Cancer Immunotherapy: Cancer Vaccines
Cancer vaccines are typically prepared with antigen presenting cells such as plasmacytoid or myeloid dendritic cells (DC). Tumor associated antigens (TAA) can be derived from whole tumor cells, tumor cell lysates, or synthetic peptides from tumor lysates. DC are pulsed with the TAA which are presented on the DC surface in complex with MHC molecules. Alternatively, DC can be transduced with a vector encoding the TAA. DC presenting tumor-specific antigens can trigger tumor-specific cytotoxic NK and CD8+ T cells, leading to tumor regression.
DC Isolation/Expansion
Begin your DC-based vaccine protocol with the best possible preparation of dendritic cells. Characterize your cells thoroughly to make sure you have the ones you want.
Dendritic Cell Subsets
Multiple subsets of dendritic cells are distinguished by phenotype and function. They may exhibit distinct effectiveness when used as the base of a cancer vaccine in different settings.
Immunogenic Cell Death
ICD refers to cell death other than controlled apoptotic cell death. It results in the exposure of normally intracellular molecules to the immune system, leading to an inflammatory reaction.
Antigen Presentation
Tumor-specific immune responses are enhanced by the internalization, processing, and presentation of tumor-associated antigens by dendritic cells. Take a look through our products for antigen presentation research.
Cancer Immunotherapy Research brochure
Dendritic Cells brochure
Dendritic Cells research area
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