Human Mcl-1 Antibody

Catalog # Availability Size / Price Qty
Mcl‑1 in Human Lymphoma.
1 Image
Product Details
Supplemental Products

Human Mcl-1 Antibody Summary

Species Reactivity
Detects human Mcl-1 in direct ELISAs.
Monoclonal Mouse IgG2B Clone # 602901
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human Mcl-1
Accession # Q07820
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Complete Your Experiment


Recommended Concentration
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry Mcl-1 antibody in Human Lymphoma by Immunohistochemistry (IHC-P). View Larger

Mcl‑1 in Human Lymphoma. Mcl-1 was detected in immersion fixed paraffin-embedded sections of human lymphoma using Mouse Anti-Human Mcl-1 Monoclonal Antibody (Catalog # MAB8281) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counter-stained with hematoxylin (blue). Specific staining was localized to the cytoplasm and plasma membranes of lymphocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Sterile PBS to a final concentration of 0.5 mg/mL.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Mcl-1

Mcl-1 (myeloid cell leukemia-1) is a member of the Bcl-2 family of proteins. Alternative splicing creates two distinct isoforms. The 40 kDa, 350 amino acid (aa) isoform 1, also known as Mcl-1L (long), enhances cell survival by inhibiting apoptosis, while the ~35 kDa, 271 aa isoform 2, also known as Mcl-1S (short; with divergence in the last 41 aa) promotes apoptosis. The elimination of Mcl-1L is a required step for DNA damage-induced apoptosis. Mcl-1 can be modified by phosphorylation on S121 and T163 by JNK, which triggers apoptosis, or polyubiquitination, which enhances degradation. Within aa 231-350 (unique to Mcl-1L), human Mcl-1 shares 93% and 96% aa identity with mouse and rat Mcl-1, respectively.

Long Name
Myeloid Cell Leukemia Sequence 1
Entrez Gene IDs
4170 (Human); 17210 (Mouse)
Alternate Names
BCL2L3; bcl2-L-3; BCL2L3MGC104264; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MGC1839; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); TM

Product Datasheets

You must select a language.



No product specific FAQs exist for this product, however you may

View all Antibody FAQs

Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Reviews for Human Mcl-1 Antibody

There are currently no reviews for this product. Be the first to review Human Mcl-1 Antibody and earn rewards!

Have you used Human Mcl-1 Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review