Compounds for ESC/iPSC Proliferation and Renewal: Products

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Y-27632 synthesized to cGMP guidelines

Selective inhibitor of TGF-βRI, ALK4 and ALK7

PORCN inhibitor; inhibits Wnt processing and secretion

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

MEK inhibitor

Potent AMPK activator

Potent, selective GSK-3 inhibitor

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Potent GSK-3 inhibitor; also inhibits cdks

Potent pan-caspase inhibitor

Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Potent and selective Lck and Src inhibitor; also inhibits SIK

Enhances survival of human ESCs following enzymatic dissociation

STAT3 inhibitor; also blocks cancer stem cell self-renewal

Heparin sulfate antagonist

Sterile-filtered 10 mM solution of Y-27632 pre-dissolved in water

Cell culture supplement for improving stem cell survival

Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds