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Human CD68/SR-D1 Antibody

Catalog #: MAB20401
18 Citations 1 Review Datasheet / COA / SDS
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MAB20401
MAB20401-SP

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Detection of CD68/SR‑D1 in Human Liver.
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Citations (18)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CD68/SR-D1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human CD68/SR‑D1 in direct ELISAs.
Source
Monoclonal Mouse IgG2B Clone # 298807
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human CD68/SR‑D1
Asn22-Ile320
Accession # AAB25811
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
0.1-10 µg/mL
Immersion fixed paraffin-embedded sections of human liver

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry View Larger

Detection of CD68/SR‑D1 in Human Liver. CD68/SR‑D1 was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human CD68/SR‑D1 Monoclonal Antibody (Catalog # MAB20401) at 0.1 µg/ml for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001) or the HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cell surface of Kupffer cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CD68/SR-D1

CD68, also called Scavenger Receptor D1 (SR-D1), is a type I transmembrane glycoprotein that belongs to the LAMP family of molecules. CD68 is expressed on monocytes and macrophages and serves as a scavenger receptor for oxidized LDL.

Entrez Gene IDs
968 (Human); 12514 (Mouse); 287435 (Rat)
Alternate Names
CD_antigen: CD68; CD68 antigen; CD68 molecule; CD68; DKFZp686M18236; gp110; LAMP4; macrophage antigen CD68; Macrosialin; SCARD1; scavenger receptor class D, member 1; SRD1; SR-D1

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Citations for Human CD68/SR-D1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

18 Citations: Showing 1 - 10
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  1. Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB
    Authors: Belgiovine, C;Digifico, E;Erreni, M;Putignano, AR;Mannarino, L;Valentino, S;Grizzi, F;Pasqualini, F;Recordati, C;Bertola, L;Zucali, P;Pistillo, D;Paleari, V;Mantovani, A;D'Incalci, M;Marchesi, F;Allavena, P;
    Journal of translational medicine
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. Galectin-9 as a new biomarker of acute-on-chronic liver failure
    Authors: Ling, J;You, S;Chen, W;Yang, X;Xv, Y;Zhu, B;
    Scientific reports
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  3. Impact of Enzymatically Extracted High Molecular Weight Fucoidan on Lipopolysaccharide-Induced Endothelial Activation and Leukocyte Adhesion
    Authors: Kirsten, N;Ohmes, J;Mikkelsen, MD;Nguyen, TT;Blümel, M;Wang, F;Tasdemir, D;Seekamp, A;Meyer, AS;Fuchs, S;
    Marine drugs
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  4. CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages
    Authors: Gillan, JL;Chokshi, M;Hardisty, GR;Clohisey Hendry, S;Prasca-Chamorro, D;Robinson, NJ;Lasota, B;Clark, R;Murphy, L;Whyte, MKB;Baillie, JK;Davidson, DJ;Bao, G;Gray, RD;
    Science advances
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  5. S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
    Authors: F Real, A Zhu, B Huang, A Belmellat, A Sennepin, T Vogl, C Ransy, M Revol, R Arrigucci, A Lombès, J Roth, ML Gennaro, F Bouillaud, S Cristofari, M Bomsel
    Nature Communications, 2022-10-11;13(1):5956.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infection
    Authors: Emilia Barreto-Duran, Artur Szczepański, Adrianna Gałuszka-Bulaga, Marcin Surmiak, Maciej Siedlar, Marek Sanak et al.
    Frontiers in Immunology
  7. Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection
    Authors: RM Gopalakris, M Aid, NB Mercado, C Davis, S Malik, E Geiger, V Varner, R Jones, SE Bosinger, C Piedra-Mor, AJ Martinot, DH Barouch, RK Reeves, CS Tan
    JCI Insight, 2021-10-22;6(20):.
    Species: Primate
    Sample Types: Whole Tissue
    Applications: IHC
  8. Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response
    Authors: Z Feng, J Zhou, Y Liu, R Xia, Q Li, L Yan, Q Chen, X Chen, Y Jiang, G Chao, M Wang, G Zhou, Y Zhang, Y Wang, H Xia
    Cell Death and Differentiation, 2021-03-22;0(0):.
    Species: Human, Mouse
    Sample Types: Protein
    Applications: ELISA Control
  9. Thrombospondin‑2 is upregulated in patients with aortic dissection and enhances angiotensin II‑induced smooth muscle cell apoptosis
    Authors: Liping Qi, Kui Wu, Shutian Shi, Qingwei Ji, Huangtai Miao, Que Bin
    Experimental and Therapeutic Medicine
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  10. Response gene to complement 32 expression in macrophages augments paracrine stimulation-mediated colon cancer progression
    Authors: P Zhao, B Wang, Z Zhang, W Zhang, Y Liu
    Cell Death Dis, 2019-10-10;10(10):776.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  11. Bordetella Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells
    Authors: JN Ahmad, J Holubova, O Benada, O Kofronova, L Stehlik, M Vasakova, P Sebo
    MBio, 2019-09-24;10(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot
  12. Impact of heat therapy on recovery after eccentric exercise in humans
    Authors: Kyoungrae Kim, Shihuan Kuang, Qifan Song, Timothy P. Gavin, Bruno T. Roseguini
    Journal of Applied Physiology
  13. Autophagy Is an Innate Mechanism Associated with Leprosy Polarization
    Authors: BJ Silva, MG Barbosa, PR Andrade, H Ferreira, JA Nery, S C“rte-Real, GM da Silva, PS Rosa, M Fabri, EN Sarno, RO Pinheiro
    PLoS Pathog, 2017-01-05;13(1):e1006103.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  14. Association between PON1 rs662 polymorphism and coronary artery disease.
    Authors: Liu T, Zhang X, Zhang J, Liang Z, Cai W, Huang M, Yan C, Zhu Z, Han Y
    Eur J Clin Nutr, 2014-06-11;68(9):1029-35.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  15. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema.
    Authors: Shan M, Cheng HF, Song LZ
    Sci Transl Med, 2009-10-28;1(4):4ra10.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  16. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy.
    Authors: Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, Levy DE, Xiong H, Chen N, He JC
    Kidney Int., 2009-04-08;76(1):63-71.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  17. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity.
    Authors: Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR
    Diabetes, 2007-01-01;56(1):16-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  18. Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor.
    Authors: Yang SY, Nasser S, Markel DC, Robbins PD, Wooley PH
    J Bone Joint Surg Am, 2005-05-01;87(5):1088-97.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC

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Human CD68/SR-D1 Antibody
By Anonymous on 05/03/2017
Application: IHC Sample Tested: Adult lung Species: Human
Immunohistochemistry Human CD68/SR-D1 Antibody MAB20401