Human ST6 Gal Sialyltransferase 1/
ST6GAL1 Antibody

Catalog # Availability Size / Price Qty
AF5924
AF5924-SP
Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1 by Western Blot.
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Product Details
Citations (29)
FAQs
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Reviews (1)

Human ST6 Gal Sialyltransferase 1/
ST6GAL1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human ST6 Gal Sialyltransferase 1/ST6GAL1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ST6 Gal Sialyltransferase 1/ST6GAL1
Lys27-Cys406
Accession # P15907
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunohistochemistry
0.3-15 µg/mL
Immersion fixed paraffin-embedded sections of human liver and immersion fixed paraffin-embedded sections of human prostate
Immunocytochemistry
5-15 µg/mL
Immersion fixed U266 human myeloma cell line (Positive) & RT‑4 human urinary bladder transitional cell papilloma cell line (Negative)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human ST6GAL1 antibody by Western Blot. View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1 by Western Blot. Western blot shows lysates of Daudi human Burkitt's lymphoma cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5924) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF019). A specific band was detected for ST6GAL1 at approximately 56 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Immunohistochemistry View Larger

ST6 Gal Sialyltransferase 1/ST6GAL1 in Human Liver. ST6 Gal Sialyltransferase 1/ST6GAL1 was detected in immersion fixed paraffin-embedded sections of human liver using Goat Anti-Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5924) at 0.3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in hepatocytes. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry View Larger

ST6 Gal Sialyltransferase 1/ST6GAL1 in Human Prostate. ST6 Gal Sialyltransferase 1/ST6GAL1 was detected in immersion fixed paraffin-embedded sections of human prostate using Goat Anti-Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5924) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in glandular epithelial cells. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1 antibody by Simple Western<SUP>TM</SUP>. View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1 by Simple WesternTM. Simple Western lane view shows lysates of Daudi human Burkitt's lymphoma cell line, loaded at 0.2 mg/mL. A specific band was detected for ST6 Gal Sialyltransferase 1/ST6GAL1 at approximately 64 kDa (as indicated) using 10 µg/mL of Goat Anti-Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5924) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Immunocytochemistry View Larger

Detection of ST6 Gal Sialyltransferase 1/ST6GAL1 in U266 human myeloma cell line (Positive) & RT‑4 human urinary bladder transitional cell papilloma cell line (Negative). ST6 Gal Sialyltransferase 1/ST6GAL1 was detected in immersion fixed U266 human myeloma cell line (Positive) & RT‑4 human urinary bladder transitional cell papilloma cell line (Negative) using Goat Anti-Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5924) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to Golgi. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Western Blot Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot ST6Gal-I expression in OV4 ovarian cancer cells. OV4 cells that have no endogenous ST6Gal-I were stably transduced with either empty vector or ST6Gal-I-expressing lentivirus. ST6Gal-I expression was confirmed by immunocytochemistry (A) and immunoblotting (B). ST6Gal-I localization to the Golgi is shown by co-localization with the Golgi marker GM-130 in the ST6Gal-I forced expression line (C) Par = parental; EV = empty vector; ST6 = cells with forced ST6Gal-I expression. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Immunocytochemistry/Immunofluorescence ST6Gal-I expression in OV4 ovarian cancer cells. OV4 cells that have no endogenous ST6Gal-I were stably transduced with either empty vector or ST6Gal-I-expressing lentivirus. ST6Gal-I expression was confirmed by immunocytochemistry (A) and immunoblotting (B). ST6Gal-I localization to the Golgi is shown by co-localization with the Golgi marker GM-130 in the ST6Gal-I forced expression line (C) Par = parental; EV = empty vector; ST6 = cells with forced ST6Gal-I expression. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot Cells that are resistant to cisplatin have upregulated endogenous ST6Gal-I. (A) Pa-1 cells with ST6Gal-I knockdown (sh.ST6) were exposed to cisplatin for 3 weeks, and the remaining viable population (sh.ST6 cis-res) was expanded and immunoblotted for ST6Gal-I. (B) Pa-1 cells with ST6Gal-I knockdown do not upregulate ST6Gal-I expression following a 24-hr treatment with cisplatin (sh.ST6 + cis). (C) Parental A2780 ovarian cancer cells (Par) and a cisplatin-resistant derivative population (Cis-res) were immunoblotted for endogenous ST6Gal-I. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot Cells that are resistant to cisplatin have upregulated endogenous ST6Gal-I. (A) Pa-1 cells with ST6Gal-I knockdown (sh.ST6) were exposed to cisplatin for 3 weeks, and the remaining viable population (sh.ST6 cis-res) was expanded and immunoblotted for ST6Gal-I. (B) Pa-1 cells with ST6Gal-I knockdown do not upregulate ST6Gal-I expression following a 24-hr treatment with cisplatin (sh.ST6 + cis). (C) Parental A2780 ovarian cancer cells (Par) and a cisplatin-resistant derivative population (Cis-res) were immunoblotted for endogenous ST6Gal-I. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot Cells that are resistant to cisplatin have upregulated endogenous ST6Gal-I. (A) Pa-1 cells with ST6Gal-I knockdown (sh.ST6) were exposed to cisplatin for 3 weeks, and the remaining viable population (sh.ST6 cis-res) was expanded and immunoblotted for ST6Gal-I. (B) Pa-1 cells with ST6Gal-I knockdown do not upregulate ST6Gal-I expression following a 24-hr treatment with cisplatin (sh.ST6 + cis). (C) Parental A2780 ovarian cancer cells (Par) and a cisplatin-resistant derivative population (Cis-res) were immunoblotted for endogenous ST6Gal-I. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Immunocytochemistry/Immunofluorescence ST6Gal-I expression in OV4 ovarian cancer cells. OV4 cells that have no endogenous ST6Gal-I were stably transduced with either empty vector or ST6Gal-I-expressing lentivirus. ST6Gal-I expression was confirmed by immunocytochemistry (A) and immunoblotting (B). ST6Gal-I localization to the Golgi is shown by co-localization with the Golgi marker GM-130 in the ST6Gal-I forced expression line (C) Par = parental; EV = empty vector; ST6 = cells with forced ST6Gal-I expression. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Immunocytochemistry/Immunofluorescence ST6Gal-I knockdown in Pa-1 ovarian cancer cells. Pa-1 cells that have high endogenous ST6Gal-I were stably transduced with either empty vector lentivirus, or virus expressing shRNA for ST6Gal-I. ST6Gal-I knockdown was confirmed by immunocytochemistry (A) and immunoblotting (B). ST6Gal-I localization to the Golgi was confirmed by co-localization with the Golgi marker GM-130 in the empty vector transduced line (C) Par = parental; EV = empty vector; sh.ST6 = cells stably expressing shRNA for ST6Gal-I. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot View Larger

Detection of Human ST6 Gal Sialyltransferase 1/ST6GAL1/CD75 by Western Blot ST6Gal-I knockdown in Pa-1 ovarian cancer cells. Pa-1 cells that have high endogenous ST6Gal-I were stably transduced with either empty vector lentivirus, or virus expressing shRNA for ST6Gal-I. ST6Gal-I knockdown was confirmed by immunocytochemistry (A) and immunoblotting (B). ST6Gal-I localization to the Golgi was confirmed by co-localization with the Golgi marker GM-130 in the empty vector transduced line (C) Par = parental; EV = empty vector; sh.ST6 = cells stably expressing shRNA for ST6Gal-I. Image collected and cropped by CiteAb from the following publication (https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-25), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ST6 Gal Sialyltransferase 1/ST6GAL1

Sialic acid molecules attached to glycoproteins or glycosphingolipids play important roles in various biological processes such as immune recognition, pathogen infection, and cell adhesion (1). Sialyltransferases are key enzymes that regulate the cellular levels of sialic acid-containing molecules. Beta-galactosamide alpha‑2,6‑sialyltransferase 1 encoded by the ST6GAL1 gene is a type-II membrane protein localized in the trans-Golgi network and catalyzes 2,6-sialylation of Gal beta 1,4‑GlcNAc structures on N-glycans (2). The enzyme is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB‑6, CD75, and CD76 (3). ST6GAL1 is highly expressed in the liver and also expressed in most other tissues to some extent (4). ST6GAL1 deficiency causes abnormalities in B-cell immunoreactivity (5). The expression and activity of ST6GAL1 are associated with tumor metastasis in breast (6) and colon (7) cancers. The majority of ST6GAL1 in the liver is cleaved and secreted into the serum (8) and may be used as a biomarker for hepatitis diseases (9).

References
  1. Varki, A. et al. (1999) Essentials of Glycobiology, Cold Spring Harbor Laboratory Press, pp195.
  2. Weinstein, J. et al. (1987) J. Biol. Chem. 262:17735.
  3. Bast, B.J. et al. (1992) J. Cell Biol. 116:423.
  4. Kitagawa, H. and J.C. Paulson (1994) J. Biol. Chem. 269:17872.
  5. Hennet, T. et al. (1998) Proc. Natl. Acad. Sci. USA 95:4504.
  6. Recchi, M.A. et al. (1998) Cancer Res. 58:4066.
  7. Dall’Olio, F. et al. (2001) Eur. J. Biochem. 268:5876.
  8. Weinstein, J. et al. (1987) J. Biol. Chem. 262:17735.
  9. Kitazume, S. et al. (2009) Glycobiology 19:479.
Long Name
ST6 beta-Galactoside alpha-2,6-Sialyltransferase 1
Entrez Gene IDs
6480 (Human); 20440 (Mouse); 25197 (Rat)
Alternate Names
Alpha 2,6-ST; B-cell antigen CD75; beta-galactoside alpha-2,6-sialyltransferase 1; CD75; CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; EC 2.4.99.1; MGC48859; sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase); sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); Sialyltransferase 1; SIAT1; SIAT1Alpha 2,6-ST 1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6Gal I; ST6GAL1; ST6GalI; ST6N

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Citations for Human ST6 Gal Sialyltransferase 1/
ST6GAL1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

29 Citations: Showing 1 - 10
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  1. Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
    Authors: Dashzeveg, NK;Jia, Y;Zhang, Y;Gerratana, L;Patel, P;Shajahan, A;Dandar, T;Ramos, EK;Almubarak, HF;Adorno-Cruz, V;Taftaf, R;Schuster, EJ;Scholten, D;Sokolowski, MT;Reduzzi, C;El-Shennawy, L;Hoffmann, AD;Manai, M;Zhang, Q;D'Amico, P;Azadi, P;Colley, KJ;Platanias, LC;Shah, AN;Gradishar, WJ;Cristofanilli, M;Muller, WA;Cobb, BA;Liu, H;
    Cancer discovery
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface
    Authors: X Zou, J Lu, Y Deng, Q Liu, X Yan, Y Cui, X Xiao, M Fang, F Yang, H Sawaki, T Sato, B Tan, X Lu, B Feng, A Kuno, H Narimatsu, C Gao, Y Zhang
    Oncogene, 2022-12-17;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees
    Authors: J Van Coilli, T Pongracz, J Rahmöller, HJ Chen, CE Geyer, LA van Vught, JS Buhre, T Šušti?, TLJ van Osch, M Steenhuis, W Hoepel, W Wang, AS Lixenfeld, J Nouta, S Keijzer, F Linty, R Visser, MD Larsen, EL Martin, I Künsting, S Lehrian, V von Kopylo, C Kern, HB Lunding, M de Winther, N van Mourik, T Rispens, T Graf, MA Slim, RP Minnaar, MK Bomers, JJ Sikkens, APJ Vlaar, CE van der Sc, J den Dunnen, M Wuhrer, M Ehlers, G Vidarsson, Fatebenefr, UMC COVID-
    EBioMedicine, 2022-12-16;87(0):104408.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Deficiency in ST6GAL1, one of the two alpha 2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease
    Authors: Natallia Makarava, Elizaveta Katorcha, Jennifer Chen-Yu Chang, Joseph T. Y. Lau, Ilia V. Baskakov
    Frontiers in Molecular Biosciences
  5. alpha2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth
    Authors: S Gc, K Tuy, L Rickenback, R Jones, A Chakrabort, CR Miller, EA Beierle, VS Hanumanthu, AN Tran, JA Mobley, SL Bellis, AB Hjelmeland
    JCI Insight, 2022-11-08;7(21):.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  6. Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness
    Authors: NC Hait, A Maiti, R Wu, VL Andersen, CC Hsu, Y Wu, DG Chapla, K Takabe, ME Rusiniak, W Bshara, J Zhang, KW Moremen, JTY Lau
    Cancer Gene Therapy, 2022-06-08;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Multi-Faceted Effects of ST6Gal1 Expression on Precursor B-Lineage Acute Lymphoblastic Leukemia
    Authors: Mingfeng Zhang, Tong Qi, Lu Yang, Daniel Kolarich, Nora Heisterkamp
    Frontiers in Oncology
  8. Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer
    Authors: M Smithson, R Irwin, G Williams, KL Alexander, LE Smythies, M Nearing, MC McLeod, S Al Diffalh, SL Bellis, KM Hardiman
    The Journal of Biological Chemistry, 2022-01-15;0(0):101594.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  9. Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells
    Authors: CM Britain, N Bhalerao, AD Silva, A Chakrabort, DJ Buchsbaum, MR Crowley, DK Crossman, YJK Edwards, SL Bellis
    J Biol Chem, 2020-11-23;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase
    Authors: AT Holdbrooks, KE Ankenbauer, J Hwang, SL Bellis
    PLoS ONE, 2020-11-09;15(11):e0241850.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  11. Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover
    Authors: KL Alexander, CA Serrano, A Chakrabort, M Nearing, LN Council, A Riquelme, M Garrido, SL Bellis, LE Smythies, PD Smith
    J. Biol. Chem., 2020-08-06;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: ICC, IHC
  12. Sialylation of FGFR1 by ST6Gal?I overexpression contributes to ovarian cancer cell migration and chemoresistance
    Authors: L Ou, X He, N Liu, Y Song, J Li, L Gao, X Huang, Z Deng, X Wang, S Lin
    Mol Med Rep, 2020-01-20;21(3):1449-1460.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  13. Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells
    Authors: KA Dorsett, RB Jones, KE Ankenbauer, AB Hjelmeland, SL Bellis
    J Ovarian Res, 2019-10-14;12(1):93.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  14. Transfer of Functional Cargo in Exomeres
    Authors: Q Zhang, JN Higginboth, DK Jeppesen, YP Yang, W Li, ET McKinley, R Graves-Dea, J Ping, CM Britain, KA Dorsett, CL Hartman, DA Ford, RM Allen, KC Vickers, Q Liu, JL Franklin, SL Bellis, RJ Coffey
    Cell Rep, 2019-04-04;0(0):.
    Species: Human
    Sample Types: Exosomes
    Applications: Western Blot
  15. Unravelling the Role of O-glycans in Influenza A Virus Infection
    Authors: J Mayr, K Lau, JCC Lai, IA Gagarinov, Y Shi, S McAtamney, RWY Chan, J Nicholls, M von Itzste, T Haselhorst
    Sci Rep, 2018-11-06;8(1):16382.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  16. Glycoengineering design options for IgG1 in CHO cells using precise gene editing
    Authors: MA Schulz, W Tian, Y Mao, J Van Coilli, L Sun, JS Larsen, YH Chen, C Kristensen, SY Vakhrushev, H Clausen, Z Yang
    Glycobiology, 2018-07-01;0(0):.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: ICC
  17. The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling
    Authors: RB Jones, KA Dorsett, AB Hjelmeland, SL Bellis
    J. Biol. Chem., 2018-02-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot
  18. Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death
    Authors: CM Britain, AT Holdbrooks, JC Anderson, CD Willey, SL Bellis
    J Ovarian Res, 2018-02-05;11(1):12.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  19. ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor
    Authors: AT Holdbrooks, CM Britain, SL Bellis
    J. Biol. Chem., 2017-12-12;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  20. ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage
    Authors: A Chakrabort, KA Dorsett, HQ Trummell, ES Yang, PG Oliver, JA Bonner, DJ Buchsbaum, SL Bellis
    J. Biol. Chem., 2017-11-30;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  21. B-cell-independent sialylation of IgG
    Authors: Mark B Jones
    Proc Natl Acad Sci USA, 2016-06-14;113(26):7207-12.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  22. The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype
    Cancer Res, 2016-05-23;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Western Blot
  23. Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells
    Authors: Yu-Chieh Wang, Jason W. Stein, Candace L. Lynch, Ha T. Tran, Chia-Yao Lee, Ronald Coleman et al.
    Scientific Reports
  24. Sialylation by beta -galactoside alpha -2,6-sialyltransferase and N-glycans regulate cell adhesion and invasion in human anaplastic large cell lymphoma
    Authors: OSAMU SUZUKI, MASAFUMI ABE, YUKO HASHIMOTO
    International Journal of Oncology
  25. Galectin-1-mediated cell adhesion, invasion and cell death in human anaplastic large cell lymphoma: regulatory roles of cell surface glycans.
    Authors: Suzuki O, Abe M
    Int J Oncol, 2014-03-04;44(5):1433-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  26. Treatment Response in Kawasaki Disease Is Associated with Sialylation Levels of Endogenous but Not Therapeutic Intravenous Immunoglobulin G
    Authors: Shohei Ogata, Chisato Shimizu, Alessandra Franco, Ranim Touma, John T. Kanegaye, Biswa P. Choudhury et al.
    PLoS ONE
  27. ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells.
    Authors: Schultz, Matthew, Swindall, Amanda F, Wright, John W, Sztul, Elizabet, Landen, Charles, Bellis, Susan L
    J Ovarian Res, 2013-04-11;6(1):25.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  28. ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell lines.
    Authors: Swindall A, Londono-Joshi A, Schultz M, Fineberg N, Buchsbaum D, Bellis S
    Cancer Res, 2013-01-28;73(7):2368-78.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: IHC, Western Blot
  29. Sialylation of MUC4b N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with Type-2 inflammation
    Authors: Zhou X, Kinlough CL, Hughey RP et al.
    JCI Insight

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Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antibody
By Paul Stabach on 03/21/2018
Application: Immunocytochemistry/Immunofluorescence Sample Tested: ST6GAL1 transfected CHO cells Species: Mouse

Used this Ab for both Western and immunofluorescence on mouse ST6GAL1 transfected CHO cells. Fixed cells with 4% Paraformaldehyde and permeabilized with 0.5% saponin.