Rat TIM-1/KIM-1/HAVCR Antibody
Rat TIM-1/KIM-1/HAVCR Antibody Summary
Ser18-Val238
Accession # O54947
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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TIM‑1/KIM‑1/HAVCR in Rat Kidney. TIM-1/KIM-1/HAVCR was detected in perfusion fixed frozen sections of rat kidney using 15 µg/mL Rat TIM-1/KIM-1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3689) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TIM-1/KIM-1/HAVCR
KIM-1 (Kidney-injury molecule-1; also TIM-1 and HAVCR) is a 50-80 kDa, variably glycosylated, type I transmembrane glycoprotein that is a member of the TIM family of immunoglobulin superfamily molecules. This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. In mouse, there are eight known TIM/KIM genes (# 1-8) vs. only three genes in human (# 1, 3, 4). It is unknown if the rat genome exactly parallels that of mouse. Rat KIM-1 is synthesized as a 307 amino acid (aa) precursor that contains a 21 aa signal sequence, a 214 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 51 aa cytoplasmic domain. The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple Thr-Ser-Pro motifs. The mucin region may undergo extensive O-linked glycosylation. The mouse KIM-1 gene is highly polymorphic and this may be reflected in rat. In human, TIM-1 is known to circulate as a soluble form. It undergoes constitutive cleavage by an undefined MMP, releasing an 85 kDa soluble molecule. A similar process has now been described in rat. The ECD of rat KIM-1 is 50% and 81% aa identical to human and mouse KIM-1 ECD, respectively. The only two reported ligands for KIM-1 are TIM-4 and the hepatitis A virus. However, others are believed to exist, and based on the ligand for TIM-3, one might be an S-type lectin. KIM-1 is found on CD4+ T cells and proximal renal tubular cells. KIM-1 ligation induces T cell proliferation and promotes cytokine production. In particular, it induces IL-4 production, and requires the KIM-1 cytoplasmic tyrosine phosphorylation motif. Alternatively, KIM-1 activation of TIM-4 induces cell cycle arrest.
Product Datasheets
Product Specific Notices
This product is covered by one or more of the following US Patents 7,300,652; 7,041,290; 6,664,385 and other US and foreign patents pending or issued.Citations for Rat TIM-1/KIM-1/HAVCR Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
Authors: MM Rinschen, O Palygin, A El-Meanawy, X Domingo-Al, A Palermo, LV Dissanayak, D Golosova, MA Schafroth, C Guijas, F Demir, J Jaegers, ML Gliozzi, J Xue, M Hoehne, T Benzing, BP Kok, E Saez, M Bleich, N Himmerkus, OA Weisz, BF Cravatt, M Krüger, HP Benton, G Siuzdak, A Staruschen
Nature Communications, 2022;13(1):4099.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Nephrotoxicity evaluation and proteomic analysis in kidneys of rats exposed to thioacetamide
Authors: JY Lim, WW Jung, W Kim, KS Moon, D Sul
Scientific Reports, 2022;12(1):6837.
Species: Rat
Sample Types: Tissue Lysates
Applications: Western Blot -
Using Green Biosynthesized Lycopene-Coated Selenium Nanoparticles to Rescue Renal Damage in Glycerol-Induced Acute Kidney Injury in Rats
Authors: A Al-Brakati, KF Alsharif, KJ Alzahrani, S Kabrah, O Al-Amer, AA Oyouni, OA Habotta, MS Lokman, AA Bauomy, RB Kassab, AE Abdel Mone
International Journal of Nanomedicine, 2021;16(0):4335-4349.
Species: Rat
Sample Types: Plasma
Applications: ELISA Capture -
Empagliflozin attenuates acute kidney injury after myocardial infarction in diabetic rats
Authors: A Kuno, Y Kimura, M Mizuno, H Oshima, T Sato, N Moniwa, M Tanaka, T Yano, M Tanno, T Miki, T Miura
Sci Rep, 2020;10(1):7238.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes
Authors: M Kitada, Y Ogura, I Monno, J Xu, D Koya
Aging (Albany NY), 2020;12(5):4489-4505.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Distinct inactivated bacterial-based immune modulators vary in their therapeutic efficacies for treating disease based on the organ site of pathology
Authors: S Kalyan, M Bazett, HP Sham, M Bosiljcic, B Luk, S Dhanji, AM Costa, SWY Wong, MG Netea, DW Mullins, H Gunn
Sci Rep, 2020;10(1):5901.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats
Authors: Y Kimura, A Kuno, M Tanno, T Sato, K Ohno, S Shibata, K Nakata, H Sugawara, K Abe, Y Igaki, T Yano, T Miki, T Miura
J Diabetes Investig, 2019;0(0):.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats
Authors: K Toyoda, Y Suzuki, K Muta, T Masuyama, K Kakimoto, A Kobayashi, T Shoda, S Sugai
J Toxicol Sci, 2018;43(1):45-58.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits
Authors: W Ding, K Yousefi, S Goncalves, BJ Goldstein, AL Sabater, A Kloosterbo, P Ritter, G Lambert, AJ Mendez, LA Shehadeh
JCI Insight, 2018;3(6):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury
Authors: YX He, TT Diao, SM Song, CC Wang, Y Wang, CL Zhou, YB Bai, SS Yu, X Mi, XY Yang, QJ Wei, B Li
Sci Rep, 2018;8(1):10555.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats
Authors: PC Vogelaar, M Roorda, EL de Vrij, MC Houwertjes, M Goris, H Bouma, AC van der Gr, G Krenning, RH Henning
Nephrol. Dial. Transplant., 2018;0(0):.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome
Authors: KH Chen, CH Chen, CG Wallace, YT Chen, CC Yang, PH Sung, HJ Chiang, YL Chen, S Chua, HK Yip, JT Cheng
Am J Transl Res, 2017;9(2):214-229.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Combination therapy of exendin-4 and allogenic adipose-derived mesenchymal stem cell preserved renal function in a chronic kidney disease and sepsis syndrome setting in rats
Authors: CH Chen, BC Cheng, KH Chen, PL Shao, PH Sung, HJ Chiang, CC Yang, KC Lin, CK Sun, JJ Sheu, HW Chang, MS Lee, HK Yip
Oncotarget, 2017;8(59):100002-100020.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells
Authors: X Chen, A Cobbs, J George, A Chima, F Tuyishime, X Zhao
Int J Mol Sci, 2017;18(8):.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats.
Authors: Nozako M, Koyama T, Nagano C, Sato M, Matsumoto S, Mitani K, Yasufuku R, Kohashi M, Yoshikawa T
PLoS ONE, 2015;10(11):e0143979.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Altered expression profile of renal alpha(1D)-adrenergic receptor in diabetes and its modulation by PPAR agonists.
Authors: Zhao X, Zhang Y, Leander M, Li L, Wang G, Emmett N
J Diabetes Res, 2014;2014(0):725634.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
PLoS ONE, 2013;8(12):e83687.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Urinary levels of regenerating islet-derived protein III beta and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats.
Authors: Ferreira L, Quiros Y, Sancho-Martinez SM, Garcia-Sanchez O, Raposo C, Lopez-Novoa JM, Gonzalez-Buitrago JM, Lopez-Hernandez FJ
Kidney Int., 2011;79(5):518-28.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
Sub-nephrotoxic doses of gentamicin predispose animals to developing acute kidney injury and to excrete ganglioside M2 activator protein.
Authors: Quiros Y, Ferreira L, Sancho-Martinez SM, Gonzalez-Buitrago JM, Lopez-Novoa JM, Lopez-Hernandez FJ
Kidney Int., 2010;78(10):1006-15.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot
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