135 results for "mGluR5" in Products
mGluR5 Products
Human metabotropic glutamate receptor 5 (mGluR5; also mGluR5b) is a 150 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. mGluR5 is constitutively expressed and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length and contains an extracellular domain (ECD) of 558 amino acids. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca2+-sensor receptor. There is one alternate splice form (mGluR5a) that shows a 32 aa deletion between aa 877 - 908 in the cytoplasmic tail. Over aa 19 - 509, human mGluR5 is 98% aa identical to mouse, rat, and canine mGluR5.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #464818 |
| Applications: | WB, Flow, CyTOF-ready |
Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
| Chemical Name: | 2-Methyl-6-(phenylethynyl)pyridine hydrochloride |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #464823 |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #ST51-00 |
| Applications: | IHC, WB, Flow, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: mGluR5 Antibody (ST51-00) [NBP3-11866]](https://resources.rndsystems.com/images/products/mGluR5-Antibody-ST51-00-Immunocytochemistry-Immunofluorescence-NBP3-11866-img0005.jpg "Immunocytochemistry/ Immunofluorescence: mGluR5 Antibody (ST51-00) [NBP3-11866]")
Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
| Chemical Name: | (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt |
| Purity: | ≥99% |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1A11D10 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: mGluR5 Antibody (1A11D10)BSA Free [NBP2-61828]](https://resources.rndsystems.com/images/products/mGluR5-Antibody-1A11D10-Western-Blot-NBP2-61828-img0005.jpg "Western Blot: mGluR5 Antibody (1A11D10)BSA Free [NBP2-61828]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | IHC, WB |
AMPA agonist; also group I mGlu agonist
| Chemical Name: | (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid |
| Purity: | ≥99% |
mGlu5 selective agonist
| Chemical Name: | (RS)-2-Chloro-5-hydroxyphenylglycine |
| Purity: | ≥99% |
Potent and selective mGlu5 negative allosteric modulator (NAM)
| Chemical Name: | N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea |
| Purity: | ≥98% |
Group I mGlu antagonist
| Chemical Name: | N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide |
| Purity: | ≥98% |
| Reactivity: | Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: mGluR5 Antibody [NBP3-13190]](https://resources.rndsystems.com/images/products/mGluR5-Antibody-Immunocytochemistry-Immunofluorescence-NBP3-13190-img0002.jpg "Immunocytochemistry/ Immunofluorescence: mGluR5 Antibody [NBP3-13190]")
Potent group I mGlu antagonist
| Chemical Name: | N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide |
| Purity: | ≥98% |
Potent and selective mGlu5 antagonist
| Chemical Name: | 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride |
| Purity: | ≥98% |
| Reactivity: | Human |
| Source: | NS0 |
| Accession #: | P41594 |
| Reactivity: | Human |
| Reactivity: | Human, Mouse, Rat, Porcine, Bat, +8 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: mGluR5 Antibody - BSA Free [NBP1-02331]](https://resources.rndsystems.com/images/products/mGluR5-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NBP1-02331-img0002.jpg "Immunohistochemistry-Paraffin: mGluR5 Antibody - BSA Free [NBP1-02331]")
Positive allosteric modulator of mGlu5 receptors
| Chemical Name: | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide |
| Purity: | ≥98% |
GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors
| Alternate Names: | Topamax |
| Chemical Name: | 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate |
| Purity: | ≥98% |
Active metabolite of oxcarbazepine (Cat. No. 3864)
| Alternate Names: | GP 47779 |
| Chemical Name: | 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide |
| Purity: | ≥98% |
Positive allosteric modulator of mGlu5 receptors
| Chemical Name: | N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride |
| Purity: | ≥98% |
Positive allosteric modulator of group I mGlu receptors
| Chemical Name: | (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester |
| Purity: | ≥98% |
Negative allosteric modulator of mGlu5 receptors
| Alternate Names: | Raseglurant |
| Chemical Name: | 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride |
| Purity: | ≥98% |
Potent and selective positive allosteric modulator of mGlu5 receptors
| Chemical Name: | N-(1-Methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide |
| Purity: | ≥98% |
Potent and selective mGlu5 antagonist; brain penetrant
| Chemical Name: | 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% |
