Human TR4/NR2C2 Antibody

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Product Details
Citations (1)
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Human TR4/NR2C2 Antibody Summary

Species Reactivity
This antibody specifically recognizes human TR4 and cross-reacts with mouse and rat TR4. Not yet tested in other species.
Monoclonal Mouse IgG2A Clone # H0107B
Protein A or G purified from hybridoma culture supernatant
Recombinant human TR4/NR2C2
A liquid formulation in physiologic saline with 0.1% NaN3.

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Recommended Concentration
Western Blot
This antibody can be used at 2 μg/mL with the appropriatesecondary reagents to detect human TR4.
This antibody can be used at 10 μg/mL with theappropriate secondary reagents to detect human TR4.
Optimal dilutions should be determined by eachlaboratory.
Direct ELISA
This antibody can be used at 0.1 μg/mL with the appropriatesecondary reagents to detect human TR4.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: TR4/NR2C2

Human Testicular Receptor 4 (TR4, TAK1; NR2C2) is a member of the Orphan Nuclear Receptor family. TR4 was originally cloned from lymphoblastoma Raji cells or mouse brain cDNA library. No ligand has been reported. Northern blot shows TR4 is transcribed as a 9 kb mRNA in many tissues and as a 2.8 kb mRNA in testis, mainly in spermatocytes. TR4 has two isoforms called TR4 alpha 1 and TR4 alpha 2 that differ in 19 amino acids coded by two separate exons. Both products translated from the 9 kb transcript are ubiquitously expressed. Since TR4 binds to the same elements for the RAR-RXR or TR-RXR heterodimers, TR4 may have an inhibitory effect for retinoic acid-mediated transactivation.

Long Name
Testicular Orphan Nuclear Receptor 4
Entrez Gene IDs
7182 (Human)
Alternate Names
hTAK1; NR2C2; Nuclear hormone receptor TR4; nuclear receptor subfamily 2 group C member 2; nuclear receptor subfamily 2, group C, member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; TAK1; TAK1TR4TR2R1; Testicular receptor 4; TR4 nuclear hormone receptor; TR4

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Citation for Human TR4/NR2C2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.
    Authors: Ding X, Yang D, Xia L, Chen B, Yu S, Niu Y, Wang M, Li G, Chang C
    Mol Cancer, 2015;14(0):16.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P


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Isotype Controls

Mouse IgG2A Isotype Control

Secondary Antibodies

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