    Mol. Cancer Ther, 2017;0(0):.  2017
  52. Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
    Authors: R Mansouri, Y Jouan, E Hay, C Blin-Wakka, M Frain, A Ostertag, C Le Henaff, C Marty, V Geoffroy, PJ Marie, M Cohen-Sola, D Modrowski
    Cell Death Dis, 2017;8(6):e2902.  2017
  53. Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications
    Authors: SS Yadav, J Li, JA Stockert, B Herzog, J O'Connor, L Garzon-Man, R Parsons, AK Tewari, KK Yadav
    Transl Oncol, 2017;10(3):357-366.  2017
  54. EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming
    Authors: R Adelaiye-O, J Budka, NP Damayanti, J Arrington, MW Ferris, CC Hsu, S Chintala, AR Orillion, KM Miles, L Shen, M Elbanna, E Ciamporcer, S Arisa, P Pettazzoni, GF Draetta, M Seshadri, BA Hancock, M Radovich, J Kota, M Buck, H Keilhack, BP McCarthy, SA Persohn, PR Territo, Y Zang, J Irudayaraj, AW Tao, P Hollenhors, R Pili
    Cancer Res., 2017;0(0):.  2017
  55. Protein C receptor stimulates multiple signaling pathways in breast cancer cells
    Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
    J. Biol. Chem., 2017;0(0):.  2017
  56. Piperlongumine downregulates the expression of HER family in breast cancer cells
    Authors: HO Jin, JA Park, HA Kim, YH Chang, YJ Hong, IC Park, JK Lee
    Biochem. Biophys. Res. Commun., 2017;0(0):.  2017
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Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 03/13/2019

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 10/29/2018

Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 08/28/2018

The kit is excellent for p-RTK array in human cell lines. I recommended it to my colleague.


Proteome Profiler Human Phospho-RTK Array Kit
By Anonymous on 10/20/2017