Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA

    
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Preparation and Storage
  • Stability & Storage
    Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Nicotinic Acetylcholine R alpha 7/CHRNA7
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • Long Name:
    Nicotinic Acetylcholine Receptor alpha 7
  • Entrez Gene IDs:
    1139 (Human); 11441 (Mouse); 25302 (Rat)
  • Alternate Names:
    a7 nicotinic acetylcholine receptor; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; cholinergic receptor, nicotinic, alpha 7; cholinergic receptor, nicotinic, alpha polypeptide 7; CHRNA7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal acetylcholine receptor subunit alpha-7; Nicotinic Acetylcholine R alpha 7; Nicotinic Acetylcholine Ra 7
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