Porcine IL-2 Antibody
Porcine IL-2 Antibody Summary
Accession # P26891
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Interleukin 2 was initially identified as a T cell growth factor that is produced by T cells following activation by mitogens or antigens. Since then, it has been shown that in addition to its T cell growth factor activity, IL-2 can also stimulate the growth and differentiation of B cells, natural killer (NK) cells, lymphocyte activated killer (LAK) cells, monocytes/macrophages and oligodendrocytes. Mature porcine and human IL-2 share approximately 72% amino acid sequence identity.The biological activity of IL-2 is mediated by the binding of IL-2 to cell surface receptor complexes. The functional high-affinity receptor of IL-2 is composed of three distinct polypeptide chains, the IL-2 receptor alpha, beta and gamma subunits. The intermediate-affinity IL-2 receptor complex, which lacks the alpha subunit, but contains both the beta and gamma subunits, is also capable of transducing the IL-2 signal. In T cells, the beta and gamma subunits are shared with the IL-15 receptor complex. The gamma chain of the IL-2 receptor complex is also a subunit of IL-4, IL-7, and IL-9 receptor complexes.
- Taniguchi, T. and Y. Minami (1993) Cell 73:5.
- Waldmann, T. et al. (1998) Int. Rev. Immunol. 16:205.
- Nelson, B.H. and D.M. Willeford (1998) Adv. Immunol. 70:1.
Citation for Porcine IL-2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
In vitro effect of vitamin E on lectin-stimulated porcine peripheral blood mononuclear cells.
Authors: Hernandez J, Soto-Canevett E, Pinelli-Saavedra A, Resendiz M, Moya-Camarena SY, Klasing KC
Vet. Immunol. Immunopathol., 2009;131(1):9-16.
Sample Types: Whole Cells
Applications: Flow Cytometry
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