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18 results for "Autophagy Activators Small Molecules and Peptides" in Products

Autophagy Activators Small Molecules and Peptides

Autophagy is a process by which a cell breaks down macromolecules in response to starvation or stress signals. While it is closely linked with apoptosis, autophagy is primarily characterized as a catabolic mechanism by which cellular energy homeostasis is maintained, and by which cellular organelles and proteins are degraded.

Autophagy also occurs in response to similar stresses to those which induce apoptosis and several proapoptotic signals also induce autophagy - for example, ...

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Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternate Names: Compound C,BML-275
Chemical Name: 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Purity: ≥98%
Potent AMPK inhibitor; also BMP type I receptor inhibitor
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Potent and selective mTOR inhibitor

Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity: ≥98%
Potent and selective mTOR inhibitor
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Potent inhibitor of SERCA ATPase

Chemical Name: (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Purity: ≥97%
Potent inhibitor of SERCA ATPase
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mTOR inhibitor; immunosuppressant

Chemical Name: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Purity: ≥98%
mTOR inhibitor; immunosuppressant
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mTOR inhibitor; Immunosuppressant

Alternate Names: RAD001
Chemical Name: 42-O-(2-Hydroxyethyl)rapamycin
Purity: ≥98%
mTOR inhibitor; Immunosuppressant
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STAT3 inhibitor; also inhibits mTORC1 signaling

Chemical Name: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Purity: ≥98%
STAT3 inhibitor; also inhibits mTORC1 signaling
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Histone deacetylase inhibitor

Alternate Names: VPA,Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Histone deacetylase inhibitor
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Antibiotic; GlcNAc phosphotransferase inhibitor

Chemical Name: Tunicamycin from Streptomyces sp.
Purity: ≥98%
Antibiotic; GlcNAc phosphotransferase inhibitor
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Potent histone deacetylase inhibitor

Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity: ≥95%
Potent histone deacetylase inhibitor
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Class I and II HDAC inhibitor

Alternate Names: Vorinostat
Chemical Name: N-Hydroxy-N'-phenyloctanediamide
Purity: ≥98%
Class I and II HDAC inhibitor
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Potent and selective mTOR inhibitor

Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity: ≥98%
Potent and selective mTOR inhibitor
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Inositol monophosphatase inhibitor

Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Inositol monophosphatase inhibitor
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Cyclooxygenase inhibitor

Chemical Name: 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
Purity: ≥98%
Cyclooxygenase inhibitor
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PKB/Akt inhibitor; also modulates Kv2.1 current

Alternate Names: KRX-0401
Chemical Name: Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate
Purity: ≥98%
PKB/Akt inhibitor; also modulates Kv2.1 current
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Reported PKCδ inhibitor

Chemical Name: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Purity: ≥95%
Reported PKCδ inhibitor
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mTOR inhibitor; antitumor

Alternate Names: CCI-779
Chemical Name: Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
Purity: ≥98%
mTOR inhibitor; antitumor
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High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Chemical Name: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Purity: ≥98%
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
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Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

Chemical Name: (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide
Purity: ≥98%
Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
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