Human Mer Antibody
Human Mer Antibody Summary
Met1-Ala499
Accession # AAB60430
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Applications
Human Mer Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mer in HepG2 Human Cell Line by Flow Cytometry. HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human Mer Monoclonal Antibody (Catalog # MAB8912, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).
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Detection of Mer in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human Mer Monoclonal Antibody (Catalog # MAB8912, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).
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Mer Specificity is Shown by Flow Cytometry in Knockout Cell Line. Mer knockout HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human Mer Monoclonal Antibody (Catalog # MAB8912, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram) followed by anti-Mouse IgG PE-conjugated secondary antibody (Catalog # F0102B). No staining in the Mer knockout HepG2 cell line was observed. View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Mer
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Product Datasheets
Citations for Human Mer Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
8
Citations: Showing 1 - 8
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Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia
Authors: RJ Summers, J Jain, E Vasileiadi, B Smith, ML Chimenti, TY Yeung, J Kelvin, X Wang, SV Frye, HS Earp, JW Tyner, EC Dreaden, D DeRyckere, DK Graham
Cancers, 2022;14(24):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Small Molecule Inhibitors of MERTK and FLT3 Induce Cell Cycle Arrest in Human CD8+ T Cells
Authors: RM Powell, MJW Peeters, A Rahbech, P Aehnlich, T Seremet, P Thor Strat
Vaccines, 2021;9(11):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
UNC5293, a potent, orally available and highly MERTK-selective inhibitor
Authors: H Zheng, J Zhao, B Li, W Zhang, MA Stashko, KA Minson, MG Huey, Y Zhou, HS Earp, D Kireev, DK Graham, D DeRyckere, SV Frye, X Wang
European Journal of Medicinal Chemistry, 2021;220(0):113534.
Species: Human
Sample Types: Cell Lysates
Applications: IP -
CD14(+)CD15(-)HLA-DR(-) myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure
Authors: C Bernsmeier, E Triantafyl, R Brenig, FJ Lebosse, A Singanayag, VC Patel, OT Pop, W Khamri, R Nathwani, R Tidswell, CJ Weston, DH Adams, MR Thursz, JA Wendon, CG Antoniades
Gut, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles
Authors: KE Happonen, S Tran, M Mörgelin, R Prince, S Calzavarin, A Angelillo-, B Dahlbäck
J. Biol. Chem., 2016;291(20):10586-601.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
J. Exp. Med., 2012;209(11):2033-47.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques.
Authors: Hurtado B, Munoz X, Recarte-Pelz P, Garcia N, Luque A, Krupinski J, Sala N, Garcia de Frutos P
Thromb. Haemost., 2011;105(5):873-82.
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot -
GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche.
Authors: Shiozawa Y, Pedersen EA, Taichman RS
Exp. Hematol., 2010;38(2):132-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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Average Rating: 4.5 (Based on 2 Reviews)
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