Human/Hamster ACE-2 Antibody

Catalog # Availability Size / Price Qty
MAB933
MAB933-SP

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Detection of Human ACE‑2 by Western Blot.
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Product Details
Citations (53)
FAQs
Supplemental Products
Reviews (4)

Human/Hamster ACE-2 Antibody Summary

Species Reactivity
Human, Hamster
Specificity
Detects human ACE-2 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) ACE-1 or rhNeprilysin is observed.
Source
Monoclonal Mouse IgG2A Clone # 171606
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ACE-2
Gln18-Ser740 (predicted)
Accession # Q9BYF1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
2 µg/mL
See below
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human ACE-2 antibody by Western Blot. View Larger

Detection of Human ACE‑2 by Western Blot. Western blot shows lysates of NS0 mouse myeloma cell line and human kidney tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human ACE-2 Monoclonal Antibody (Catalog # MAB933) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for ACE-2 at approximately 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry ACE-2 antibody in Human Kidney by Immunohistochemistry (IHC-P). View Larger

ACE‑2 in Human Kidney. ACE-2 was detected in immersion fixed paraffin-embedded sections of human kidney using Mouse Anti-Human ACE-2 Monoclonal Antibody (Catalog # MAB933) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cell surface of epithelial cells in convoluted tubules. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry ACE‑2 antibody in Hamster Lung by Immunohistochemistry (IHC-P). View Larger

ACE‑2 in Hamster Lung. ACE‑2 was detected in immersion fixed paraffin-embedded sections of hamster lung using Mouse Anti-Human ACE‑2 Monoclonal Antibody (Catalog # MAB933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to respiratory bronchioles. Staining was performed our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry Detection of Human ACE-2 by Immunohistochemistry View Larger

Detection of Human ACE-2 by Immunohistochemistry In microvasculature, ACE2 is putatively expressed in pericytes. (A) Representative image of human pancreatic Formalin-Fixed Paraffin Embedded (FFPE) section stained for ACE2 in case #301118. In panel-a, a representative image of a pancreatic section showing two adjacent lobules (blue and red dotted lines) with different staining for ACE2 in endothelial cells/pericytes. A specific segmentation of the two lobules with high (blue) (zoom-in, panel-b) and low or null expression of ACE2 (red) (zoom-in, panel-c) is shown, suggesting lobularity of ACE2 expression in exocrine endothelial cells/pericytes of human pancreas. Scale bar in panel-a: 100 µm. Scale bar in panels-b and -c: 30 µm. (B) Double immunofluorescence staining of ACE2 (green) and CD31 (red) in FFPE pancreas sections from Body01A of Case #110118 (panels-a to -d) and of Body01B of Case #141117 (panels-e to -i). Digital zoom-in overlay images are shown in panels-d, -h and -i. Scale bar in panels-d and -g: 100 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33281748), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human ACE-2 by Immunohistochemistry View Larger

Detection of Human ACE-2 by Immunohistochemistry ACE2 staining pattern in human pancreas. Immunohistochemistry for ACE2 in human pancreatic tissue sections (case #110118) using R&D MAB933 antibody. ACE2 is markedly expressed in microvasculature associated cells (A, B) in some rare ductal cells (C, D) and in a subset of endocrine cells within pancreatic islets (E, F). Scale bars in (A, C, E) 150 µm. Scale bars in (B, D, F) 70 µm. Zoom-in images are reported in (B, D, F). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33281748), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human ACE-2 by Immunohistochemistry View Larger

Detection of Human ACE-2 by Immunohistochemistry In microvasculature, ACE2 is putatively expressed in pericytes. (A) Representative image of human pancreatic Formalin-Fixed Paraffin Embedded (FFPE) section stained for ACE2 in case #301118. In panel-a, a representative image of a pancreatic section showing two adjacent lobules (blue and red dotted lines) with different staining for ACE2 in endothelial cells/pericytes. A specific segmentation of the two lobules with high (blue) (zoom-in, panel-b) and low or null expression of ACE2 (red) (zoom-in, panel-c) is shown, suggesting lobularity of ACE2 expression in exocrine endothelial cells/pericytes of human pancreas. Scale bar in panel-a: 100 µm. Scale bar in panels-b and -c: 30 µm. (B) Double immunofluorescence staining of ACE2 (green) and CD31 (red) in FFPE pancreas sections from Body01A of Case #110118 (panels-a to -d) and of Body01B of Case #141117 (panels-e to -i). Digital zoom-in overlay images are shown in panels-d, -h and -i. Scale bar in panels-d and -g: 100 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33281748), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human ACE-2 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human ACE-2 by Immunocytochemistry/Immunofluorescence In microvasculature, ACE2 is putatively expressed in pericytes. (A) Representative image of human pancreatic Formalin-Fixed Paraffin Embedded (FFPE) section stained for ACE2 in case #301118. In panel-a, a representative image of a pancreatic section showing two adjacent lobules (blue and red dotted lines) with different staining for ACE2 in endothelial cells/pericytes. A specific segmentation of the two lobules with high (blue) (zoom-in, panel-b) and low or null expression of ACE2 (red) (zoom-in, panel-c) is shown, suggesting lobularity of ACE2 expression in exocrine endothelial cells/pericytes of human pancreas. Scale bar in panel-a: 100 µm. Scale bar in panels-b and -c: 30 µm. (B) Double immunofluorescence staining of ACE2 (green) and CD31 (red) in FFPE pancreas sections from Body01A of Case #110118 (panels-a to -d) and of Body01B of Case #141117 (panels-e to -i). Digital zoom-in overlay images are shown in panels-d, -h and -i. Scale bar in panels-d and -g: 100 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33281748), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

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Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ACE-2

Angiogensin I Converting Enzyme-2 (ACE-2), also called ACEH (ACE homolog), is a type I transmembrane zinc protease that cleaves angiotensins I and II to produce vasodilatory and anti-proliferative peptides. The balance between ACE-1 and ACE-2 activity is critical for maintaining cardiovascular, renal, and pulmonary function (1). ACE-2 also functions as the cellular uptake receptor for the SARS coronoavirus. Within the extracellular domain, human ACE-2 shares 83% aa sequence identity with mouse and rat ACE-2. Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 mRNA is found at high levels in testis, kidney and heart and at moderate levels in colon, small intestine and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity (2). Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo (3). ACE-2 isoforms of 75 kDa and 120 kDa are differentially expressed between lung and kidney, respectively, and a shed soluble form is generated by TACE/ADAM17 mediated cleavage.

References
  1. Tipnis, S.R. et al. (2000) J. Biol. Chem. 275:33238.
  2. Crackower,  M.A. et al. (2002) Nature 417:822.
  3. Huang, L. et al. (2003) J. Biol. Chem. 278:15532.
Long Name
Angiotensin I Converting Enzyme 2
Entrez Gene IDs
59272 (Human); 70008 (Mouse); 302668 (Rat); 100144303 (Porcine); 480847 (Canine); 418623 (Chicken); 102130864 (Cynomolgus Monkey); 554349 (Feline); 101673097 (Ferret); 101823817 (Hamster); 108390919 (Malayan Pangolin)
Alternate Names
ACE2; ACE-2; ACEH; ACEHangiotensin I converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; DKFZp434A014; EC 3.4.17; EC 3.4.17.23; Metalloprotease MPROT15

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Citations for Human/Hamster ACE-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

53 Citations: Showing 1 - 10
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  1. SARS-CoV-2 virus associated angiotensin converting enzyme 2 expression modulation in colorectal cancer: Insights from mRNA and protein analysis COVID-19 associated (ACE2) expression in colorectal cancer
    Authors: Alotaibi, MA;Al-Hazani, TMI;Alwaili, MA;Jalal, AS;Alshaya, DS;Safhi, FA;Alamoudi, MO;Alarifi, S;Saeed Al-Qahtani, W;
    Microbial pathogenesis
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. Human Taste Cells Express ACE2: a Portal for SARS-CoV-2 Infection
    Authors: Máire E Doyle, Ashley Appleton, Qing-Rong Liu, Qin Yao, Caio Henrique Mazucanti, Josephine M Egan
    bioRxiv
  3. Molecular Mechanisms of Endothelialitis in SARS-CoV-2 Infection: Evidence for VE-Cadherin Cleavage by ACE2
    Authors: Bouillet, L;Deroux, A;Benmarce, M;Guérin, C;Bouvet, L;Garnier, O;Martin, DK;Vilgrain, I;
    International journal of molecular sciences
    Species: Human
    Sample Types: Serum
    Applications: Western Blot
  4. Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells
    Authors: Uppal S, Postnikova O, Villasmil R et al.
    International journal of molecular sciences
  5. Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus
    Authors: José Manuel Hernandez-Lopez, Cristina Hernandez-Medina, Cristina Medina-Corvalan, Mónica Rodenas, Almagro Francisca, Claudia Perez-Garcia et al.
    Cellular and Molecular Life Sciences
  6. Rapid Generation of Pulmonary Organoids from Induced Pluripotent Stem Cells by Co-Culturing Endodermal and Mesodermal Progenitors for Pulmonary Disease Modelling
    Authors: Mitchell, A;Yu, C;Zhao, X;Pearmain, L;Shah, R;Hanley, KP;Felton, T;Wang, T;
    Biomedicines
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  7. Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic
    Authors: Ogawa, K;Khan, KN;Koshiba, A;Fujishita, A;Horiguchi, G;Teramukai, S;Itoh, K;Guo, SW;Mori, T;
    BMC women's health
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  8. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity
    Authors: Zintis Inde, Clarence Yapp, Gaurav N. Joshi, Johan Spetz, Cameron Fraser, Brian Deskin et al.
    bioRxiv
  9. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2
    Authors: Donglan Liu, Chunke Chen, Dingbin Chen, Airu Zhu, Fang Li, Zhen Zhuang et al.
    Proceedings of the National Academy of Sciences
  10. Angiotensin I-Converting Enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors
    Authors: Fignani, D;Pedace, E;Licata, G;Grieco, G;Aiello, E;Luca, C;Marselli, L;Marchetti, P;Sebastiani, G;Dotta, F;
    medRxiv
    Species:  Human
    Sample Types: Whole Tissue
    Applications: IHC/IF
  11. Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation
    Authors: GU Jeong, HJ Kwon, WH Ng, X Liu, HW Moon, GY Yoon, HJ Shin, IC Lee, ZL Ling, AG Spiteri, NJC King, A Taylor, JS Chae, C Kim, DG Ahn, KD Kim, YB Ryu, SJ Kim, S Mahalingam, YC Kwon
    Nature Communications, 2022-12-12;13(1):7675.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: ICC/IF
  12. Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
    Authors: Máire E. Doyle, Ashley Appleton, Qing-Rong Liu, Qin Yao, Caio H. Mazucanti, Josephine M. Egan
    The American Journal of Pathology
  13. Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease
    Authors: Jaspreet Osan, Sattya N. Talukdar, Friederike Feldmann, Beth Ann DeMontigny, Kailey Jerome, Kristina L. Bailey et al.
    Microbiology Spectrum
  14. Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy
    Authors: Christophe Deben, Maxim Le Compte, Vasiliki Siozopoulou, Hilde Lambrechts, Christophe Hermans, Ho Wa Lau et al.
    Cancers (Basel)
  15. GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility
    Authors: Margalida Torrens-Mas, Catalina M. Perelló-Reus, Neus Trias-Ferrer, Lesly Ibargüen-González, Catalina Crespí, Aina Maria Galmes-Panades et al.
    Frontiers in Cellular and Infection Microbiology
  16. Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways
    Authors: Daniel Richard, Pushpanathan Muthuirulan, Jennifer Aguiar, Andrew C. Doxey, Arinjay Banerjee, Karen Mossman et al.
    iScience
  17. Atypical Unilateral SARS-CoV-2 Pneumonia in a Single Lung Re-Transplanted Patient: A Case Report
    Authors: M Furstenber, F Gallais, S Freudenber, R Kessler, MP Chenard, B Renaud-Pic
    Transplantation Proceedings, 2022-05-30;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  18. Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19
    Authors: Ikram Omar Osman, Clémence Garrec, Gabriel Augusto Pires de Souza, Ana Zarubica, Djamal Brahim Belhaouari, Jean-Pierre Baudoin et al.
    Frontiers in Cellular and Infection Microbiology
  19. COVID‐19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS‐CoV‐2 infection
    Authors: M A Beesley, J R Davidson, F Panariello, S Shibuya, D Scaglioni, B C Jones et al.
    BJOG: An International Journal of Obstetrics & Gynaecology
  20. OM-85 Broncho-Vaxom�, a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial Cells
    Authors: L Fang, L Zhou, M Tamm, M Roth
    Biomedicines, 2021-10-26;9(11):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  21. Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues
    Authors: Gottfried Martin, Julian Wolf, Thabo Lapp, Hansjürgen T. Agostini, Günther Schlunck, Claudia Auw-Hädrich et al.
    Scientific Reports
  22. ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1
    Authors: Mingming Han, Deepesh Pandey
    American Journal of Respiratory Cell and Molecular Biology
  23. Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors
    Authors: MJ Munro, L Peng, SK Wickremese, ST Tan
    PLoS ONE, 2021-08-24;16(8):e0256280.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  24. ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes
    Authors: EJ Sherman, BT Emmer
    Scientific Reports, 2021-08-05;11(1):15900.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  25. Angiotensin II Receptor Blockers (ARBs Antihypertensive Agents) Increase Replication of SARS-CoV-2 in Vero E6 Cells
    Authors: Gabriel Augusto Pires de Souza, Ikram Omar Osman, Marion Le Bideau, Jean-Pierre Baudoin, Rita Jaafar, Christian Devaux et al.
    Frontiers in Cellular and Infection Microbiology
  26. Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D
    Authors: Jian Zheng, David Meyerholz, Lok-Yin Roy Wong, Michael Gelb, Makoto Murakami, Stanley Perlman
    Journal of Clinical Investigation
  27. Expression of Components of the Renin-Angiotensin System by Cancer Stem Cells in Renal Clear Cell Carcinoma
    Authors: S Siljee, B Milne, HD Brasch, N Bockett, J Patel, PF Davis, A Kennedy-Sm, T Itinteang, ST Tan
    Biomolecules, 2021-04-07;11(4):.
    Species: Human
    Sample Types: Tissue Lysates, Whole Tissue
    Applications: IHC-P, Western Blot
  28. Role of Cigarette Smoke on Angiotensin-Converting Enzyme-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model
    Authors: Massimo Caruso, Alfio Distefano, Rosalia Emma, Michelino Di Rosa, Giuseppe Carota, Sonja Rust et al.
    Frontiers in Pharmacology
  29. SARS‐CoV‐2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice
    Authors: Yuanwu Ma, Dan Lu, Linlin Bao, Yajin Qu, Jiangning Liu, Xiaolong Qi et al.
    Animal Models and Experimental Medicine
  30. Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases
    Authors: Rafael S. Grajewski, Alexander C. Rokohl, Martina Becker, Friedrich Paulsen, Ludwig M. Heindl
    Annals of Anatomy - Anatomischer Anzeiger
  31. Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System
    Authors: S Siljee, O Buchanan, HD Brasch, N Bockett, J Patel, E Paterson, GL Purdie, PF Davis, T Itinteang, ST Tan
    Cells, 2021-01-27;10(2):.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  32. Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol
    Authors: Jose Manuel Condor Capcha, Guerline Lambert, Derek M. Dykxhoorn, Alessandro G. Salerno, Joshua M. Hare, Michael A. Whitt et al.
    Frontiers in Cardiovascular Medicine
  33. A missing link between SARS‐CoV‐2 and the eye?: ACE2 expression on the ocular surface
    Authors: Rafael S. Grajewski, Alexander C. Rokohl, Martina Becker, Felix Dewald, Clara Lehmann, Gerd Fätkenheuer et al.
    Journal of Medical Virology
  34. Comparison of Four SARS-CoV-2 Neutralization Assays
    Authors: L Riepler, A Rössler, A Falch, A Volland, W Borena, D von Laer, J Kimpel
    Vaccines, 2020-12-28;9(1):.
    Species: Human
    Sample Types: Cell Lysates
  35. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
    Authors: Ruochen Zang, James Brett Case, Eylan Yutuc, Xiucui Ma, Sheng Shen, Maria Florencia Gomez Castro et al.
    Proceedings of the National Academy of Sciences
  36. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19
    Authors: Kusmartseva I, Wu W, Syed F et al.
    Cell Metabolism
  37. SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic beta -Cells and in the Human Pancreas Microvasculature
    Authors: Daniela Fignani, Giada Licata, Noemi Brusco, Laura Nigi, Giuseppina E. Grieco, Lorella Marselli et al.
    Front Endocrinol (Lausanne)
  38. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
    Authors: IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schürch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, H Chen, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, A Tzankov, MS Matter, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson
    Nat Commun, 2020-10-28;11(1):5453.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  39. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction
    Authors: H Katsura, V Sontake, A Tata, Y Kobayashi, CE Edwards, BE Heaton, A Konkimalla, T Asakura, Y Mikami, EJ Fritch, PJ Lee, NS Heaton, RC Boucher, SH Randell, RS Baric, PR Tata
    Cell Stem Cell, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Expression of the COVID‐19 receptor ACE2 in the human conjunctiva
    Authors: Clemens Lange, Julian Wolf, Claudia Auw‐Haedrich, Anja Schlecht, Stefaniya Boneva, Thabo Lapp et al.
    Journal of Medical Virology
  41. Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
    Authors: ME Ortiz, A Thurman, AA Pezzulo, MR Leidinger, JA Klesney-Ta, PH Karp, P Tan, C Wohlford-L, PB McCray, DK Meyerholz
    EBioMedicine, 2020-09-21;60(0):102976.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  42. Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
    Authors: Jennifer A. Aguiar, Benjamin J-M. Tremblay, Michael J. Mansfield, Owen Woody, Briallen Lobb, Arinjay Banerjee et al.
    European Respiratory Journal
  43. ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection
    Authors: G Descamps, L Verset, A Trelcat, C Hopkins, JR Lechien, F Journe, S Saussez
    Biology (Basel), 2020-08-18;9(8):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  44. Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
    Authors: ME Ortiz Beza, A Thurman, AA Pezzulo, MR Leidinger, JA Klesney-Ta, PH Karp, P Tan, C Wohlford-L, PB McCray, DK Meyerholz
    bioRxiv, 2020-08-13;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  45. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
    Authors: Jing Sun, Zhen Zhuang, Jian Zheng, Kun Li, Roy Lok-Yin Wong, Donglan Liu et al.
    Cell
  46. The protein expression profile of ACE2 in human tissues
    Authors: Feria Hikmet, Loren Méar, Åsa Edvinsson, Patrick Micke, Mathias Uhlén, Cecilia Lindskog
    Molecular Systems Biology
  47. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
    Authors: IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schurch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson
    medRxiv, 2020-05-12;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  48. Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma
    Authors: M Yamaguchi, S Hirai, T Sumi, Y Tanaka, M Tada, Y Nishii, T Hasegawa, H Uchida, G Yamada, A Watanabe, H Takahashi, Y Sakuma
    Biochem. Biophys. Res. Commun., 2017-04-20;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  49. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
    Authors: Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pohlmann S
    J Virol, 2013-11-13;88(2):1293-307.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Functional Assay, Western Blot
  50. Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme.
    Authors: Iwata M, Silva Enciso JE, Greenberg BH
    Am. J. Physiol., Cell Physiol., 2009-09-16;297(5):C1318-29.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  51. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.
    Authors: Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S
    Am. J. Physiol. Heart Circ. Physiol., 2008-07-25;295(4):H1377-84.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  52. JNK and PI3k/Akt signaling pathways are required for establishing persistent SARS-CoV infection in Vero E6 cells.
    Authors: Mizutani T, Fukushi S, Saijo M, Kurane I, Morikawa S
    Biochim. Biophys. Acta, 2005-06-30;1741(1):4-10.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  53. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
    Authors: Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pohlmann S
    Biochem. Biophys. Res. Commun., 2004-07-09;319(4):1216-21.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

FAQs

  1. Is Catalog # MAB933 kappa or lambda light chain?

    • MAB933 is kappa light chain.

  2. Does Human/Hamster ACE-2 Antibody, Catalog# MAB933, detect mouse ACE2?

    • We have not evaluated cross-reactivity of this antibody to mouse ACE-2. Human ACE-2 shares 83% amino acid sequence identity with mouse ACE-2. We have one citation on our webpage where researcher reports using MAB933 to detect mouse ACE-2. 

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Reviews for Human/Hamster ACE-2 Antibody

Average Rating: 4.5 (Based on 4 Reviews)

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Human/Hamster ACE-2 Antibody
By Anonymous on 11/26/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Human cell line Species: Human

Human/Hamster ACE-2 Antibody
By Anonymous on 10/19/2021
Application: IHC Sample Tested: Lung tissue Species: Human

Human/Hamster ACE-2 Antibody
By Anonymous on 08/04/2021
Application: IHC Sample Tested: Small intestine Species: Human

Human/Hamster ACE-2 Antibody
By deng guo on 09/28/2020
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Mouse IMCD3 cells Species: Human ACE2

IMCD3 cells were transiently transfected with human ACE2. 48 hrs post transfection, the cells were fixed, then stain with the ACE2 antibody (1:250 dilution).