Human IL-17RB Antibody
Human IL-17RB Antibody Summary
Accession # Q9NRM6
Human IL-17 RB Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
interleukin 17 (IL-17) family of cytokines, comprising six members
(IL-17, IL-17B through IL-17F), are structurally related proteins with a
conserved cysteine-knot structure. These proinflammatory cytokines can
induce local cytokine productions and are involved in the regulation of
the immune response. The cognate receptors activated by some of these
cytokines have been identified (1). Interleukin-17 B Receptor (IL-17
RB), also known as IL-17Rh1, IL-17ER and EVI27, represents the second
receptor of the IL-17 family of cytokines to be recognized (2-4). Human
IL-17 RB cDNA encodes a 502 amino acid (aa) residue type I membrane
protein with a putative 17 aa signal peptide, a 275 aa extracellular
domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail. By
alternative splicing, a secreted variant of IL-17 RB has also been
identified (4). Human and mouse IIL-17 RB share 76% aa sequence
identity. The human IL-17 RB protein sequence is only 19.2% identical to
the human IL-17 R sequence, but the two receptors share many conserved
cysteine residues within their extracellular domains as well as
additional conserved elements within their cytoplasmic domains. Three
additional type I transmembrane receptors with homology to IL-17 R have
been reported, increasing the number of the IL-17 R family members to
five (5, 6). By Northern blot analysis, human IL-17 RB is highly
expressed in kidneys and liver but is expressed at lower levels in
testes, brain, small intestine and other endocrine tissues (2-4). The
expression of IL-17 RB is significantly up-regulated under inflammatory
IL-17 RB binds strongly to IL-17E and weakly to IL-17B. It does not bind IL-17, IL-17C, and IL-17F. Activation of IL-17 RB by its ligands results in the activation of nuclear factor kappa-B (2-4).
- Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1.
- Shi Y, et al. (2000) J. Biol. Chem. 275:19167.
- Lee, J, et al. (2001) J. Biol. Chem. 276:1660.
- Tian E, et al. (2000) Oncogene 19:2098.
- Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
- Hurst, S.D. et al. (2002) J. Immunol. 169:443.
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