Human/Mouse/Rat RAGE/AGER Antibody

Catalog # Availability Size / Price Qty
AF1145
AF1145-SP
Detection of Human, Mouse, and Rat RAGE by Western Blot.
12 Images
Product Details
Citations (37)
FAQs
Supplemental Products
Reviews (1)

Human/Mouse/Rat RAGE/AGER Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human RAGE in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human RAGE
Gln24-Ala344
Accession # Q15109
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Immunohistochemistry
0.5-15 µg/mL
See below
Blockade of Receptor-ligand Interaction
In a functional ELISA, 8-40 µg/mL of this antibody will block 50% of the binding of 500 ng/mL of biotinylated AGE‑BSA to immobilized Recombinant Human RAGE Fc Chimera (Catalog # 1145-RG) coated at 5 µg/mL (100 µL/well). At 100 μg/mL, this antibody will block >90% of the binding.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human, Mouse, and Rat RAGE antibody by Western Blot. View Larger

Detection of Human, Mouse, and Rat RAGE by Western Blot. Western blot shows lysates of human, mouse, and rat lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat RAGE Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1145) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for RAGE at approximately 45-55 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Western Blot Detection of Human RAGE antibody by Western Blot. View Larger

Detection of Human RAGE by Western Blot. Western blot shows lysates of human lung tissue and HEK001 human epidermal keratinocyte cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat RAGE Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1145) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for RAGE at approximately 43 kDa under non-reducing (NR) conditions and 50 kDa under reducing (R) conditions (as indicated). This experiment was conducted using Immunoblot Buffer Group 5.

Immunohistochemistry RAGE antibody in Human Alzheimer's Disease Brain by Immunohistochemistry (IHC-P). View Larger

RAGE in Human Alzheimer's Disease Brain. RAGE was detected in immersion fixed paraffin-embedded sections of human Alzheimer's disease brain (cerebellum) using 15 µg/mL Goat Anti-Human/Mouse/Rat RAGE Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1145) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry RAGE antibody in Human Lung by Immunohistochemistry (IHC-P). View Larger

RAGE in Human Lung. RAGE was detected in immersion fixed paraffin-embedded sections of human lung using Goat Anti-Human/Mouse/Rat RAGE Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1145) at 0.5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell membranes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Western Blot Detection of Mouse AGER by Western Blot View Larger

Detection of Mouse AGER by Western Blot RAGE expression mediates cell aggregation through homophilic interactions.(A) Western blot analysis on control preB 300.19 cells (preB/pCAGS) or expressing FL-RAGE (preB/FL-RAGE) using alpha RAGE N-term1 antibody. Forty µg of cell lysate were loaded and detection of GAPDH was used as loading control. (B) Cell aggregation assay. preB/pCAGS or preB/FL-RAGE cells were cultured for 2, 6 or 24 hours before being photographed at 20× magnification in phase contrast (left panel). Bar corresponds to 50 µm. Quantification of cell aggregates area (right panel). Results are displayed as means±SEM (*, P<0.05; **, P<0.01; ***, P<0.0001). (C) Mixed cell aggregation assay. Red preB (Red-preB) or preB/FL-RAGE (expressing GFP; preB/FL-RAGE-GFP) cells were grown as single cell line suspension or mixed in equal number for 24 hours. Red-preB/FL-RAGE-GFP were mixed with preB/FL-RAGE-GFP for the same time. Bar corresponds to 50 µm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24475194), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Rat AGER by Western Blot View Larger

Detection of Rat AGER by Western Blot RAGE expression enhances cell-matrix adhesion.(A) Western blot analysis on rat lung lysate and R3/1 cells using three different antibodies recognizing RAGE extracellular (anti-RAGE N-term1 and anti-RAGE N-term2) or intracellular (anti-RAGE C-term) domains. Asterisk (*) indicates nonspecific bands. Forty µg of cell lysate were loaded and detection of GAPDH was used as loading control. (B) Western blot analysis on R3/1-pLXSN and R3/1-FL-RAGE cells using anti-RAGE N-term1 antibody. Forty µg of cell lysate were loaded and detection of GAPDH was used as loading control. (C, D) Cell-matrix adhesion assay. Adhesion of R3/1-pLXSN or R3/1-FL-RAGE cells onto culture dishes coated with 10 µg/ml ECM proteins. Adhesion to PBS, collagen I (Coll I), Fibronectin (FN), or Laminin (Lam) was assayed for 15 minutes (C) or 45 minutes (D). One representative experiment out of three is shown. Results from triplicate wells are displayed as means±SEM (ns, not significant; *, P<0.05; **, P<0.01). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24475194), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human AGER by Immunohistochemistry View Larger

Detection of Human AGER by Immunohistochemistry Differential expression of RAGE and S100A8/A9 on protein level in whole skin.The expression level was analysed by immunochistochemistry using specific anti human S100A8/A9 and anti human RAGE antibodies. The expression was tested in 5 patient samples per group (IC and OTR with in situ or invasive SCC). a: Expression of RAGE and S100A8/A9 in IC and OTR patients with in situ SCC in comparison to normal skin. b: Expression of RAGE and S100A8/A9 in IC and OTR patient with invasive SCC in comparison to normal skin. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0120971), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Rat AGER by Western Blot View Larger

Detection of Rat AGER by Western Blot RAGE expression enhances cell-matrix adhesion.(A) Western blot analysis on rat lung lysate and R3/1 cells using three different antibodies recognizing RAGE extracellular (anti-RAGE N-term1 and anti-RAGE N-term2) or intracellular (anti-RAGE C-term) domains. Asterisk (*) indicates nonspecific bands. Forty µg of cell lysate were loaded and detection of GAPDH was used as loading control. (B) Western blot analysis on R3/1-pLXSN and R3/1-FL-RAGE cells using anti-RAGE N-term1 antibody. Forty µg of cell lysate were loaded and detection of GAPDH was used as loading control. (C, D) Cell-matrix adhesion assay. Adhesion of R3/1-pLXSN or R3/1-FL-RAGE cells onto culture dishes coated with 10 µg/ml ECM proteins. Adhesion to PBS, collagen I (Coll I), Fibronectin (FN), or Laminin (Lam) was assayed for 15 minutes (C) or 45 minutes (D). One representative experiment out of three is shown. Results from triplicate wells are displayed as means±SEM (ns, not significant; *, P<0.05; **, P<0.01). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24475194), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human AGER by Immunohistochemistry View Larger

Detection of Human AGER by Immunohistochemistry Differential expression of RAGE and S100A8/A9 on protein level in whole skin.The expression level was analysed by immunochistochemistry using specific anti human S100A8/A9 and anti human RAGE antibodies. The expression was tested in 5 patient samples per group (IC and OTR with in situ or invasive SCC). a: Expression of RAGE and S100A8/A9 in IC and OTR patients with in situ SCC in comparison to normal skin. b: Expression of RAGE and S100A8/A9 in IC and OTR patient with invasive SCC in comparison to normal skin. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0120971), licensed under a CC-BY license. Not internally tested by R&D Systems.

Flow Cytometry Detection of Human AGER by Flow Cytometry View Larger

Detection of Human AGER by Flow Cytometry Exogenous S100A8/A9 induces keratinocyte proliferation.a: Assessment of the proliferation by BrdU assay. To assess the role of S100A8/A9 in normal primary, AK and SCC cultures, they were treated with purified S100A8/A9 for 24 hours and proliferation was assessed by BrdU incorporation. The induction of cellular proliferation was between 30–70% (2 way Anova, p<0.0001). b: Assessment of the proliferation by the incorporation of BrdU analysed by flow cytrometry. Normal keratinocytes were treated with S100A8/A9 (10ng/ml) and BrdU for 24 hours. Afterwards cells were fixed in 4% PFA, permeabilized with 0.5% Triton and stained for RAGE and BrdU using the antibodies mentioned above. The differential BrdU incorporation was compared to untreated cell. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0120971), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human AGER by Western Blot View Larger

Detection of Human AGER by Western Blot RAGE expression contributes to cell-cell adhesion.(A) Western blot analysis on control HEK cells (HEK/pcDNA) or expressing FL-RAGE (HEK/FL-RAGE) using anti-RAGE N-term1 antibody. Forty µg of cell lysate were loaded and detection of GAPDH was used as loading control. (B) A dissociation assay was performed by applying mechanical force on monolayers of HEK/pcDNA or HEK/FL-RAGE cells. Photographs were taken at 40× magnification in phase contrast. Bar corresponds to 50 µm. The dissociation index is the means±SEM of three independent experiments (**, P<0.01). (C) Localization of FL-RAGE on HEK/pcDNA, HEK/FL-RAGE or a mix of both cell lines (orange). Nuclei are stained in blue. Red arrows indicate HEK/pcDNA cells in contact with HEK/FL-RAGE. Green arrows indicate HEK/FL-RAGE cells in contact with each other. Bar corresponds to 10 µm. (D) Localization of FL-RAGE on R3/1-pLXSN, R3/1-FL-RAGE or a mix of both cell lines (orange). Nuclei are stained in blue. Red arrows indicate R3/1-pLXSN cells in contact with R3/1-FL-RAGE. Green arrows indicates R3/1-FL-RAGE cells in contact with each other. Red arrows indicate cells not expressing RAGE in contact with cells expressing RAGE. Bar corresponds to 10 µm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24475194), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human AGER by Western Blot View Larger

Detection of Human AGER by Western Blot The receptor RAGE critically mediates the cellular response to S100A8/A9.a: Direct blockade by a specific RAGE blocking antibody reduces cellular proliferation. RAGE dependent proliferation was analyzed in normal primary, AK and SCC cells. Cells were incubated for 1 hour with a blocking anti-RAGE antibody (80μg/ml, as recommended by manufacturer) followed by S100A8/A9 stimulation for additional 24 hours. The differences in the proliferation after the blockade were assessed by BrdU incorporation (1 way Anova, Bonferroni`s Multiple test, **p<0.05, ***p<0.05). b: Knockdown of RAGE using shRNA reduces cellular proliferation. The knockdown studies were performed using specific lentiviral shRNA against RAGE. Primary keratinocytes were infected by shRAGE and sh control viral particles. Selection of positive clones was performed by puromycine selection. Cells were grown to optimal confluence and were stimulated with 10ng/ml S100A8/A9.Cells with RAGE knockdown showed a delay in proliferation in comparison to control as assessed by BrdU (70%) (1 way Anova, Bonferroni`s Multiple test p****<0.0001) and microscope images. Exogenous S100A8/A9 did not induce proliferation of shRAGE keratinocytes, but only in the control. c: Blocking TLR4 using specific blocking antibody (HTA125) does not impair cellular proliferation. AK cells were treated with a specific blocking TLR4 antibody (HTA125). AK cells were grown for 24 hours in the presence of HTA125 antibody (1μg/ml) and S100A8/A9 (10ng/ml). For detection of the cellular proliferation rate BrdU proliferation assay was performed. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0120971), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

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Reconstitute at 0.2 mg/mL in sterile PBS.
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The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: RAGE/AGER

Advanced glycation endproducts (AGE) are adducts formed by the non-enzymatic glycation or oxidation of macromolecules. AGE forms during aging and its formation is accelerated under pathophysiologic states such as diabetes, Alzheimer’s disease, renal failure and immune/inflammatory disorders. Receptor for Advanced Glycation Endoproducts (RAGE), named for its ability to bind AGE, is a multi-ligand receptor belonging the immunoglobulin (Ig) superfamily. Besides AGE, RAGE binds amyloid beta -peptide, S100/calgranulin family proteins, high mobility group B1 (HMGB1, also know as amphoterin) and leukocyte integrins.

The human RAGE gene encodes a 404 amino acid residues (aa) type I transmembrane glycoprotein with a 22 aa signal peptide, a 320 aa extracellular domain containing an Ig-like V-type domain and two Ig-like Ce-type domains, a 21 aa transmembrane domain and a 41 aa cytoplasmic domain. The V-type domain and the cytoplasmic domain are important for ligand binding and for intracellular signaling, respectively. Two alternative splice variants, lacking the V-type domain or the cytoplasmic tail, are known. RAGE is highly expressed in the embryonic central nervous system. In adult tissues, RAGE is expressed at low levels in multiple tissues including endothelial and smooth muscle cells, mononuclear phagocytes, pericytes, microglia, neurons, cardiac myocytes, and hepatocytes. The expression of RAGE is upregulated upon ligand interaction. Depending on the cellular context and interacting ligand, RAGE activation can trigger differential signaling pathways that affect divergent pathways of gene expression. RAGE activation modulates varied essential cellular responses (including inflammation, immunity, proliferation, cellular adhesion, and migration) that contribute to cellular dysfunction associated with chronic diseases such as diabetes, cancer, amyloidoses, and immune or inflammatory disorders.

Long Name
Receptor for Advanced Glycation End Products
Entrez Gene IDs
177 (Human); 11596 (Mouse); 81722 (Rat); 403168 (Canine)
Alternate Names
advanced glycosylation end product-specific receptor; AGER; RAGE isoform delta; RAGE isoform sRAGE-delta; RAGE; Receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products; SCARJ1

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Citations for Human/Mouse/Rat RAGE/AGER Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

37 Citations: Showing 1 - 10
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  1. YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1
    Authors: Gokey J, Snowball J, Sridharan A Et al.
    iScience
  2. AGE-RAGE interaction in the TGF?2-mediated epithelial to mesenchymal transition of human lens epithelial cells.
    Authors: Cibin T Raghavan, Ram H Nagaraj
    Glycoconjugate Journal, 2016-06-04;0(0):1573-4986.
  3. Human intestine and placenta exhibit tissue-specific expression of RAGE isoforms
    Authors: Schwertner, K;Gelles, K;Leitner, J;Steinberger, P;Gundacker, C;Vrticka, R;Hoffmann-Sommergruber, K;Ellinger, I;Geiselhart, S;
    Heliyon
    Species: Human
    Sample Types: Cell Lysates, Tissue Homogenates, Whole Cells, Whole Tissue
    Applications: IHC, ICC, Western Blot
  4. RAGE/SNAIL1 signaling drives epithelial-mesenchymal plasticity in metastatic triple-negative breast cancer
    Authors: Pujals, M;Mayans, C;Bellio, C;Méndez, O;Greco, E;Fasani, R;Alemany-Chavarria, M;Zamora, E;Padilla, L;Mitjans, F;Nuciforo, P;Canals, F;Nonell, L;Abad, M;Saura, C;Tabernero, J;Villanueva, J;
    Oncogene
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  5. p53 governs an AT1 differentiation programme in lung cancer suppression
    Authors: Kaiser, AM;Gatto, A;Hanson, KJ;Zhao, RL;Raj, N;Ozawa, MG;Seoane, JA;Bieging-Rolett, KT;Wang, M;Li, I;Trope, WL;Liou, DZ;Shrager, JB;Plevritis, SK;Newman, AM;Van Rechem, C;Attardi, LD;
    Nature
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Alveolar repair following lipopolysaccharide-induced injury requires cell-extracellular matrix interactions
    Authors: Sucre, JM;Bock, F;Negretti, NM;Benjamin, JT;Gulleman, PM;Dong, X;Ferguson, KT;Jetter, CS;Han, W;Liu, Y;Kook, S;Gokey, JJ;Guttentag, SH;Kropski, JA;Blackwell, TS;Zent, R;Plosa, EJ;
    JCI insight
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration
    Authors: Arvind Konkimalla, Satoshi Konishi, Yoshihiko Kobayashi, Preetish Kadur Lakshminarasimha Murthy, Lauren Macadlo, Ananya Mukherjee et al.
    iScience
  8. High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE‐KO mice
    Authors: Danielle N. D'Erminio, Divya Krishnamoorthy, Alon Lai, Robert C. Hoy, Devorah M. Natelson, Jashvant Poeran et al.
    Journal of Orthopaedic Research
  9. Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures
    Authors: Satoshi Konishi, Aleksandra Tata, Purushothama Rao Tata
    STAR Protocols
  10. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
    Authors: P Kadur Laks, V Sontake, A Tata, Y Kobayashi, L Macadlo, K Okuda, AS Conchola, S Nakano, S Gregory, LA Miller, JR Spence, JF Engelhardt, RC Boucher, JR Rock, SH Randell, PR Tata
    Nature, 2022-03-30;604(7904):111-119.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  11. A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties
    Authors: F Havas, S Krispin, M Cohen, E Loing, M Farge, T Suere, J Attia-Vign
    Marine Drugs, 2022-01-27;20(2):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  12. A census of the lung: CellCards from LungMAP
    Authors: Xin Sun, Anne-Karina Perl, Rongbo Li, Sheila M. Bell, Eniko Sajti, Vladimir V. Kalinichenko et al.
    Developmental Cell
  13. Extracellular Histones Bind Vascular Glycosaminoglycans and Inhibit the Anti-Inflammatory Function of Antithrombin
    Authors: Indranil Biswas, Sumith R. Panicker, Xiaofeng S. Cai, Hemant Giri, Alireza R. Rezaie
    Cellular Physiology and Biochemistry
  14. Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis
    Authors: F Scavello, F Zeni, G Milano, F Macrì, S Castiglion, E Zuccolo, A Scopece, G Pezone, CC Tedesco, P Nigro, G Degani, E Gambini, F Veglia, L Popolo, G Pompilio, GI Colombo, ME Bianchi, A Raucci
    International journal of biological sciences, 2021-06-11;17(10):2399-2416.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  15. Inhibition of the Receptor for Advanced Glycation End Products Enhances the Cytotoxic Effect of Gemcitabine in Murine Pancreatic Tumors
    Authors: P Swami, KA O'Connell, S Thiyagaraj, A Crawford, P Patil, P Radhakrish, S Shin, TC Caffrey, J Grunkemeye, T Neville, SW Vetter, MA Hollingswo, E Leclerc
    Biomolecules, 2021-04-01;11(4):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  16. Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2
    Authors: J Youk, T Kim, KV Evans, YI Jeong, Y Hur, SP Hong, JH Kim, K Yi, SY Kim, KJ Na, T Bleazard, HM Kim, M Fellows, KT Mahbubani, K Saeb-Parsy, SY Kim, YT Kim, GY Koh, BS Choi, YS Ju, JH Lee
    Cell Stem Cell, 2020-10-21;27(6):905-919.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  17. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction
    Authors: H Katsura, V Sontake, A Tata, Y Kobayashi, CE Edwards, BE Heaton, A Konkimalla, T Asakura, Y Mikami, EJ Fritch, PJ Lee, NS Heaton, RC Boucher, SH Randell, RS Baric, PR Tata
    Cell Stem Cell, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  18. Role of the Receptor for Advanced Glycation End Products in Heat Stress-Induced Endothelial Hyperpermeability in Acute Lung Injury
    Authors: Gengbiao Zhou, Zhenfeng Chen, Jieyu Li, Xiaotong Guo, Kaiwen Qin, Jiaqi Luo et al.
    Frontiers in Physiology
  19. Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging
    Authors: F Scavello, F Zeni, CC Tedesco, E Mensà, F Veglia, AD Procopio, AR Bonfigli, F Olivieri, A Raucci
    Aging (Albany NY), 2019-03-23;11(6):1648-1663.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  20. EMC3 coordinates surfactant protein and lipid homeostasis required for respiration
    Authors: X Tang, JM Snowball, Y Xu, CL Na, TE Weaver, G Clair, JE Kyle, EM Zink, C Ansong, W Wei, M Huang, X Lin, JA Whitsett
    J. Clin. Invest., 2017-10-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  21. The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis
    PLoS ONE, 2016-09-27;11(9):e0163330.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  22. The Mouse-Specific Splice Variant mRAGE_v4 Encodes a Membrane-Bound RAGE That Is Resistant to Shedding and Does Not Contribute to the Production of Soluble RAGE
    PLoS ONE, 2016-09-21;11(9):e0153832.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: IHC, Western Blot
  23. RAGE mediated intracellular A beta uptake contributes to the breakdown of tight junction in retinal pigment epithelium
    Authors: Sung Wook Park, Jin Hyoung Kim, Sang Min Park, Minho Moon, Ki Hwang Lee, Kyu Hyung Park et al.
    Oncotarget
  24. S100A8/A9 stimulates keratinocyte proliferation in the development of squamous cell carcinoma of the skin via the receptor for advanced glycation-end products.
    Authors: Iotzova-Weiss G, Dziunycz P, Freiberger S, Lauchli S, Hafner J, Vogl T, French L, Hofbauer G
    PLoS ONE, 2015-03-26;10(3):e0120971.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC-P, Neutralization
  25. Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death.
    Authors: Vogel S, Borger V, Peters C, Forster M, Liebfried P, Metzger K, Meisel R, Daubener W, Trapp T, Fischer J, Gawaz M, Sorg R
    Cell Death Differ, 2015-01-09;22(7):1219-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  26. Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation.
    Authors: Winden D, Barton D, Betteridge B, Bodine J, Jones C, Rogers G, Chavarria M, Wright A, Jergensen Z, Jimenez F, Reynolds P
    Respir Res, 2014-10-23;15(0):129.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-P, Western Blot
  27. Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology.
    Authors: Moser B, Janik S, Schiefer A, Mullauer L, Bekos C, Scharrer A, Mildner M, Renyi-Vamos F, Klepetko W, Ankersmit H
    PLoS ONE, 2014-04-04;9(4):e94118.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  28. Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFbeta1.
    Authors: Basso D, Bozzato D, Padoan A, Moz S, Zambon C, Fogar P, Greco E, Scorzeto M, Simonato F, Navaglia F, Fassan M, Pelloso M, Dupont S, Pedrazzoli S, Fassina A, Plebani M
    Cell Commun Signal, 2014-03-26;12(0):20.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  29. Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET.
    Authors: Vogel S, Chatterjee M, Metzger K, Borst O, Geisler T, Seizer P, Muller I, Mack A, Schumann S, Buhring H, Lang F, Sorg R, Langer H, Gawaz M
    J Biol Chem, 2014-02-24;289(16):11068-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  30. The receptor for advanced glycation end-products (RAGE) is only present in mammals, and belongs to a family of cell adhesion molecules (CAMs).
    Authors: Sessa L, Gatti E, Zeni F, Antonelli A, Catucci A, Koch M, Pompilio G, Fritz G, Raucci A, Bianchi M
    PLoS ONE, 2014-01-27;9(1):e86903.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  31. Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 2.
    Authors: Monden, Masayo, Koyama, Hidenori, Otsuka, Yoshiko, Morioka, Tomoaki, Mori, Katsuhit, Shoji, Takuhito, Mima, Yohei, Motoyama, Koka, Fukumoto, Shinya, Shioi, Atsushi, Emoto, Masanori, Yamamoto, Yasuhiko, Yamamoto, Hiroshi, Nishizawa, Yoshiki, Kurajoh, Masafumi, Yamamoto, Tetsuya, Inaba, Masaaki
    Diabetes, 2012-09-25;62(2):478-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  32. Novel Sulfated Polysaccharides Disrupt Cathelicidins, Inhibit RAGE and Reduce Cutaneous Inflammation in a Mouse Model of Rosacea
    Authors: Jianxing Zhang, Xiaoyu Xu, Narayanam V. Rao, Brian Argyle, Lindsi McCoard, William J. Rusho et al.
    PLoS ONE
  33. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands.
    Authors: Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, MacArthur RB, Walters BB, Hoidal JR, Kennedy TP
    Am. J. Physiol., Cell Physiol., 2010-04-07;299(1):C97-110.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  34. In vitro effects of atorvastatin on lipopolysaccharide-induced gene expression in endometriotic stromal cells.
    Authors: Sharma I, Dhawan V, Mahajan N, Saha SC, Dhaliwal LK
    Fertil. Steril., 2009-11-26;94(5):1639.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  35. Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus.
    Authors: Mallidis C, Agbaje I, Rogers D, Glenn J, McCullough S, Atkinson AB, Steger K, Stitt A, McClure N
    Hum. Reprod., 2007-06-21;22(8):2169-77.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  36. Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium.
    Authors: Zen K, Chen CX, Chen YT, Wilton R, Liu Y
    J. Immunol., 2007-02-15;178(4):2483-90.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  37. Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro.
    Authors: Wang J, Edeen K, Manzer R, Chang Y, Wang S, Chen X, Funk CJ, Cosgrove GP, Fang X, Mason RJ
    Am. J. Respir. Cell Mol. Biol., 2007-01-25;36(6):661-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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Human/Mouse/Rat RAGE Antibody
By Balaji Mahender on 12/06/2017
Application: ELISA Sample Tested: EDTA Plasma,Heparin Plasma,Platelet-poor EDTA Plasma Species: Human