Human CART aa 28-116 Antibody
Human CART aa 28-116 Antibody Summary
Ala37-Leu116
Accession # Q16568
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CART
CART, also known as cocaine and amphetamine-related transcript, is a 10 kDa secreted polypeptide produced by neuronal cell types in a variety of locations. In human, the molecule is synthesized as a 116 amino acid (aa) precursor with a 27 aa signal sequence an 89 aa mature segment. There are six C-terminal cysteines that form three intrachain disulfide bonds, and the potential exists for both sulfation and phosphorylation in the N-terminal region. There are numerous monobasic and dibasic sites for enzyme cleavage, and multiple, presumably proteolytically-generated short forms are known to exist. These include a 5K, 48 aa peptide (CART 42‑89), and a 4.3K, 40 aa peptide (CART 49-89). Human CART is 98% aa identical to both moyuse and rat CART (1-89). Although CART suppresses feeding and increases pain tolerance, there would appear to be differences between the various forms of CART on other functions. In addition, anatomical location is associated with differing lengths of CART. For example, 89 aa and 79 aa forms are found in the adrenal, while 48 aa and 44 aa forms are found in the hypothalamus.
- Douglass, J. & S. Daoud (1996) Gene 169:241.
- Douglass, J. et al. (1995) J. Neurosci. 15:247.
- Adams, L.D. et al. (1999) Brain Res. 848:137.
- Thim, L. et al. (1999) Proc. Natl. Acad. Sci. USA 96:2722.
- Bannon, A.W. et al. (2001) J. Pharmacol. Exp. Ther. 299:1021.
- Kuhar, M.J. & L.L. Yoho (1999) Synapse 33:163.
- Thim, L. et al. (1998) FEBS Lett. 428:263.
Product Datasheets
Citations for Human CART aa 28-116 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus
Authors: L Rytel, S Gonkowski
Int J Mol Sci, 2020;21(12):.
Species: Porcine
Sample Types: Whole Tissue
Applications: IHC -
Neurochemical characteristics of calbindin-like immunoreactive coeliac-cranial mesenteric ganglion complex (CCMG) neurons supplying the pre-pyloric region of the porcine stomach
Authors: K Palus, M Bulc, M Czajkowska, B Mici?ski, J Ca?ka
Tissue Cell, 2018;50(0):8-14.
Species: Porcine
Sample Types: Whole Cells
Applications: ICC -
Cocaine- and amphetamine-regulated transcript peptide and calcium binding proteins immunoreactivity in the superficial layers of the superior colliculus in the guinea pig: Implications for visual sensory processing
Authors: Janusz Najdzion
J. Chem. Neuroanat, 2016;79(0):66-79.
Species: Guinea Pig
Sample Types: Whole Tissue
Applications: IHC -
Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit.
Authors: Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss A, Hucho T
PLoS ONE, 2014;9(12):e115731.
Species: Rat
Sample Types: Whole Cells
Applications: IHC-Fr -
Chemical coding for cardiovascular sympathetic preganglionic neurons in rats.
Authors: Gonsalvez DG, Kerman IA, McAllen RM
J. Neurosci., 2010;30(35):11781-91.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-Fr
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