16 results for "Small G Protein Inhibitors Small Molecules and Peptides" in Products
Small G Protein Inhibitors Small Molecules and Peptides
Like Gα proteins, small GTPases alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP) and so function as binary switches that regulate cytosolic signaling pathways. GDP/GTP cycling is controlled by two types of regulatory proteins that associate with small GTPases. Guanine exchange factors (GEFs) promote the formation of the active, GTP bound form of RAS proteins while GTPase activating proteins (GAPs) accelerate GTPase activity, promoting the inactive, GDP bound form.
Selective inhibitor of Rac1-GEF interaction; antioncogenic
| Chemical Name: | N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride |
| Purity: | ≥98% |
Potent Rac family inhibitor
| Chemical Name: | 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride |
| Purity: | ≥98% |
Selective Cdc42 Rho family inhibitor
| Alternate Names: | CID 2950007 |
| Chemical Name: | 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide |
| Purity: | ≥98% |
DOCK2-Rac1 interaction inhibitor
| Chemical Name: | 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
| Purity: | ≥98% |
Epac inhibitor
| Chemical Name: | α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile |
| Purity: | ≥98% |
Rho inhibitor
| Chemical Name: | D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride |
| Purity: | ≥98% |
Potent farnesyl diphosphate (FPP) synthase inhibitor
| Alternate Names: | Zometa |
| Chemical Name: | [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid |
| Purity: | ≥98% |
Cdc42 inhibitor
| Chemical Name: | 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol |
| Purity: | ≥98% |
Sec7-specific GEF inhibitor; selective for cytohesin family
| Chemical Name: | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide |
| Purity: | ≥98% |
Selective ARF6 inhibitor
| Chemical Name: | 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| Purity: | ≥98% |
ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
| Chemical Name: | (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol |
| Purity: | ≥98% |
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
| Chemical Name: | 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride |
| Purity: | ≥98% |
Ras signaling inhibitor; inhibits Ack1 and GCK
| Chemical Name: | N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Purity: | ≥98% |
Selective Epac2 inhibitor
| Chemical Name: | 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole |
| Purity: | ≥98% |
Rac inhibitor
| Chemical Name: | N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine |
| Purity: | ≥98% |
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
| Chemical Name: | [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone |
| Purity: | ≥98% |
