Mouse PDGF R beta Antibody

Catalog # Availability Size / Price Qty
AF1042
AF1042-SP

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Detection of Rat and Mouse PDGF R beta  by Western Blot.
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Product Details
Citations (58)
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Mouse PDGF R beta Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse PDGF R beta in direct ELISAs and Western blots. In direct ELISAs, this antibody shows approximately 35% cross-reactivity with recombinant human PDGF R beta.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse PDGF R beta
Leu32-Lys530
Accession # P05622
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.25 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Rat and Mouse PDGF R beta  antibody by Western Blot. View Larger

Detection of Rat and Mouse PDGF R beta by Western Blot. Western blot shows lysates of rat spinal cord tissue, rat brain tissue, and mouse brain tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1042) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for PDGF R beta at approximately 190 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry PDGF R beta  antibody in Mouse Embryonic Spinal Cord by Immunohistochemistry (IHC-Fr). View Larger

PDGF R beta in Mouse Embryonic Spinal Cord. PDGF R beta was detected in immersion fixed frozen sections of mouse embryo spinal cord using 5 µg/mL Goat Anti-Mouse PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1042) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Immunohistochemistry Detection of Mouse PDGF R beta by Immunohistochemistry View Larger

Detection of Mouse PDGF R beta by Immunohistochemistry Expression of sFlt1 in pericytes at the angiogenic front. a Maximum intensity projections of confocal images from P6 retinas of the Hey1-GFP transgenic reporter mouse model stained for GFP (green), PDGFR beta + (white) and IB4 (red). Images of the first row show enrichment of Hey1-GFP+, PDGFR beta + perivascular cells in the angiogenic front in comparison to mural cells covering the remodeling central plexus around veins (middle row) and arteries (bottom row). Note strong expression of Hey1-GFP reporter in arterial ECs (bottom row). Scale bar, 50 µm. b, Quantitation of Pdgfrb expression by qPCR in P6 PDGFR beta + retinal pericytes sorted based on GFP expression in comparison to whole-retina single-cell suspension (input). Note significant enrichment of Pdgfrb in both (GFP+ and GFP−) pericyte fractions and higher expression in the Hey1-GFP+ subset. Error bars, s.e.m. p-values, Kruskal–Wallis and Dunn’s multiple comparison test. NS, not statistically significant. c Quantitation of sFlt1 expression by qPCR in sorted P6 retinal pericytes in comparison to whole-retina single-cell suspension (input). Note significant enrichment of sFlt1 expression in Hey1-GFP+ pericytes in comparison to input and GFP- pericytes. Error bars, s.e.m. p-values, one-way ANOVA and Tukey’s multiple comparison test. NS, not statistically significant Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29146905), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse PDGF R beta by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse PDGF R beta by Immunocytochemistry/Immunofluorescence VCAM1 is involved in the regulation of proliferation and morphological changes in oligodendrocytes.(a) Tissue lysates from 7-day-old NG2-Cre-driven VCAM1 conditional knockout (VCAM1fl/fl; Ng2-Cre) or control (Ctrl) mouse spinal cords or 11-day-old whole brains were immunoblotted with an antibody against MBP, CNPase, VCAM1 or actin. Data are representative of three experiments. (b–d) Antibodies against Ki67 (green) and Olig2 (red) were used for co-staining in 2-day-old spinal cord cross sections. Data are representative. The scale bars indicate 200 μm. The number of Olig2+ cells per one square millimetre was counted. Data were evaluated using Student’s t-test (**P=0.000528; n=19 slices of two independent experiments). The percentage of Ki67+ cells among the Olig2+ cells is shown. Data were evaluated using Student’s t-test (**P=0.00807; n=6 slices of two independent experiments). (e) Antibodies against Ki67 and NG2 were used for co-staining in 2-day-old spinal cord. The percentage of Ki67+ cells among the NG2+ cells per one square millimetre is shown. Data were evaluated using Student’s t-test (*P=0.0275; n=6 slices of two independent experiments). (f–h) Knock-down efficiencies of shRNAs were confirmed by immunoblotting. Data are representative of three experiments. Oligodendrocytes were transfected with VCAM1 shRNA or control, co-cultured with neurons for 2 days, and co-stained with antibodies against NF (green) and NG2 (red). Magnified images of the dotted boxes (i, attached; ii, aligned) are shown below. Data are representative. Scale bar, 100 μm. The percentage of NG2+ cells whose process tips or cell bodies were attached to axons or aligned along axons is shown. Data were evaluated using Student’s t-test (**P=0.00109 (attached cells) or P=0.00982 (aligned cells); n=6 areas of three experiments). (i,k) Oligodendrocytes were cultured on dishes coated with or without recombinant alpha 4 beta 1 integrin in a growth medium containing PDGF and bFGF. Cells were co-stained with an anti-MBP antibody (red) and DAPI (blue) (a) or an anti-PDGFR alpha antibody (green) (b). Data are representative. Scale bar, 100 μm. The percentage of MBP+ cells is shown. Data were evaluated using Student’s t-test (**P=1.14E−10; n=6 areas of two independent experiments). (j,l) Oligodendrocytes transfected with VCAM1#1 or control shRNA were cultured on recombinant alpha 4 beta 1 integrin-coated dishes in the differentiation medium and co-stained with an anti-MBP antibody (red) and DAPI (blue). Data are representative. Scale bar, 100 μm. The percentage of MBP+ cells is shown. Data were evaluated using Student’s t-test (**P=1.82E−21; n=6 areas of two independent experiments). (m–o) Antibodies against Ki67 (green) and O4 (red) were used for co-staining in 7-day-old spinal cord. DAPI staining is also shown. Data are representative. Scale bar, 100 μm. The number of O4+ cells was counted. Data were evaluated using Student’s t-test (**P=5.87E−05 (P7) or P=5.87E−06 (P14); n=12 slices of two independent experiments). The percentage of Ki67− or Ki67+ cells among the O4+ cells is shown. Data were evaluated using Student’s t-test (**P=0.00344 (P7, Ki67−), 0.00344 (P7, Ki67+) or 0.000580 (P14, Ki67+) *P=0.0494 (P14, Ki67−); n=12 slices of two independent experiments). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/27876794), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse PDGF R beta by Immunohistochemistry View Larger

Detection of Mouse PDGF R beta by Immunohistochemistry Vascular alterations after intraocular VEGF-A injection. a Morphology of IB4-stained P6 wild-type retinal vessels at 4 h after administration of human VEGF-A165 (0.5 µl at a concentration of 5 μg μl−1). Note blunt appearance of the vessel front after VEGF-A injection but not for vehicle (PBS) control. Scale bar, 200 µm. b Quantitation of sprouts and filopodia at the front of the P6 vessel plexus after injection of VEGF-A165 or vehicle control. Error bars, s.e.m. p-values, Student’s t-test. c PDGFR beta + (green) pericytes are unaffected by short-term VEGF-A administration, whereas VEGFR2 immunosignals (white) are increased in IB4+ (red) ECs (arrowheads). Images shown correspond to insets in a. Scale bar, 100 µm. d Quantitation of VEGFR2 immunosignals intensity in the peripheral plexus of P6 retinas after injection of VEGF-A165 or vehicle control. Error bars, s.e.m. p-values, Student’s t-test. e Confocal images showing increased Esm1 immunostaining (white) in IB4+ (red) ECs in the peripheral plexus (arrowheads) after VEGF-A injection in P6 pups. Scale bar, 200 µm. f VEGF-A165 injection-mediated increase of Esm1 immunosignals (normalized to IB4+ EC area) in the peripheral capillary plexus but not at the edge of the angiogenic front in comparison to PBS-injected controls at P6. Error bars, s.e.m. p-values, Student’s t-test. NS, not statistically significant. g Short-term VEGF-A165 administration leads to clustering of Erg1+ (green) and IB4+ (red) ECs, as indicated, in thick sprout-like structures of P6 retinas. Panels in the center and on the right (scale bar, 20 µm) show higher magnification of the insets on the left (scale bar, 100 µm). Dashed lines in panels on the right outline IB4+ vessels. h Quantitation of EC density in the leading front vessel and emerging sprouts of the P6 angiogenic front after injection of VEGF-A165 or vehicle control. Error bars, s.e.m. p-values, Student’s t-test Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29146905), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PDGF R beta

The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and a heterodimer (PDGF-AB) (1, 2). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptors (PDGF R alpha and R beta ). Whereas alpha / alpha homo-dimerization is induced by PDGF-AA, -BB, -CC, and -AB, alpha / beta hetero-dimerization is induced by PDGF-AB, -BB, -CC, and -DD, and beta / beta homo-dimerization is induced only by PDGF-BB, and -DD (1 - 4). Both PDGF R alpha and R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3-ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-induced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the alpha and beta  receptors. Others have only the alpha receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets and megakaryocytes) or only the beta  receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells and macrophages). A soluble PDGF R alpha has been detected in normal human plasma and serum as well as in the conditioned medium of the human osteosarcoma cell line MG-63 (5). Both the recombinant mouse and human soluble PDGF R alpha bind PDGF with high affinity and are potent PDGF antagonists.

References
  1. Betshotz, C. et al. (2001) BioEssays 23:494.
  2. Ostman, A. and A.H. Heldin (2001) Advances in Cancer Research 80:1.
  3. Gilbertson, D. et al. (2001) J. Biol. Chem. 276:27406.
  4. LaRochells, W.J. et al. (2001) Nature Cell Biol. 3:517.
  5. Tiesman, J. and C.E. Hart (1993) J. Biol. Chem. 5:9621.
Long Name
Platelet-derived Growth Factor Receptor beta
Entrez Gene IDs
5159 (Human); 18596 (Mouse); 24629 (Rat)
Alternate Names
beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b antigen; CD140b; EC 2.7.10; EC 2.7.10.1; JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; PDGF-R-beta; platelet-derived growth factor receptor, beta polypeptide

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Citations for Mouse PDGF R beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

58 Citations: Showing 1 - 10
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  1. FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment
    Authors: Sun, Z;Yang, L;Kiram, A;Yang, J;Yang, Z;Xiao, L;Yin, Y;Liu, J;Mao, Y;Zhou, D;Yu, H;Zhou, Z;Xu, D;Jia, Y;Ding, C;Guo, Q;Wang, H;Li, Y;Wang, L;Fu, T;Hu, S;Gan, Z;
    Nature communications
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Postconditioning promotes recovery in the neurovascular unit after stroke
    Authors: Esposito, E;Licastro, E;Cuomo, O;Lo, EH;Hayakawa, K;Pignataro, G;
    Frontiers in cellular neuroscience
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  3. Anti-Fibrotic and Anti-Inflammatory Role of NO-Sensitive Guanylyl Cyclase in Murine Lung
    Authors: Englert, N;Burkard, P;Aue, A;Rosenwald, A;Nieswandt, B;Friebe, A;
    International journal of molecular sciences
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  4. Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/ beta -catenin signaling
    Authors: Biswas, S;Shahriar, S;Bachay, G;Arvanitis, P;Brunken, WJ;Agalliu, D;
    bioRxiv : the preprint server for biology
    Species: Transgenic Mouse, Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis
    Authors: Aue, A;Englert, N;Harrer, L;Schwiering, F;Gaab, A;König, P;Adams, R;Schmidtko, A;Friebe, A;Groneberg, D;
    Respiratory research
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
    Authors: Bennett, HC;Zhang, Q;Wu, YT;Chon, U;Pi, HJ;Drew, PJ;Kim, Y;
    bioRxiv : the preprint server for biology
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Cultured brain pericytes adopt an immature phenotype and require endothelial cells for expression of canonical markers and ECM genes
    Authors: Oliveira, F;Bondareva, O;Rodr�guez-Aguilera, JR;Sheikh, BN;
    Frontiers in cellular neuroscience
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  8. Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain
    Authors: N Romanò, C Lafont, P Campos, A Guillou, T Fiordelisi, DJ Hodson, P Mollard, M Schaeffer
    JCI Insight, 2023-02-08;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Confocal Imaging
  9. A Soluble Platelet-Derived Growth Factor Receptor-beta Originates via Pre-mRNA Splicing in the Healthy Brain and is Differentially Regulated during Hypoxia and Aging
    Authors: LB Payne, H Abdelazim, M Hoque, A Barnes, Z Mironovova, CE Willi, J Darden, C Jenkins-Ho, MW Sedovy, SR Johnstone, JC Chappell
    bioRxiv : the preprint server for biology, 2023-02-04;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  10. M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury
    Authors: L Cheng, M Zheng, J Jing, S Yu, Z Li, X Xu, F Yao, Y Luo, Y Liu
    Neural regeneration research, 2022-07-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  11. M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury
    Authors: SS Yu, ZY Li, XZ Xu, F Yao, Y Luo, YC Liu, L Cheng, MG Zheng, JH Jing
    Neural regeneration research, 2022-05-01;17(5):1072-1079.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRbeta pathway
    Authors: Z Li, S Yu, Y Liu, X Hu, Y Li, Z Xiao, Y Chen, D Tian, X Xu, L Cheng, M Zheng, J Jing
    Journal of Neuroinflammation, 2022-04-16;19(1):95.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  13. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation
    Authors: Q Zhao, W Dai, HY Chen, RE Jacobs, BV Zlokovic, BT Lund, A Montagne, A Bonnin
    Proceedings of the National Academy of Sciences of the United States of America, 2022-04-04;119(15):e2113310119.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-F
  14. Induction of osteogenesis by bone-targeted Notch activation
    Authors: C Xu, VV Dinh, K Kruse, HW Jeong, EC Watson, S Adams, F Berkenfeld, M Stehling, SJ Rasouli, R Fan, R Chen, I Bedzhov, Q Chen, K Kato, ME Pitulescu, RH Adams
    Elife, 2022-02-04;11(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Fascin-1 is Highly Expressed Specifically in Microglia After Spinal Cord Injury and Regulates Microglial Migration
    Authors: S Yu, L Cheng, D Tian, Z Li, F Yao, Y Luo, Y Liu, Z Zhu, M Zheng, J Jing
    Frontiers in Pharmacology, 2021-09-27;12(0):729524.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  16. KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state
    Authors: JW Lee, J Hur, YW Kwon, CW Chae, JI Choi, I Hwang, JY Yun, JA Kang, YE Choi, YH Kim, SE Lee, C Lee, DH Jo, H Seok, BS Cho, SH Baek, HS Kim
    Journal of hematology & oncology, 2021-09-16;14(1):148.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Expression of IL-20 Receptor Subunit beta Is Linked to EAE Neuropathology and CNS Neuroinflammation
    Authors: JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-, MM McMahon, L Cruz-Oreng
    Frontiers in Cellular Neuroscience, 2021-09-07;15(0):683687.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  18. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
    Authors: L Wang, D Sievert, AE Clark, S Lee, H Federman, BD Gastfriend, EV Shusta, SP Palecek, AF Carlin, JG Gleeson
    Nature Medicine, 2021-07-09;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  19. M2 Macrophages Promote PDGFR&beta+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFR&beta Pathway
    Authors: Z Li, M Zheng, S Yu, F Yao, Y Luo, Y Liu, D Tian, L Cheng, J Jing
    Frontiers in Pharmacology, 2021-04-15;12(0):670813.
    Species: Mouse
    Sample Types: Protein, Whole Cells, Whole Tissue
    Applications: ICC, IHC, Western Blot
  20. Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions
    Authors: TM O?Shea, AL Wollenberg, JH Kim, Y Ao, TJ Deming, MV Sofroniew
    Nature Communications, 2020-12-04;11(1):6203.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  21. Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice
    Authors: K Sakai, F Takata, G Yamanaka, M Yasunaga, K Hashiguchi, K Tominaga, K Itoh, Y Kataoka, A Yamauchi, S Dohgu
    Journal of pharmacological sciences, 2020-11-23;145(1):155-165.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha
    Authors: JL Kadrmas, MC Beckerle, M Yoshigi
    Sci Rep, 2020-11-09;10(1):19303.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  23. Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5
    Authors: JY Song, N Saga, K Kawanishi, K Hashikami, M Takeyama, M Nagata
    Sci Rep, 2020-11-03;10(1):18891.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  24. P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition
    Authors: E Vázquez-Ro, MK Shin, M Dhar, K Chaubey, CJ Cintrón-Pé, X Tang, X Liao, E Miller, Y Koh, S Barker, K Franke, DR Crosby, R Schroeder, J Emery, TC Yin, H Fujioka, JD Reynolds, MM Harper, MK Jain, AA Pieper
    Proc Natl Acad Sci U S A, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds
    Authors: HM Thomas, P Ahangar, BR Hofma, XL Strudwick, R Fitridge, SJ Mills, AJ Cowin
    Int J Mol Sci, 2020-08-05;21(16):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases
    Authors: AF Asega, MC Menezes, D Trevisan-S, D Cajado-Car, L Bertholim, AK Oliveira, A Zelanis, SMT Serrano
    Sci Rep, 2020-07-31;10(1):12912.
    Species: Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  27. Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature
    Authors: BN Sheikh, S Guhathakur, TH Tsang, M Schwabenla, G Renschler, B Herquel, V Bhardwaj, H Holz, T Stehle, O Bondareva, N Aizarani, O Mossad, O Kretz, W Reichardt, A Chatterjee, LJ Braun, J Thevenon, H Sartelet, T Blank, D Grün, D von Elverf, TB Huber, D Vestweber, S Avilov, M Prinz, JM Buescher, A Akhtar
    Nat. Cell Biol., 2020-06-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  28. Early Reperfusion Following Ischemic Stroke Provides Beneficial Effects, Even After Lethal Ischemia with Mature Neural Cell Death
    Authors: Y Tanaka, N Nakagomi, N Doe, A Nakano-Doi, T Sawano, T Takagi, T Matsuyama, S Yoshimura, T Nakagomi
    Cells, 2020-06-01;9(6):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Imatinib Sets Pericyte Mosaic in the Retina
    Authors: T Kovács-Öll, E Ivanova, G Szarka, ÁJ Tengölics, B Völgyi, BT Sagdullaev
    Int J Mol Sci, 2020-04-05;21(7):.
    Species: Mouse
    Sample Types: Tissue
    Applications: IHC-P
  30. Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells
    Authors: L Cai, SV Kirchleitn, D Zhao, M Li, JC Tonn, R Glass, RE Kälin
    Int J Mol Sci, 2020-01-17;21(2):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  31. Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy
    Authors: JH Wu, YN Li, AQ Chen, CD Hong, CL Zhang, HL Wang, YF Zhou, PC Li, Y Wang, L Mao, YP Xia, QW He, HJ Jin, ZY Yue, B Hu
    EMBO Mol Med, 2020-01-13;12(2):e10154.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung
    Authors: I Wojahn, TH Lüdtke, VM Christoffe, MO Trowe, A Kispert
    Respir. Res., 2019-12-23;20(1):292.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  33. The isolation and molecular characterization of cerebral microvessels
    Authors: YK Lee, H Uchida, H Smith, A Ito, T Sanchez
    Nat Protoc, 2019-10-04;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  34. GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury
    Authors: DY Chen, NH Sun, YP Lu, LJ Hong, TT Cui, CK Wang, XH Chen, SS Wang, LL Feng, WX Shi, K Fukunaga, Z Chen, YM Lu, F Han
    Theranostics, 2019-08-14;9(20):5937-5955.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  35. Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
    Authors: R Diéguez-Hu, K Kato, BD Giaimo, M Nieminen-K, H Arf, F Ferrante, M Bartkuhn, T Zimmermann, MG Bixel, HM Eilken, S Adams, T Borggrefe, P Vajkoczy, RH Adams
    Nat Commun, 2019-06-27;10(1):2817.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Straightforward method for singularized and region-specific CNS microvessels isolation
    Authors: J Rose Dayto, MC Franke, Y Yuan, L Cruz-Oreng
    J. Neurosci. Methods, 2019-02-21;0(0):.
    Species: Mouse, Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Tissue
    Applications: IHC
  37. Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts
    Authors: JK Lighthouse, RM Burke, LS Velasquez, RA Dirkx, A Aiezza, CS Moravec, JD Alexis, A Rosenberg, EM Small
    JCI Insight, 2019-01-10;4(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  38. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-?42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
    Authors: Q Ma, Z Zhao, AP Sagare, Y Wu, M Wang, NC Owens, PB Verghese, J Herz, DM Holtzman, BV Zlokovic
    Mol Neurodegener, 2018-10-19;13(1):57.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
    Authors: A Dubrac, SE Künzel, SH Künzel, J Li, RR Chandran, K Martin, DM Greif, RH Adams, A Eichmann
    Nat Commun, 2018-08-27;9(1):3463.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
    Authors: T Liu, W Ma, H Xu, M Huang, D Zhang, Z He, L Zhang, S Brem, DM O'Rourke, Y Gong, Y Mou, Z Zhang, Y Fan
    Nat Commun, 2018-08-27;9(1):3439.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Western Blot
  41. Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction
    Authors: R Nakazato, K Kawabe, D Yamada, S Ikeno, M Mieda, S Shimba, E Hinoi, Y Yoneda, T Takarada
    J. Neurosci., 2017-09-14;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
    Authors: R Tsutsumi, J Harizanova, R Stockert, K Schröder, PIH Bastiaens, BG Neel
    Nat Commun, 2017-09-06;8(1):466.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Western Blot
  43. Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis
    Authors: Jessica Duncombe
    Neuropathol. Appl. Neurobiol, 2017-03-27;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice
    Proc. Natl. Acad. Sci. U.S.A, 2016-12-12;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  45. VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination
    Nat Commun, 2016-11-23;7(0):13478.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  46. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation
    Cell Rep, 2016-11-22;17(9):2312-2325.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  47. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration
    Authors: WC Chen, Z Wang, MA Missinato, DW Park, DW Long, HJ Liu, X Zeng, NA Yates, K Kim, Y Wang
    Sci Adv, 2016-11-18;2(11):e1600844.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  48. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury
    Nat Med, 2016-09-26;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
    Nat Commun, 2016-05-03;7(0):11499.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
    Authors: Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R
    Dev Biol, 2015-11-02;409(1):218-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling.
    Authors: Pinto, Mauricio, Dye, Wendy W, Jacobsen, Britta M, Horwitz, Kathryn
    BMC Cancer, 2014-10-01;14(0):735.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC-P
  52. PGC-1alpha induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.
    Authors: Rowe G, Raghuram S, Jang C, Nagy J, Patten I, Goyal A, Chan M, Liu L, Jiang A, Spokes K, Beeler D, Dvorak H, Aird W, Arany Z
    Circ Res, 2014-07-09;115(5):504-17.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: ICC
  53. Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.
    Authors: Cruz-Orengo L, Daniels B, Dorsey D, Basak S, Grajales-Reyes J, McCandless E, Piccio L, Schmidt R, Cross A, Crosby S, Klein R
    J Clin Invest, 2014-05-08;124(6):2571-84.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  54. Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion.
    Authors: McQueen, Jamie, Reimer, Michell, Holland, Philip R, Manso, Yasmina, McLaughlin, Mark, Fowler, Jill H, Horsburgh, Karen
    PLoS ONE, 2014-02-03;9(2):e87227.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  55. Pericyte loss influences Alzheimer-like neurodegeneration in mice.
    Authors: Sagare A, Bell R, Zhao Z, Ma Q, Winkler E, Ramanathan A, Zlokovic B
    Nat Commun, 2013-01-01;4(0):2932.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  56. Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
    Authors: Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X
    J. Exp. Med., 2010-03-15;207(4):867-80.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  57. Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice.
    Authors: Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M, Funa K
    Mol. Cell. Neurosci., 2007-12-03;37(3):507-18.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  58. Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma.
    Authors: Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, Frantz GD, Hall L, Liang X, Gerber HP, Ferrara N
    Clin. Cancer Res., 2006-05-01;12(9):2676-88.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P

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Reviews for Mouse PDGF R beta Antibody

Average Rating: 4.3 (Based on 4 Reviews)

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Mouse PDGF R beta Antibody
By Anonymous on 09/18/2022
Application: Flow Sample Tested: Mouse ear fibroblast Species: Mouse

Works good


Mouse PDGF R beta Antibody
By jinxiu PAN on 10/13/2020
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Adult brain (hippocampus),Adult brain Species: Mouse

Mouse PDGF R beta Antibody
By Anonymous on 11/02/2016
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Brain tissue Species: Mouse

Mouse PDGF R beta Antibody
By Gaia Brezzo on 12/16/2015
Application: IHC Sample Tested: Brain tissue Species: Rat

Optimisation protocols of Microwave and Pressure Cooker antigen retrievals at pH6 and pH9. Concentrations 1:100, 1:200 and 1:400. In FFPE rat brain tissue. Primary antibody incubation 1 hr.