Human CXCL14/BRAK Antibody
Human CXCL14/BRAK Antibody Summary
Accession # O95715
Human CXCL14/BRAK Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CXCL14/BRAK (breast and kidney-expressed chemokine), also named MIP-2 gamma, KEC (kidney-expressed chemokine), and BMAC (B cell and monocyte-activating chemokine), is a member of CXC chemokine superfamily (1 - 5). The deduced 99 amino acid (aa) residue precursor has a 22 aa putative signal peptide that is cleaved to produce the 77 aa mature protein. Mature human and mouse CXCL14 differ by only 2 residues. Human CXCL14 shares approximately 30% aa sequence identity with MIP-2 alpha (GRO beta ) as well as MIP-2 beta (GRO gamma ). The gene for CXCL14 has been mapped human chromosome 5q31. Unlike the MIP-2 chemokines, CXCL14 lacks the ELR domain preceding the CXC motif. CXCL14 transcripts are constitutively expressed at high levels in the basal layer of epidermal keratinocytes and dermal fibroblasts of skin tissues as well as lamina propria cells in normal intestinal tissues. CXCL14 has been shown to be a highly selective chemoattractant for monocytes that have been treated with prostaglandin E2 or forskolin, agents that activate adenylate cyclase. CXCL14 has been proposed to be important for regulating the trafficking of macrophage precursor to regions in skin and mucosal tissues that support their development. Consistent with this hypothesis, macrophages were frequently found to co-localize with CXCL14-producing cells in the dermis and lamina propria.
- Hromas, R. et al. (1999) Biochem. Biophys. Res. Commun. 255:703.
- Cao, X. et al. (2000) J. Immunol. 165:2588.
- Kurth, I. et al. (2001) J. Exp., Med. 194:855.
- Frederick, M.J. et al. (2000) Am. J. Pathol. 156:1937.
- Sleeman, M.A. et al. (2000) Int. Immunol. 12:677.
Citations for Human CXCL14/BRAK Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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The Expression of the Chemokine CXCL14 Correlates with Several Aggressive Aspects of Glioblastoma and Promotes Key Properties of Glioblastoma Cells
Authors: B Fazi, C Proserpio, S Galardi, F Annesi, M Cola, A Mangiola, A Michienzi, SA Ciafrè
Int J Mol Sci, 2019;20(10):.
Sample Types: Cell Lysates
Applications: Western Blot
Involvement of CXCL14 in osteolytic bone metastasis from lung cancer.
Authors: Takiguchi S, Korenaga N, Inoue K, Sugi E, Kataoka Y, Matsusue K, Futagami K, Li Y, Kukita T, Teramoto N, Iguchi H
Int J Oncol, 2014;44(4):1316-24.
Sample Types: Whole Tissue
Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo.
Authors: Shurin GV, Ferris RL, Ferris R, Tourkova IL, Perez L, Lokshin A, Balkir L, Collins B, Chatta GS, Shurin MR
J. Immunol., 2005;174(9):5490-8.
Sample Types: Cell Culture Supernates
Applications: Western Blot
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