Human CD11b/Integrin alpha M Antibody
Human CD11b/Integrin alpha M Antibody Summary
Phe17-Asn1105
Accession # NP_001139280
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD11b/Integrin alpha M
The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.
Product Datasheets
Citations for Human CD11b/Integrin alpha M Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation
Authors: T Horiguchi, A Tanimura, K Miyoshi, H Hagita, H Minami, T Noma
International Journal of Molecular Sciences, 2022;23(24):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Synergism between obesity and HFpEF on neutrophils phenotype and its regulation by adipose tissue-molecules and SGLT2i dapagliflozin
Authors: C Almengló, X Fu, MT Flores-Ari, ÁL Fernández, JE Viñuela, JM Martínez-C, D Durán, M Rodríguez-, JR González-J, S Eiras
Journal of Cellular and Molecular Medicine, 2022;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.
Authors: Tanimura, Ayako, Horiguchi, Taigo, Miyoshi, Keiko, Hagita, Hiroko, Noma, Takafumi
PLoS ONE, 2014;9(2):e89916.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammation.
BMC Neurosci, 2012;13(0):50.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-kappaB-dependent expression of CD55 in human monocytic THP-1 cells.
Authors: Izban M, Nowicki B, Nowicki S
PLoS ONE, 2012;7(11):e49318.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms.
Authors: Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K
J. Leukoc. Biol., 2007;83(3):728-41.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis.
Authors: Shi Y, Tohyama Y, Kadono T, He J, Shahjahan Miah SM, Hazama R, Tanaka C, Tohyama K, Yamamura H
Blood, 2006;107(11):4554-62.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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