Human TR4/NR2C2 Antibody

Catalog # Availability Size / Price Qty
PP-H0107B-00
Product Details
Citations (1)
FAQs
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Human TR4/NR2C2 Antibody Summary

Species Reactivity
Human
Specificity
This antibody specifically recognizes human TR4 and cross-reacts with mouse and rat TR4. Not yet tested in other species.
Source
Monoclonal Mouse IgG2A Clone # H0107B
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Recombinant human TR4/NR2C2
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
This antibody can be used at 2 μg/mL with the appropriatesecondary reagents to detect human TR4.
 
Immunohistochemistry
This antibody can be used at 10 μg/mL with theappropriate secondary reagents to detect human TR4.
 
Immunoprecipitation
Optimal dilutions should be determined by eachlaboratory.
 
Direct ELISA
This antibody can be used at 0.1 μg/mL with the appropriatesecondary reagents to detect human TR4.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: TR4/NR2C2

Human Testicular Receptor 4 (TR4, TAK1; NR2C2) is a member of the Orphan Nuclear Receptor family. TR4 was originally cloned from lymphoblastoma Raji cells or mouse brain cDNA library. No ligand has been reported. Northern blot shows TR4 is transcribed as a 9 kb mRNA in many tissues and as a 2.8 kb mRNA in testis, mainly in spermatocytes. TR4 has two isoforms called TR4 alpha 1 and TR4 alpha 2 that differ in 19 amino acids coded by two separate exons. Both products translated from the 9 kb transcript are ubiquitously expressed. Since TR4 binds to the same elements for the RAR-RXR or TR-RXR heterodimers, TR4 may have an inhibitory effect for retinoic acid-mediated transactivation.

Long Name
Testicular Orphan Nuclear Receptor 4
Entrez Gene IDs
7182 (Human)
Alternate Names
hTAK1; NR2C2; Nuclear hormone receptor TR4; nuclear receptor subfamily 2 group C member 2; nuclear receptor subfamily 2, group C, member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; TAK1; TAK1TR4TR2R1; Testicular receptor 4; TR4 nuclear hormone receptor; TR4

Product Datasheets

Citation for Human TR4/NR2C2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.
    Authors: Ding X, Yang D, Xia L, Chen B, Yu S, Niu Y, Wang M, Li G, Chang C
    Mol Cancer, 2015;14(0):16.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P

FAQs

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Cell and Tissue Staining Kits

ExactaChIP Chromatin Immunoprecipitation Kits

Immunohistochemistry Reagents

Isotype Controls

Mouse IgG2A Isotype Control

Secondary Antibodies

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