Human TR4/NR2C2 Antibody
Human TR4/NR2C2 Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Human Testicular Receptor 4 (TR4, TAK1; NR2C2) is a member of the Orphan Nuclear Receptor family. TR4 was originally cloned from lymphoblastoma Raji cells or mouse brain cDNA library. No ligand has been reported. Northern blot shows TR4 is transcribed as a 9 kb mRNA in many tissues and as a 2.8 kb mRNA in testis, mainly in spermatocytes. TR4 has two isoforms called TR4 alpha 1 and TR4 alpha 2 that differ in 19 amino acids coded by two separate exons. Both products translated from the 9 kb transcript are ubiquitously expressed. Since TR4 binds to the same elements for the RAR-RXR or TR-RXR heterodimers, TR4 may have an inhibitory effect for retinoic acid-mediated transactivation.
Citation for Human TR4/NR2C2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals.
Authors: Ding X, Yang D, Xia L, Chen B, Yu S, Niu Y, Wang M, Li G, Chang C
Mol Cancer, 2015;14(0):16.
Sample Types: Whole Tissue
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Cell and Tissue Staining Kits
ExactaChIP Chromatin Immunoprecipitation Kits
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