Proteome Profiler Human Angiogenesis Array Kit

Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
Catalog # Availability Size / Price Qty
Profiling Angiogenesis-Related Proteins in Human Cancer Tissues.
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Product Details
Citations (131)
Supplemental Products
Reviews (8)

Proteome Profiler Human Angiogenesis Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of selected angiogenesis-related proteins. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma and saliva.

Troubleshooting Guide

Key Benefits

  • Detects 55 human angiogenesis-related proteins simultaneously
  • Requires no specialized equipment
  • Compatible with LI-COR and chemiluminescence detection

Principle of the Assay

The Proteome Profiler Human Angiogenesis Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of bound analyte. Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules.

Why Use an Antibody Array to Detect Angiogenesis-Related Proteins?

Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.



Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Wash Buffer
  • Antibody Detection Cocktail
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

Simultaneously detect the relative levels of these angiogenesis-related proteins in a single sample.
Angiopoietin-1 HB-EGF Persephin
Angiopoietin-2 HGF CXCL4/PF4
Angiostatin/Plasminogen IGFBP-1 PlGF
Amphiregulin IGFBP-2 Prolactin
Artemin IGFBP-3 Serpin B5/Maspin
Tissue Factor/Factor III IL-1 beta Serpin E1/PAI-1
CXCL16 CXCL8/IL-8 Serpin F1/PEDF
DPPIV/CD26 LAP (TGF-beta 1) TIMP-1
EGF Leptin TIMP-4
EG-VEGF CCL2/MCP-1 Thrombospondin-1
Endoglin/CD105 CCL3/MIP-1 alpha Thrombospondin-2
Endostatin/Collagen XVIII MMP-8 uPA
Endothelin-1 MMP-9 Vasohibin
FGF acidic NRG1-beta 1 VEGF
FGF basic Pentraxin 3 VEGF-C


Assays for analytes represented in the Human Angiogenesis Antibody Array Kit

  Quantikine® ELISA Kits DuoSet® ELISA Development Systems Quantikine® HS (High Sensitivity) ELISA Kits QuantiGlo® Chemiluminescent ELISA Kits
Activin A DAC00B DY338    
ADAMTS-1   DY2197    
Angiogenin DAN00 DY265    
Angiopoietin-1 DANG10 DY923    
Angiopoietin-2 DANG20 DY623    
Amphiregulin   DY262    
Artemin   DY2589    
Tissue Factor/Factor III DCF300 DY2339    
CXCL16 DCX160 DY1164    
DPPIV/CD26   DY1180    
EGF DEG00 DY236    
EG-VEGF   DY1209    
Endoglin DNDG00 DY1097    
Endostatin/Collagen XVII DNST0 DY1098    
Endothelin-1 DET100     QET00B
FGF acidic DFA00B DY232    
FGF basic DFB50 DY233 HSFB00D  
FGF-4   DY235    
FGF-7/KGF DKG00 DY251    
GDNF   DY212    
HB-EGF   DY259    
HGF DHG00 DY294    
IGFBP-1   DY871    
IGFBP-2 DGB200 DY674    
IGFBP-3 DGB300 DY675    
IL-1 beta DLB50 DY201 HSLB00D QLB00B
CXCL8/IL-8 D8000C DY208 HS800 Q8000B
TGF-beta1 (LAP) DB100B DY240    
Leptin DLP00 DY398    
CCL2/MCP-1 DCP00 DY279    
CCL3/MIP-1 alpha DMA00 DY270    
MMP-8 DMP800 DY908    
MMP-9 DMP900 DY911    
NRG1-beta1   DY377    
Pentraxin 3 DPTX30 DY1826    
PDGF-AA DAA00B DY221    
PDGF-AB/PDGF-BB DHD00C, DBB00 DY222, DY220    
CXCL4/PF4   DY795    
PlGF DPG00 DY264    
Prolactin DPRL00 DY682    
Serpin B5/Maspin        
Serpin E1/PAI-1 DSE100 DY1786    
Serpin F1/PEDF        
TIMP-1 DTM100 DY970    
TIMP-4 DTM400 DY974    
Thrombospondin-1 DTSP10 DY3074    
Thrombospondin-2 DTSP20 DY1635    
uPA DUPA00 DY1310    
VEGF-C DVEC00 DY752B    

Angiogenesis is the tightly regulated process by which new blood vessels are formed from the existing vasculature. This process is physiologically important for development and wound healing, and is also a common driver in multiple diseases including rheumatoid arthritis, atherosclerosis, macular degeneration, and cancer. Angiogenesis occurs in response to a variety of molecular cues. Generally, the angiogenic process includes endothelial cell proliferation, chemotactic endothelial cell migration through the extracellular matrix barrier, and the formation of capillary tubes. Physiological and pathological angiogenesis utilize many of the same cellular processes and molecular signaling networks, however the structures that form during pathological angiogenesis are often functionally abnormal.


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Product Datasheets

Data Example

Profiling Angiogenesis-Related Proteins in Human Cancer Tissues. A) The Proteome Profiler Human Angiogenesis Antibody Array (Catalog # ARY007) was used to profile angiogenesis-related proteins in tissues from human prostate, ovarian, and breast cancers. B) Histogram profiles for select analytes were generated by quantifying the mean spot pixel densities from the array membrane using image software.

The Human Angiogenesis Array detects multiple analytes in cell culture supernates. A. THP-1 human acute monocytic leukemia cell line treated with 1 µg/mL Recombinant Human IFN-gamma (Catalog # 285-IF) for 8 hours and 1 µg/mL lipopolysaccharide (LPS) for 16 hours. B. HUVEC human umbilical vein endothelial cells treated with 10 mg/ml of LPS for 24 hours. 500 µL of supernate was used for each array shown. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.

The Human Angiogenesis Array detects multiple analytes in tissue lysate, serum, and plasma. Representative membranes and selective quantification are shown for human ovarian cancer tissue lysate (A., 200 µg), serum (B., 100 µL), and EDTA plasma (C., 100 µL). Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.

Citations for Proteome Profiler Human Angiogenesis Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

131 Citations: Showing 1 - 10
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  1. Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes
    Authors: E Nassar, N Hassan, EA El-Ghonaim, H Hassan, MS Abdullah, TV Rottke, L Kiesel, B Greve, SA Ibrahim, M Götte
    Cancers, 2021;13(10):.  2021
  2. Syndecan-1 Overexpressing Mesothelioma Cells Inhibit Proliferation, Wound Healing, and Tube Formation of Endothelial Cells
    Authors: J Javadi, G Heidari-Ha, A Schmalzl, T Szatmári, M Metintas, P Aspenström, A Hjerpe, K Dobra
    Cancers, 2021;13(4):.  2021
  3. Efficacy of chitinase-3-like protein 1 as an in�vivo bone formation predictable marker of maxillary/mandibular bone marrow stromal cells
    Authors: N Komabashir, F Suehiro, M Ishii, M Nishimura
    Regenerative Therapy, 2021;18(0):38-50.  2021
  4. Ricinus communis Butanol Fraction Inhibits MCF-7 Breast Cancer Cell Migration, Adhesion, and Invasiveness
    Authors: R Mabasa, K Malemela, K Serala, M Kgakishe, T Matsebatle, M Mokgotho, V Mbazima
    Integrative cancer therapies, 2021;20(0):1534735420977.  2021
  5. Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells
    Authors: Y Zhang, CK Elechalawa, MN Hossen, ER Francek, A Dey, S Wilhelm, R Bhattachar, P Mukherjee
    Bioact Mater, 2021;6(2):326-332.  2021
  6. RUNX3 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis
    Authors: K Heinze, M Hölzer, M Ungelenk, M Gerth, J Thomale, R Heller, CR Morden, KJ McManus, AS Mosig, M Dürst, IB Runnebaum, N Häfner
    Cancers, 2021;13(3):.  2021
  7. Serum-Derived Small Extracellular Vesicles From Diabetic Mice Impair Angiogenic Property of Microvascular Endothelial Cells: Role of EZH2
    Authors: Z Cheng, V Naga Srika, MM Truongcao, M Cimini, G Huang, C Wang, C Benedict, C Gonzalez, V Mallaredy, DA Goukassian, SK Verma, R Kishore
    Journal of the American Heart Association, 2021;10(10):e019755.  2021
  8. Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles
    Authors: AC Andrade, M Wolf, HM Binder, FG Gomes, F Manstein, P Ebner-Peki, R Poupardin, R Zweigerdt, K Schallmose, D Strunk
    International Journal of Molecular Sciences, 2021;22(8):.  2021
  9. Low RECK Expression Is Part of the Cervical Carcinogenesis Mechanisms
    Authors: S Herbster, M Trombetta-, PT de Souza-S, A Paladino, CRF Silveira, MC Sogayar, LL Villa, AP Lepique, E Boccardo
    Cancers, 2021;13(9):.  2021
  10. Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer
    Authors: SH Qin, ATY Lau, ZL Liang, HW Tan, YC Ji, QH Zhong, XY Zhao, YM Xu
    Cancers (Basel), 2020;12(4):.  2020
  11. Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature
    Authors: AG Kutikhin, AE Tupikin, VG Matveeva, DK Shishkova, LV Antonova, MR Kabilov, EA Velikanova
    Cells, 2020;9(4):.  2020
  12. An Active and Soft Hydrogel Actuator to Stimulate Live Cell Clusters by Self-folding
    Authors: JW Lim, HJ Kim, Y Kim, SG Shin, S Cho, WG Jung, JH Jeong
    Polymers (Basel), 2020;12(3):.  2020
  13. Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes
    Authors: TM Pausch, E Aue, NM Wirsik, A Freire Val, Y Shen, P Radhakrish, T Hackert, M Schneider, T Schmidt
    Sci Rep, 2020;10(1):5420.  2020
  14. Secretome of Senescent Adipose-Derived Mesenchymal Stem Cells Negatively Regulates Angiogenesis
    Authors: A Ratushnyy, M Ezdakova, L Buravkova
    Int J Mol Sci, 2020;21(5):.  2020
  15. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-&kappaB and sensitize to alkylating chemotherapy
    Authors: SJ Szymura, GM Bernal, L Wu, Z Zhang, CD Crawley, DJ Voce, PA Campbell, DE Ranoa, RR Weichselba, B Yamini
    BMC Biol., 2020;18(1):32.  2020
  16. ECM Mimetic Electrospun Porous Poly (L-lactic acid) (PLLA) Scaffolds as Potential Substrates for Cardiac Tissue Engineering
    Authors: P Muniyandi, V Palaninath, S Veeranaray, T Ukai, T Maekawa, T Hanajiri, MS Mohamed
    Polymers (Basel), 2020;12(2):.  2020
  17. Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions
    Authors: M Leite, MS Marques, J Melo, MT Pinto, B Cavadas, M Aroso, M Gomez-Laza, R Seruca, C Figueiredo
    Cells, 2020;9(2):.  2020
  18. Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells
    Authors: JJ Gu, J Hoj, C Rouse, AM Pendergast
    PLoS ONE, 2020;15(10):e0241423.  2020
  19. Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence
    Authors: K Hess, DC Spille, A Adeli, PB Sporns, K Zitta, L Hummitzsch, J Pfarr, W Stummer, B Brokinkel, R Berndt, M Albrecht
    Cancers (Basel), 2020;12(10):.  2020
  20. Proteomic Profiling Reveals the Ambivalent Character of the Mesenchymal Stem Cell Secretome: Assessing the Effect of Preconditioned Media on Isolated Human Islets
    Authors: H Brandhorst, D Brandhorst, A Abraham, S Acreman, SW Schive, H Scholz, PRV Johnson
    Cell Transplant, 2020;29(0):9636897209523.  2020
  21. In vitro modeling of solid tumor interactions with perfused blood vessels
    Authors: TJ Kwak, E Lee
    Sci Rep, 2020;10(1):20142.  2020
  22. Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model
    Authors: JE Chen, J Lumibao, S Leary, JN Sarkaria, AJ Steelman, HR Gaskins, BAC Harley
    J Neuroinflammation, 2020;17(1):346.  2020
  23. IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1, and IGFBP1
    Authors: X Li, N Niu, J Sun, Y Mou, X He, L Mei
    FEBS Open Bio, 2020;0(0):.  2020
  24. The Composition of Hyperacute Serum and Platelet-Rich Plasma Is Markedly Different despite the Similar Production Method
    Authors: D Kardos, M Simon, G Vácz, A Hinsenkamp, T Holczer, D Cseh, A Sárközi, K Szenthe, F Bánáti, S Szathmary, S Nehrer, O Kuten, M Masteling, Z Lacza, I Hornyák
    Int J Mol Sci, 2019;20(3):.  2019
  25. TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration
    Authors: K Lang, S Kahveci, N Bonberg, K Wichert, T Behrens, J Hovanec, F Roghmann, J Noldus, YC Tam, A Tannapfel, HU Käfferlein, T Brüning
    Int J Mol Sci, 2019;20(18):.  2019
  26. Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma-Enhanced Angiogenesis: A Novel Therapeutic Target?
    Authors: I Saltarella, MA Frassanito, A Lamanuzzi, A Brevi, P Leone, V Desantis, L Di Marzo, M Bellone, D Derudas, D Ribatti, R Chiaramont, MT Palano, A Neri, MA Mariggiò, R Fumarulo, F Dammacco, V Racanelli, A Vacca, R Ria
    Neoplasia, 2019;21(1):93-105.  2019
  27. Thrombin Preconditioning of Extracellular Vesicles Derived from Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing by Boosting Their Biogenesis and Enriching Cargo Content
    Authors: DK Sung, YS Chang, SI Sung, SY Ahn, WS Park
    J Clin Med, 2019;8(4):.  2019
  28. Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro
    Authors: L Hummitzsch, K Zitta, R Rusch, J Cremer, M Steinfath, J Gross, F Fandrich, R Berndt, M Albrecht
    Stem Cells Int, 2019;2019(0):3725863.  2019
  29. Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy
    Authors: G Xiong, W Tang, D Zhang, D He, G Wei, A Atala, XJ Liang, AJ Bleyer, ME Bleyer, J Yu, JA Aloi, JX Ma, CM Furdui, Y Zhang
    Theranostics, 2019;9(14):4221-4232.  2019
  30. Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts
    Authors: EE Hedlund, PC McDonald, O Nemirovsky, S Awrey, LDE Jensen, S Dedhar
    Cancers (Basel), 2019;11(7):.  2019
  31. Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
    Authors: T Matsui, T Chiyo, H Kobara, S Fujihara, K Fujita, D Namima, M Nakahara, N Kobayashi, N Nishiyama, T Yachida, A Morishita, H Iwama, T Masaki
    Int J Mol Sci, 2019;20(13):.  2019
  32. Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p
    Authors: C Gao, Z Gong, D Wang, J Huang, Y Qian, M Nie, W Jiang, X Liu, H Luo, J Yuan, T Xiang, S An, W Quan, H Wei, J Zhang, R Jiang
    Aging (Albany NY), 2019;11(24):12147-12164.  2019
  33. Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
    Authors: M Di Somma, W Schaafsma, E Grillo, M Vliora, E Dakou, M Corsini, C Ravelli, R Ronca, P Sakellario, J Vanparijs, B Castro, S Mitola
    Cells, 2019;8(11):.  2019
  34. The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
    Authors: KE Lee, SA Jung, YH Joo, EM Song, CM Moon, SE Kim, I Jo
    PLoS ONE, 2019;14(12):e0225739.  2019
  35. B-Cell Activating Factor Enhances Hepatocyte-Driven Angiogenesis via B-Cell CLL/Lymphoma 10/Nuclear Factor-KappaB Signaling during Liver Regeneration
    Authors: CH Chou, CM Ho, SL Lai, CN Chen, YM Wu, CT Shun, WF Wen, HS Lai
    Int J Mol Sci, 2019;20(20):.  2019
  36. Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
    Authors: J Kelleher, A Dickinson, S Cain, Y Hu, N Bates, A Harvey, J Ren, W Zhang, FC Moreton, KW Muir, C Ward, RM Touyz, P Sharma, Q Xu, SJ Kimber, T Wang
    Stem Cell Reports, 2019;13(5):817-831.  2019
  37. Extracellular Matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome
    Authors: G Biondani, K Zeeberg, MR Greco, S Cannone, I Dando, ED Pozza, M Mastrodona, S Forciniti, V Casavola, M Palmieri, SJ Reshkin, RA Cardone
    FEBS J., 2018;0(0):.  2018
  38. Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target
    Authors: EMM Abdelwahab, S Pal, K Kvell, V Sarosi, P Bai, R Rue, V Krymskaya, D McPhail, A Porter, JE Pongracz
    Oncogene, 2018;0(0):.  2018
  39. Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS
    Authors: CC Huang, CH Chou, SU Chen, HN Ho, YS Yang, MJ Chen
    J. Formos. Med. Assoc., 2018;0(0):.  2018
  40. Nintedanib inhibits growth of human prostate carcinoma cells by modulating both cell cycle and angiogenesis regulators
    Authors: RF da Silva, D Dhar, K Raina, D Kumar, R Kant, VHA Cagnon, C Agarwal, R Agarwal
    Sci Rep, 2018;8(1):9540.  2018
  41. Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema
    Authors: M Beerens, XL Aranguren, B Hendrickx, W Dheedene, T Dresselaer, U Himmelreic, C Verfaillie, A Luttun
    Sci Rep, 2018;8(1):3852.  2018
  42. Human dental pulp stromal cell conditioned medium alters endothelial cell behavior
    Authors: MA Gharaei, Y Xue, K Mustafa, SA Lie, I Fristad
    Stem Cell Res Ther, 2018;9(1):69.  2018
  43. A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells
    Authors: HK Kim, SG Lee, SW Lee, BJ Oh, JH Kim, JA Kim, G Lee, JD Jang, YA Joe
    Stem Cells, 2018;0(0):.  2018
  44. Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study
    Authors: L Rao, K De Veirman, D Giannico, I Saltarella, V Desantis, MA Frassanito, AG Solimando, D Ribatti, M Prete, A Harstrick, U Fiedler, H De Raeve, V Racanelli, K Vanderkerk, A Vacca
    Oncotarget, 2018;9(17):13366-13381.  2018
  45. Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
    Authors: CM Galmarini, M Martin, BP Bouchet, MJ Guillen-Na, M Martínez-D, JF Martinez-L, A Akhmanova, P Aviles
    BMC Cancer, 2018;18(1):164.  2018
  46. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells
    Authors: A Kim, JY Ma
    Front Pharmacol, 2018;9(0):1455.  2018
  47. Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions
    Authors: JUG Wagner, E Chavakis, EM Rogg, M Muhly-Rein, SF Glaser, S Günther, D John, F Bonini, AM Zeiher, L Schaefer, MJ Hannocks, RA Boon, S Dimmeler
    Arterioscler. Thromb. Vasc. Biol., 2018;0(0):.  2018
  48. Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer
    Authors: H Hagman, PO Bendahl, J Lidfeldt, M Belting, A Johnsson
    PLoS ONE, 2018;13(12):e0209838.  2018
  49. Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
    Authors: KP O'Brien, S Khan, KE Gilligan, H Zafar, P Lalor, C Glynn, C O'Flathart, H Ingoldsby, P Dockery, A De Bhulbh, JR Schweber, K St John, M Leahy, JM Murphy, WM Gallagher, T O'Brien, MJ Kerin, RM Dwyer
    Oncogene, 2018;0(0):.  2018
  50. Intranasal delivery of VEGF enhances compensatory lung growth in mice
    Authors: DT Dao, JT Vuong, L Anez-Busti, A Pan, PD Mitchell, GL Fell, MA Baker, DR Bielenberg, M Puder
    PLoS ONE, 2018;13(6):e0198700.  2018
  51. hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis
    Authors: BS Casas, G Vitória, MN do Costa, R Madeiro da, P Trindade, R Maciel, N Navarrete, SK Rehen, V Palma
    Transl Psychiatry, 2018;8(1):48.  2018
  52. Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer
    Authors: SL Lin, SM Wu, IH Chung, YH Lin, CY Chen, HC Chi, TK Lin, CT Yeh, KH Lin
    Neoplasia, 2018;20(1):57-68.  2018
  53. Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
    Authors: Y Wang, J Liu, Q Jiang, J Deng, F Xu, X Chen, F Cheng, Y Zhang, Y Yao, Z Xia, X Xu, X Su, M Huang, L Dai, Y Yang, S Zhang, D Yu, RC Zhao, Y Wei, H Deng
    Stem Cells, 2017;0(0):.  2017
  54. 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1
    Authors: S Tunçer, AG Ke?kü?, M Çolako?lu, I Çimen, C Yener, Ö Konu, S Banerjee
    Cell. Signal., 2017;39(0):44-54.  2017
  55. Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism
    Authors: R El Bezawy, M De Cesare, M Pennati, M Deraco, P Gandellini, V Zuco, N Zaffaroni
    J Hematol Oncol, 2017;10(1):19.  2017
  56. Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
    Authors: RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin
    Oncotarget, 2017;8(37):62081-62098.  2017
  57. Adipose progenitor cell secretion of GM-CSF and MMP9 promotes a stromal and immunological microenvironment that supports breast cancer progression
    Authors: F Reggiani, V Labanca, P Mancuso, C Rabascio, G Talarico, S Orecchioni, A Manconi, F Bertolini
    Cancer Res., 2017;0(0):.  2017
  58. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
    Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
    Autophagy, 2017;0(0):0.  2017
  59. Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
    Authors: A Gabrielyan, E Neumann, M Gelinsky, A Rösen-Wolf
    Stem Cell Res Ther, 2017;8(1):212.  2017
  60. Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells
    Authors: A Osborne, J Sanderson, KR Martin
    Stem Cells, 2017;0(0):.  2017
  61. Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells�(WJ-MSC)
    Authors: G Zavala, CP Prieto, AA Villanueva, V Palma
    Stem Cell Res Ther, 2017;8(1):203.  2017
  62. SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma
    Authors: R Bibes, S Gobron, F Vincent, C Mélin, N Vedrenne, A Perraud, F Labrousse, MO Jauberteau, F Lalloué
    Oncotarget, 2017;8(49):85969-85983.  2017
  63. Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
    Authors: SS Kim, JB Harford, M Moghe, A Rait, KF Pirollo, EH Chang
    Nucleic Acids Res., 2017;0(0):.  2017
  64. Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
    Authors: G Jin, Y Yang, K Liu, J Zhao, X Chen, H Liu, R Bai, X Li, Y Jiang, X Zhang, J Lu, Z Dong
    Oncogenesis, 2017;6(10):e384.  2017
  65. Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo
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  97. Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin.
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  99. Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression.
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  103. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
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    Stem Cells, 2014;32(3):694-705.  2014
  105. Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
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    Biomed Res Int, 2013;2013(0):492376.  2013
  106. A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
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    Stem Cells Dev, 2013;22(1):158-68.  2013
  108. A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma.
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  1. Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?

    • The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment. 

  2. What are the associated pathways each factor is involved in?

    • We do not have specific angiogenesis-related categorization of the target for this array, but we do have some informative material available in our website:

  3. Could you tell us whether this MMP-9 antibody can detect TIMP and MMP-9 complex?

    • We haven't performed a large amount of specificity testing per each spot in the arrays because these are qualitative screening tools. However, we would recommend treating the MMP-9 spot as a "Total MMP-9" detecting both free MMP-9 and MMP-9 in complex. If the MMP-9 spot turns out to be of high interest for the customer's study, they will want to examine this target in more detail with quantitative tools such as ELISA or Luminex.

  4. Which gene of the VEGF family is detected on E19 and E20

    • The VEGF spots are detecting VEGF-A.

  5. Does the Human Angiogenesis Proteome Profiler Array cross-react with other species like equines?

    • We have not tested this kit with equine samples. However, when looking at the cross reactivity with our Proteome Profiler Arrays, there are a few things to keep in mind. When the arrays are being designed, we look for the best antibodies that will work for the species stated. This does not mean there will not be any cross reactivity between species but it does suggest that the assay would not perform equally between species. While it is possible that some of the antibodies may detect the equine protein, different antibodies cross-react at different levels.

      It is also important to note that the Proteome Profiler Arrays are designed to be used as a screening tool. This may be a good place to start if you are trying determine what may be having an increase or a decrease in signal. We recommend running one untreated sample and comparing them to your treated samples. Even though you may not have the exact same cross reactivity with each analyte, you may be able to detect the increase or decrease from your samples.

      We have searched for citations that may have referenced using this kit with equine samples and were able to find 1. Here is the link to it:

View all Proteome Profiler Antibody Array FAQs

Reviews for Proteome Profiler Human Angiogenesis Array Kit

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Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 02/07/2019

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 02/06/2019

Worked well to look at THP-1 angiogenesis factors.

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 10/22/2018

It worked well in cell culture supernatants using 125 ug of total protein per membrane.

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 08/08/2018

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 05/17/2018

Used it on Conditioned medium collected from Breast Cancer Cells treated with Angiotensin II to look into its effect on Angiogenesis. Angiogenesis array worked really well and very easy to use. It provided some new promising gene targets which we did not know before.

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 04/01/2018

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 10/30/2017

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 12/06/2016

Human Angiogenesis Antibody Array was used to evaluate mesenchymal stem cells secretion profiles when seeded in various extracellular matrices. Great tool that ganarates lots of data!