125 results for "ROCK2" in Products
ROCK2 Products
ROCK2/II (Rho-associated protein kinase 2; also Rho-kinase alpha) is a member of the AGC serine/threonine protein kinase family. ROCK2 is a downstream target of activated RhoA. Its activation results in myosin phosphorylation with subsequent muscle contraction. Human ROCK2 is 1388 amino acids (aa) in length, and appears to be present as a dimer. It contains a protein kinase domain (aa 92-354), a coiled-coil region (aa 429-1131) and a zinc-finger region (aa 1260-1315). Two isoforms show an alternate start site at M686, and a three aa substitution for the N-terminal 444 amino acids. Over aa 641-846, human ROCK2 shares 94% and 96% aa identity with mouse and canine ROCK2, respectively.
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
| Alternate Names: | y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor |
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥98% |
Y-27632 synthesized to cGMP guidelines
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥99% |
Selective Rho-kinase (ROCK) inhibitor
| Chemical Name: | (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride |
| Purity: | ≥98% |
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
| Chemical Name: | (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Immunohistochemistry-Paraffin: ROCK2 Antibody [NBP1-86124]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-Immunohistochemistry-Paraffin-NBP1-86124-img0014.jpg "Immunohistochemistry-Paraffin: ROCK2 Antibody [NBP1-86124]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 kappa Monoclonal Clone #1E12 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: ROCK2 Antibody (1E12) [H00009475-M02]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-1E12-Western-Blot-H00009475-M02-img0009.jpg "Western Blot: ROCK2 Antibody (1E12) [H00009475-M02]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Mycoplasma |
![Immunocytochemistry/ Immunofluorescence: ROCK2 Antibody [NBP2-20199]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-20199-img0005.jpg "Immunocytochemistry/ Immunofluorescence: ROCK2 Antibody [NBP2-20199]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #GT11712 |
| Applications: | IHC, WB |
![Western Blot: ROCK2 Antibody (GT11712) [NBP3-13535]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-GT11712-Western-Blot-NBP3-13535-img0007.jpg "Western Blot: ROCK2 Antibody (GT11712) [NBP3-13535]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
Inhibitor of cyclic nucleotide dependent- and Rho-kinases
| Alternate Names: | HA 1077 |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: ROCK2 AntibodyBSA Free [NBP1-76570]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-Western-Blot-NBP1-76570-img0001.jpg "Western Blot: ROCK2 AntibodyBSA Free [NBP1-76570]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JE31-36 |
| Applications: | IHC, WB, ICC/IF |
Potent and selective ROCK inhibitor
| Chemical Name: | N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide |
| Purity: | ≥98% |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #HL1071 |
| Applications: | WB, ICC/IF |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #8G3U2 |
| Applications: | IHC, WB, ELISA |
![Western Blot: ROCK2 Antibody (8G3U2) [NBP3-16123]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-8G3U2-Western-Blot-NBP3-16123-img0002.jpg "Western Blot: ROCK2 Antibody (8G3U2) [NBP3-16123]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IP |
![Western Blot: ROCK2 Antibody [NB100-593]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-Western-Blot-NB100-593-img0006.jpg "Western Blot: ROCK2 Antibody [NB100-593]")
Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
| Chemical Name: | (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride |
| Purity: | ≥98% |
Potent Rho-kinase inhibitor; vasodilator
| Chemical Name: | (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride |
| Purity: | ≥98% |
Potent and highly selective ROCK inhibitor; orally active
| Alternate Names: | Azaindole-1,BAY-549 |
| Chemical Name: | 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine |
| Purity: | ≥98% |
Potent and selective ROCK inhibitor; antitumor
| Chemical Name: | N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride |
| Purity: | ≥98% |
Potent ROCK inhibitor
| Chemical Name: | 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride |
| Purity: | ≥98% |
Potent and selective LIMK inhibitor; antitumor
| Chemical Name: | N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea |
| Purity: | ≥98% |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #10E1 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: ROCK2 Antibody (10E1) [NBP3-15152]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-10E1-Western-Blot-NBP3-15152-img0002.jpg "Western Blot: ROCK2 Antibody (10E1) [NBP3-15152]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S01-4F1 |
| Applications: | WB, ICC/IF |
![Western Blot: ROCK2 Antibody (S01-4F1) [NBP3-19508]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-S01-4F1-Western-Blot-NBP3-19508-img0002.jpg "Western Blot: ROCK2 Antibody (S01-4F1) [NBP3-19508]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: ROCK2 Antibody [NBP2-58122]](https://resources.rndsystems.com/images/products/ROCK2-Antibody-Western-Blot-NBP2-58122-img0003.jpg "Western Blot: ROCK2 Antibody [NBP2-58122]")